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E-cadherin and beta-catenin expression patterns in malignant melanoma assessed by image analysis
Journal of Cutaneous Pathology, 34 (2007), 3; 239-246. https://doi.org/10.1111/j.1600-0560.2006.00601.x
Pećina-Šlaus, Nives; Žigmund, Martina; Kušec, Vesna; Nikuševa Martić, Tamara; Čačić, Mirjana; Šlaus, Mario

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Citirajte ovaj rad

Pećina Šlaus, N., Žigmund, M., Kušec, V., Nikuševa Martić, T., Čačić, M. i Šlaus, M. (2007). E-cadherin and beta-catenin expression patterns in malignant melanoma assessed by image analysis. Journal of Cutaneous Pathology, 34. (3), 239-246. doi: 10.1111/j.1600-0560.2006.00601.x

Pećina Šlaus, Nives, et al. "E-cadherin and beta-catenin expression patterns in malignant melanoma assessed by image analysis." Journal of Cutaneous Pathology, vol. 34, br. 3, 2007, str. 239-246. https://doi.org/10.1111/j.1600-0560.2006.00601.x

Pećina Šlaus, Nives, Martina Žigmund, Vesna Kušec, Tamara Nikuševa Martić, Mirjana Čačić i Mario Šlaus. "E-cadherin and beta-catenin expression patterns in malignant melanoma assessed by image analysis." Journal of Cutaneous Pathology 34, br. 3 (2007): 239-246. https://doi.org/10.1111/j.1600-0560.2006.00601.x

Pećina Šlaus, N., et al. (2007) 'E-cadherin and beta-catenin expression patterns in malignant melanoma assessed by image analysis', Journal of Cutaneous Pathology, 34(3), str. 239-246. doi: 10.1111/j.1600-0560.2006.00601.x

Pećina Šlaus N, Žigmund M, Kušec V, Nikuševa Martić T, Čačić M, Šlaus M. E-cadherin and beta-catenin expression patterns in malignant melanoma assessed by image analysis. Journal of Cutaneous Pathology [Internet]. 03.2007. [pristupljeno 15.05.2024.];34(3):239-246. doi: 10.1111/j.1600-0560.2006.00601.x

N. Pećina Šlaus, M. Žigmund, V. Kušec, T. Nikuševa Martić, M. Čačić i M. Šlaus, "E-cadherin and beta-catenin expression patterns in malignant melanoma assessed by image analysis", Journal of Cutaneous Pathology, vol. 34, br. 3, str. 239-246, Ožujak 2007. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:364608. [Citirano: 15.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:364608
Podaci o radu
Naslov (engleski)E-cadherin and beta-catenin expression patterns in malignant melanoma assessed by image analysis
AutorNives Pećina-Šlaus
AutorMartina Žigmund
AutorVesna Kušec
AutorTamara Nikuševa Martić
AutorMirjana Čačić
AutorMario Šlaus
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
BACKGROUND: We investigated the expression of E-cadherin and beta-catenin in melanoma. Both proteins are components of adherens junctions but also play signalling roles in the wnt signal transduction pathway. ----- MATERIALS AND METHODS: Seventy malignant melanomas were analysed by immunohistochemistry and evaluated by image analysis as staining density, i.e. light permeability (LP). ----- RESULTS: Comparison of mean values of relative LP for E-cadherin and beta-catenin in tumor tissue shows that levels of E-cadherin protein are significantly lower (259.67-116.23; t=22.7; p=0.000). The comparison of mean values of the relative LP of E-cadherin in melanoma to the LP in the adjacent normal skin also shows that the expression of E-cadherin in tumor is significantly lower (256.06-169.87; t=11.55, p=0.000). beta-catenin was observed in the cytoplasm in 30.6% of patients, in 24.2% in the cell membrane, in 21% in both the cytoplasm and membrane, in 1.6% in the membrane and nucleus and in 4.8% in the cytoplasm and nucleus, whereas in 17.7% of patients beta-catenin could not be observed. Patients with Clark 4 and 5 had significantly less beta-catenin than patients with Clark 2 and 3 (chi2=12.854; p=0.005). ----- CONCLUSIONS: Changes in E-cadherin and beta-catenin levels have important roles in melanoma and could be used as molecular markers of disease progression.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaJournal of Cutaneous Pathology
Brojčani podacivol. 34, br. 3, str. 239-246
p-ISSN0303-6987
DOIhttps://doi.org/10.1111/j.1600-0560.2006.00601.x
URN:NBNurn:nbn:hr:105:364608
Datum objave publikacije2007-03
URL dokumentahttps://doi.org/10.1111/j.1600-0560.2006.00601.x
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 10:32:38