prikaz prve stranice dokumenta The influence of 5-HT(2C) and MDR1 genetic polymorphisms on antipsychotic-induced weight gain in female schizophrenic patients
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The influence of 5-HT(2C) and MDR1 genetic polymorphisms on antipsychotic-induced weight gain in female schizophrenic patients
Psychiatry Research, 160 (2008), 3; 308-315. https://doi.org/10.1016/j.psychres.2007.06.006
Rojnić Kuzman, Martina; Medved, Vesna; Božina, Nada; Hotujac, Ljubomir; Šain, Ivica; Bilušić, Hrvoje

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Citirajte ovaj rad

Rojnić Kuzman, M., Medved, V., Božina, N., Hotujac, Lj., Šain, I. i Bilušić, H. (2008). The influence of 5-HT(2C) and MDR1 genetic polymorphisms on antipsychotic-induced weight gain in female schizophrenic patients. Psychiatry Research, 160. (3), 308-315. doi: 10.1016/j.psychres.2007.06.006

Rojnić Kuzman, Martina, et al. "The influence of 5-HT(2C) and MDR1 genetic polymorphisms on antipsychotic-induced weight gain in female schizophrenic patients." Psychiatry Research, vol. 160, br. 3, 2008, str. 308-315. https://doi.org/10.1016/j.psychres.2007.06.006

Rojnić Kuzman, Martina, Vesna Medved, Nada Božina, Ljubomir Hotujac, Ivica Šain i Hrvoje Bilušić. "The influence of 5-HT(2C) and MDR1 genetic polymorphisms on antipsychotic-induced weight gain in female schizophrenic patients." Psychiatry Research 160, br. 3 (2008): 308-315. https://doi.org/10.1016/j.psychres.2007.06.006

Rojnić Kuzman, M., et al. (2008) 'The influence of 5-HT(2C) and MDR1 genetic polymorphisms on antipsychotic-induced weight gain in female schizophrenic patients', Psychiatry Research, 160(3), str. 308-315. doi: 10.1016/j.psychres.2007.06.006

Rojnić Kuzman M, Medved V, Božina N, Hotujac Lj, Šain I, Bilušić H. The influence of 5-HT(2C) and MDR1 genetic polymorphisms on antipsychotic-induced weight gain in female schizophrenic patients. Psychiatry Research [Internet]. 30.09.2008. [pristupljeno 24.11.2024.];160(3):308-315. doi: 10.1016/j.psychres.2007.06.006

M. Rojnić Kuzman, V. Medved, N. Božina, Lj. Hotujac, I. Šain i H. Bilušić, "The influence of 5-HT(2C) and MDR1 genetic polymorphisms on antipsychotic-induced weight gain in female schizophrenic patients", Psychiatry Research, vol. 160, br. 3, str. 308-315, Rujan 2008. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:833007. [Citirano: 24.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:833007
Podaci o radu
Naslov (engleski)The influence of 5-HT(2C) and MDR1 genetic polymorphisms on antipsychotic-induced weight gain in female schizophrenic patients
AutorMartina Rojnić Kuzman
AutorVesna Medved
AutorNada Božina
AutorLjubomir Hotujac
AutorIvica Šain
AutorHrvoje Bilušić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
We investigated the relationships between functional genetic variants of the 5-HT(2C) receptor and multidrug-resistant protein (MDR1), coding for P-glycoprotein, and second generation antipsychotic (SDA)-induced weight gain among 108 female schizophrenic patients treated with olanzapine or risperidone for up to 4 months. No significant differences in -759C/T allelic and genotype variants of 5-HT(2C) were found between patients who gained more than 7% of their initial weight compared with those who gained less. Haplotype-based analysis of two MDR1 loci, exon 21 G2677T and exon 26 C3435T, revealed a slightly lower representation of the G2677/C3435 haplotype in the >/=7% group. In the subgroup of patients treated with risperidone, we found borderline overrepresentation of 2677T, significant overrepresentation of 3435T variant and borderline overrepresentation of 2677T/3435T haplotype the >/=7% group, whereas G2677/C3435 haplotype was found to be less represented in the >/=7% group. Our data indicate a nonsignificant role of 759C/T 5-HT(2C) in SDA-induced weight gain, and a stronger influence of the MDR1 G2677T and C3435T polymorphisms on risperidone-induced weight gain in female schizophrenic patients. 3435T and 2677T MDR1 variants, both associated with lower P-gp function, might predispose to higher risperidone accessibility to the brain that would lead to stronger effects, including weight gain.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaPsychiatry Research
Brojčani podacivol. 160, br. 3, str. 308-315
p-ISSN0165-1781
DOIhttps://doi.org/10.1016/j.psychres.2007.06.006
URN:NBNurn:nbn:hr:105:833007
Datum objave publikacije2008-09-30
URL dokumentahttps://doi.org/10.1016/j.psychres.2007.06.006
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 10:51:03