prikaz prve stranice dokumenta Changes in T-cell subpopulations during four years of suppression of HIV-1 replication in patients with advanced disease
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Scientific paper - Original scientific paper
Changes in T-cell subpopulations during four years of suppression of HIV-1 replication in patients with advanced disease
FEMS Immunology and Medical Microbiology, 46 (2006), 3; 351-359. https://doi.org/10.1111/j.1574-695X.2005.00034.x
Židovec Lepej, Snježana; Begovac, Josip; Vince, Adriana

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Židovec Lepej, S., Begovac, J. & Vince, A. (2006). Changes in T-cell subpopulations during four years of suppression of HIV-1 replication in patients with advanced disease. FEMS Immunology and Medical Microbiology, 46. (3), 351-359. doi: 10.1111/j.1574-695X.2005.00034.x

Židovec Lepej, Snježana, et al. "Changes in T-cell subpopulations during four years of suppression of HIV-1 replication in patients with advanced disease." FEMS Immunology and Medical Microbiology, vol. 46, no. 3, 2006, pp. 351-359. https://doi.org/10.1111/j.1574-695X.2005.00034.x

Židovec Lepej, Snježana, Josip Begovac and Adriana Vince. "Changes in T-cell subpopulations during four years of suppression of HIV-1 replication in patients with advanced disease." FEMS Immunology and Medical Microbiology 46, no. 3 (2006): 351-359. https://doi.org/10.1111/j.1574-695X.2005.00034.x

Židovec Lepej, S., Begovac, J. and Vince, A. (2006) 'Changes in T-cell subpopulations during four years of suppression of HIV-1 replication in patients with advanced disease', FEMS Immunology and Medical Microbiology, 46(3), pp. 351-359. doi: 10.1111/j.1574-695X.2005.00034.x

Židovec Lepej S, Begovac J, Vince A. Changes in T-cell subpopulations during four years of suppression of HIV-1 replication in patients with advanced disease. FEMS Immunology and Medical Microbiology [Internet]. 2006 April [cited 2024 November 26];46(3):351-359. doi: 10.1111/j.1574-695X.2005.00034.x

S. Židovec Lepej, J. Begovac and A. Vince, "Changes in T-cell subpopulations during four years of suppression of HIV-1 replication in patients with advanced disease", FEMS Immunology and Medical Microbiology, vol. 46, no. 3, pp. 351-359, April 2006. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:408397. [Accessed: 26 November 2024]

Metadata
Title (english)Changes in T-cell subpopulations during four years of suppression of HIV-1 replication in patients with advanced disease
AuthorSnježana Židovec Lepej
AuthorJosip Begovac
AuthorAdriana Vince
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
We compared the number/percentages of naive and memory CD4+ T-cells, CD38+ CD8+ T-cells, and CD28+ CD4+ and CD28+ CD8+ T-cells in patients with advanced HIV disease (baseline CD4+ count < 100) with those with less advanced (baseline CD4+ cell count > 100) HIV disease during 4 years of suppressive highly active antiretroviral therapy. This prospective, longitudinal study included 30 treatment-naive patients and 32 controls. Advanced HIV-infected patients (n = 13) gained more CD4+ T-cells than less advanced patients (n = 11) at 1 month (median: 60 vs. 36 microL(-1)), 3 months (86 vs. 14), 6 months (111 vs. 23), 12 months (174 vs. 47), 24 months (162 vs. 72) and 48 months (257 vs. 123) (P = 0.15, P < 0.001, P = 0.026, P = 0.021, P = 0.1 and P = 0.06, respectively). Advanced patients gained more naive CD4+ T-cells at 48 months compared to less advanced patients (27.3 vs. 11.4%, P = 0.05). The relative gain in memory CD4+ T-cells was greater in advanced vs. less advanced patients at 1 month (median: 6.4 vs. 1.4%), 3 months (4.3 vs. 2.0), 6 months (6.7 vs. 1.6), 12 months (6.9 vs. 2.4), 24 months (7.5 vs. 3.1) and 48 months (11.3 vs. 6.8) (P = 0.002, P = 0.013, P < 0.001, P = 0.004, P = 0.001 and P = 0.015, respectively). At 48 months, CD38+ CD8+ T-cells and naive CD4+ T-cells reached normal values (9.2%, P = 0.869 vs. controls and 47.5%, P = 0.699, respectively) in less advanced patients, as did CD38+ CD8+ T-cells in advanced patients (4.7%, P = 0.309 vs. controls). The kinetics of naive and memory CD4+ T-cell reconstitution is different in less advanced compared to advanced HIV patients.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleFEMS Immunology and Medical Microbiology
Numberingvol. 46, no. 3, pp. 351-359
p-ISSN0928-8244
DOIhttps://doi.org/10.1111/j.1574-695X.2005.00034.x
URN:NBNurn:nbn:hr:105:408397
Publication2006-04
Document URLhttps://doi.org/10.1111/j.1574-695X.2005.00034.x
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 10:44:22