Approximately 130–150 million people in the world suffer from chronic hepatitis C, and each year about 350–500 thousand people die from HCV-related liver disease and its complications. Therefore, HCV has become one of the leading public health problems. Since 1980-ies, much has been discovered about this small single-stranded RNA virus that has a spherical shape and belongs to the Flavivirida family. In the last fifteen years, the standard treatment protocol is with pegylated interferon and ribavirin. Although this protocol has quite solid results, which mostly depend on the genotype of the virus, it has not fully met the initial expectations. Still, we can already wonder if hepatitis C is a curable disease. Boceprevir and telaprevir are two viral protease inhibitors from the first generation. They belong to the so-called DAAs or direct-acting antiviral agents, they act specifically, and in combination with standard therapy they have raised the sustained virological response (SVR) in genotype 1 (which is the most spread one, but has the worst results in treatment) to a high of 80%. Lots of hopes are pinned on the two new drugs, second-generation protease inhibitors. Sofosbuvir proved quite good in combination with ribavirin in the treatment of HCV genotype 2. This dual therapy has several advantages: fewer side effects since interferon has been omitted, duration of therapy has been reduced to only 12 weeks and it is administered orally. Simeprevir has proven to be quite effective in the triple therapy with PEG-IFN and RBV in the treatment of patients with HCV genotype 1, since the duration of the therapy is reduced, there are fewer side effects and the SVR is at a high 80%. The big drawback of the new drugs is their high price.