prikaz prve stranice dokumenta E-cadherin and beta-catenin expression patterns in malignant melanoma assessed by image analysis
  Download
PDF 4.02 MB
Scientific paper - Original scientific paper
E-cadherin and beta-catenin expression patterns in malignant melanoma assessed by image analysis
Journal of Cutaneous Pathology, 34 (2007), 3; 239-246. https://doi.org/10.1111/j.1600-0560.2006.00601.x
Pećina-Šlaus, Nives; Žigmund, Martina; Kušec, Vesna; Nikuševa Martić, Tamara; Čačić, Mirjana; Šlaus, Mario

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Pećina Šlaus, N., Žigmund, M., Kušec, V., Nikuševa Martić, T., Čačić, M. & Šlaus, M. (2007). E-cadherin and beta-catenin expression patterns in malignant melanoma assessed by image analysis. Journal of Cutaneous Pathology, 34. (3), 239-246. doi: 10.1111/j.1600-0560.2006.00601.x

Pećina Šlaus, Nives, et al. "E-cadherin and beta-catenin expression patterns in malignant melanoma assessed by image analysis." Journal of Cutaneous Pathology, vol. 34, no. 3, 2007, pp. 239-246. https://doi.org/10.1111/j.1600-0560.2006.00601.x

Pećina Šlaus, Nives, Martina Žigmund, Vesna Kušec, Tamara Nikuševa Martić, Mirjana Čačić and Mario Šlaus. "E-cadherin and beta-catenin expression patterns in malignant melanoma assessed by image analysis." Journal of Cutaneous Pathology 34, no. 3 (2007): 239-246. https://doi.org/10.1111/j.1600-0560.2006.00601.x

Pećina Šlaus, N., et al. (2007) 'E-cadherin and beta-catenin expression patterns in malignant melanoma assessed by image analysis', Journal of Cutaneous Pathology, 34(3), pp. 239-246. doi: 10.1111/j.1600-0560.2006.00601.x

Pećina Šlaus N, Žigmund M, Kušec V, Nikuševa Martić T, Čačić M, Šlaus M. E-cadherin and beta-catenin expression patterns in malignant melanoma assessed by image analysis. Journal of Cutaneous Pathology [Internet]. 2007 March [cited 2024 November 22];34(3):239-246. doi: 10.1111/j.1600-0560.2006.00601.x

N. Pećina Šlaus, M. Žigmund, V. Kušec, T. Nikuševa Martić, M. Čačić and M. Šlaus, "E-cadherin and beta-catenin expression patterns in malignant melanoma assessed by image analysis", Journal of Cutaneous Pathology, vol. 34, no. 3, pp. 239-246, March 2007. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:364608. [Accessed: 22 November 2024]

Metadata
Title (english)E-cadherin and beta-catenin expression patterns in malignant melanoma assessed by image analysis
AuthorNives Pećina-Šlaus
AuthorMartina Žigmund
AuthorVesna Kušec
AuthorTamara Nikuševa Martić
AuthorMirjana Čačić
AuthorMario Šlaus
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
BACKGROUND: We investigated the expression of E-cadherin and beta-catenin in melanoma. Both proteins are components of adherens junctions but also play signalling roles in the wnt signal transduction pathway. ----- MATERIALS AND METHODS: Seventy malignant melanomas were analysed by immunohistochemistry and evaluated by image analysis as staining density, i.e. light permeability (LP). ----- RESULTS: Comparison of mean values of relative LP for E-cadherin and beta-catenin in tumor tissue shows that levels of E-cadherin protein are significantly lower (259.67-116.23; t=22.7; p=0.000). The comparison of mean values of the relative LP of E-cadherin in melanoma to the LP in the adjacent normal skin also shows that the expression of E-cadherin in tumor is significantly lower (256.06-169.87; t=11.55, p=0.000). beta-catenin was observed in the cytoplasm in 30.6% of patients, in 24.2% in the cell membrane, in 21% in both the cytoplasm and membrane, in 1.6% in the membrane and nucleus and in 4.8% in the cytoplasm and nucleus, whereas in 17.7% of patients beta-catenin could not be observed. Patients with Clark 4 and 5 had significantly less beta-catenin than patients with Clark 2 and 3 (chi2=12.854; p=0.005). ----- CONCLUSIONS: Changes in E-cadherin and beta-catenin levels have important roles in melanoma and could be used as molecular markers of disease progression.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleJournal of Cutaneous Pathology
Numberingvol. 34, no. 3, pp. 239-246
p-ISSN0303-6987
DOIhttps://doi.org/10.1111/j.1600-0560.2006.00601.x
URN:NBNurn:nbn:hr:105:364608
Publication2007-03
Document URLhttps://doi.org/10.1111/j.1600-0560.2006.00601.x
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 10:32:38