prikaz prve stranice dokumenta The influence of 5-HT(2C) and MDR1 genetic polymorphisms on antipsychotic-induced weight gain in female schizophrenic patients
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Scientific paper - Original scientific paper
The influence of 5-HT(2C) and MDR1 genetic polymorphisms on antipsychotic-induced weight gain in female schizophrenic patients
Psychiatry Research, 160 (2008), 3; 308-315. https://doi.org/10.1016/j.psychres.2007.06.006
Rojnić Kuzman, Martina; Medved, Vesna; Božina, Nada; Hotujac, Ljubomir; Šain, Ivica; Bilušić, Hrvoje

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Rojnić Kuzman, M., Medved, V., Božina, N., Hotujac, Lj., Šain, I. & Bilušić, H. (2008). The influence of 5-HT(2C) and MDR1 genetic polymorphisms on antipsychotic-induced weight gain in female schizophrenic patients. Psychiatry Research, 160. (3), 308-315. doi: 10.1016/j.psychres.2007.06.006

Rojnić Kuzman, Martina, et al. "The influence of 5-HT(2C) and MDR1 genetic polymorphisms on antipsychotic-induced weight gain in female schizophrenic patients." Psychiatry Research, vol. 160, no. 3, 2008, pp. 308-315. https://doi.org/10.1016/j.psychres.2007.06.006

Rojnić Kuzman, Martina, Vesna Medved, Nada Božina, Ljubomir Hotujac, Ivica Šain and Hrvoje Bilušić. "The influence of 5-HT(2C) and MDR1 genetic polymorphisms on antipsychotic-induced weight gain in female schizophrenic patients." Psychiatry Research 160, no. 3 (2008): 308-315. https://doi.org/10.1016/j.psychres.2007.06.006

Rojnić Kuzman, M., et al. (2008) 'The influence of 5-HT(2C) and MDR1 genetic polymorphisms on antipsychotic-induced weight gain in female schizophrenic patients', Psychiatry Research, 160(3), pp. 308-315. doi: 10.1016/j.psychres.2007.06.006

Rojnić Kuzman M, Medved V, Božina N, Hotujac Lj, Šain I, Bilušić H. The influence of 5-HT(2C) and MDR1 genetic polymorphisms on antipsychotic-induced weight gain in female schizophrenic patients. Psychiatry Research [Internet]. 2008 September 30 [cited 2024 November 27];160(3):308-315. doi: 10.1016/j.psychres.2007.06.006

M. Rojnić Kuzman, V. Medved, N. Božina, Lj. Hotujac, I. Šain and H. Bilušić, "The influence of 5-HT(2C) and MDR1 genetic polymorphisms on antipsychotic-induced weight gain in female schizophrenic patients", Psychiatry Research, vol. 160, no. 3, pp. 308-315, September 2008. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:833007. [Accessed: 27 November 2024]

Metadata
Title (english)The influence of 5-HT(2C) and MDR1 genetic polymorphisms on antipsychotic-induced weight gain in female schizophrenic patients
AuthorMartina Rojnić Kuzman
AuthorVesna Medved
AuthorNada Božina
AuthorLjubomir Hotujac
AuthorIvica Šain
AuthorHrvoje Bilušić
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
We investigated the relationships between functional genetic variants of the 5-HT(2C) receptor and multidrug-resistant protein (MDR1), coding for P-glycoprotein, and second generation antipsychotic (SDA)-induced weight gain among 108 female schizophrenic patients treated with olanzapine or risperidone for up to 4 months. No significant differences in -759C/T allelic and genotype variants of 5-HT(2C) were found between patients who gained more than 7% of their initial weight compared with those who gained less. Haplotype-based analysis of two MDR1 loci, exon 21 G2677T and exon 26 C3435T, revealed a slightly lower representation of the G2677/C3435 haplotype in the >/=7% group. In the subgroup of patients treated with risperidone, we found borderline overrepresentation of 2677T, significant overrepresentation of 3435T variant and borderline overrepresentation of 2677T/3435T haplotype the >/=7% group, whereas G2677/C3435 haplotype was found to be less represented in the >/=7% group. Our data indicate a nonsignificant role of 759C/T 5-HT(2C) in SDA-induced weight gain, and a stronger influence of the MDR1 G2677T and C3435T polymorphisms on risperidone-induced weight gain in female schizophrenic patients. 3435T and 2677T MDR1 variants, both associated with lower P-gp function, might predispose to higher risperidone accessibility to the brain that would lead to stronger effects, including weight gain.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titlePsychiatry Research
Numberingvol. 160, no. 3, pp. 308-315
p-ISSN0165-1781
DOIhttps://doi.org/10.1016/j.psychres.2007.06.006
URN:NBNurn:nbn:hr:105:833007
Publication2008-09-30
Document URLhttps://doi.org/10.1016/j.psychres.2007.06.006
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 10:51:03