prikaz prve stranice dokumenta Changes in T-cell subpopulations during four years of suppression of HIV-1 replication in patients with advanced disease
  Preuzmi
PDF 189.98 KB
Znanstveni rad - Izvorni znanstveni rad
Changes in T-cell subpopulations during four years of suppression of HIV-1 replication in patients with advanced disease
FEMS Immunology and Medical Microbiology, 46 (2006), 3; 351-359. https://doi.org/10.1111/j.1574-695X.2005.00034.x
Židovec Lepej, Snježana; Begovac, Josip; Vince, Adriana

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Citirajte ovaj rad

Židovec Lepej, S., Begovac, J. i Vince, A. (2006). Changes in T-cell subpopulations during four years of suppression of HIV-1 replication in patients with advanced disease. FEMS Immunology and Medical Microbiology, 46. (3), 351-359. doi: 10.1111/j.1574-695X.2005.00034.x

Židovec Lepej, Snježana, et al. "Changes in T-cell subpopulations during four years of suppression of HIV-1 replication in patients with advanced disease." FEMS Immunology and Medical Microbiology, vol. 46, br. 3, 2006, str. 351-359. https://doi.org/10.1111/j.1574-695X.2005.00034.x

Židovec Lepej, Snježana, Josip Begovac i Adriana Vince. "Changes in T-cell subpopulations during four years of suppression of HIV-1 replication in patients with advanced disease." FEMS Immunology and Medical Microbiology 46, br. 3 (2006): 351-359. https://doi.org/10.1111/j.1574-695X.2005.00034.x

Židovec Lepej, S., Begovac, J. i Vince, A. (2006) 'Changes in T-cell subpopulations during four years of suppression of HIV-1 replication in patients with advanced disease', FEMS Immunology and Medical Microbiology, 46(3), str. 351-359. doi: 10.1111/j.1574-695X.2005.00034.x

Židovec Lepej S, Begovac J, Vince A. Changes in T-cell subpopulations during four years of suppression of HIV-1 replication in patients with advanced disease. FEMS Immunology and Medical Microbiology [Internet]. 04.2006. [pristupljeno 09.05.2024.];46(3):351-359. doi: 10.1111/j.1574-695X.2005.00034.x

S. Židovec Lepej, J. Begovac i A. Vince, "Changes in T-cell subpopulations during four years of suppression of HIV-1 replication in patients with advanced disease", FEMS Immunology and Medical Microbiology, vol. 46, br. 3, str. 351-359, Travanj 2006. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:408397. [Citirano: 09.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:408397
Podaci o radu
Naslov (engleski)Changes in T-cell subpopulations during four years of suppression of HIV-1 replication in patients with advanced disease
AutorSnježana Židovec Lepej
AutorJosip Begovac
AutorAdriana Vince
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
We compared the number/percentages of naive and memory CD4+ T-cells, CD38+ CD8+ T-cells, and CD28+ CD4+ and CD28+ CD8+ T-cells in patients with advanced HIV disease (baseline CD4+ count < 100) with those with less advanced (baseline CD4+ cell count > 100) HIV disease during 4 years of suppressive highly active antiretroviral therapy. This prospective, longitudinal study included 30 treatment-naive patients and 32 controls. Advanced HIV-infected patients (n = 13) gained more CD4+ T-cells than less advanced patients (n = 11) at 1 month (median: 60 vs. 36 microL(-1)), 3 months (86 vs. 14), 6 months (111 vs. 23), 12 months (174 vs. 47), 24 months (162 vs. 72) and 48 months (257 vs. 123) (P = 0.15, P < 0.001, P = 0.026, P = 0.021, P = 0.1 and P = 0.06, respectively). Advanced patients gained more naive CD4+ T-cells at 48 months compared to less advanced patients (27.3 vs. 11.4%, P = 0.05). The relative gain in memory CD4+ T-cells was greater in advanced vs. less advanced patients at 1 month (median: 6.4 vs. 1.4%), 3 months (4.3 vs. 2.0), 6 months (6.7 vs. 1.6), 12 months (6.9 vs. 2.4), 24 months (7.5 vs. 3.1) and 48 months (11.3 vs. 6.8) (P = 0.002, P = 0.013, P < 0.001, P = 0.004, P = 0.001 and P = 0.015, respectively). At 48 months, CD38+ CD8+ T-cells and naive CD4+ T-cells reached normal values (9.2%, P = 0.869 vs. controls and 47.5%, P = 0.699, respectively) in less advanced patients, as did CD38+ CD8+ T-cells in advanced patients (4.7%, P = 0.309 vs. controls). The kinetics of naive and memory CD4+ T-cell reconstitution is different in less advanced compared to advanced HIV patients.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaFEMS Immunology and Medical Microbiology
Brojčani podacivol. 46, br. 3, str. 351-359
p-ISSN0928-8244
DOIhttps://doi.org/10.1111/j.1574-695X.2005.00034.x
URN:NBNurn:nbn:hr:105:408397
Datum objave publikacije2006-04
URL dokumentahttps://doi.org/10.1111/j.1574-695X.2005.00034.x
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 10:44:22