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Scientific paper - Original scientific paper
Epilepsy due to malformations of cortical development: correlation of clinical, MRI and Tc-99mECD SPECT findings
Collegium Antropologicum, 32 (2008), 2; 345-350. urn:nbn:hr:105:094883
Sporiš, Davor; Hajnšek, Sanja; Boban, Marina; Bašić, Silvio; Petrović, Ratimir; Radoš, Marko; Babić, Tomislav

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Sporiš, D., Hajnšek, S., Boban, M., Bašić, S., Petrović, R., Radoš, M. & Babić, T. (2008). Epilepsy due to malformations of cortical development: correlation of clinical, MRI and Tc-99mECD SPECT findings. Collegium Antropologicum, 32. (2), 345-350. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:094883

Sporiš, Davor, et al. "Epilepsy due to malformations of cortical development: correlation of clinical, MRI and Tc-99mECD SPECT findings." Collegium Antropologicum, vol. 32, no. 2, 2008, pp. 345-350. https://urn.nsk.hr/urn:nbn:hr:105:094883

Sporiš, Davor, Sanja Hajnšek, Marina Boban, Silvio Bašić, Ratimir Petrović, Marko Radoš and Tomislav Babić. "Epilepsy due to malformations of cortical development: correlation of clinical, MRI and Tc-99mECD SPECT findings." Collegium Antropologicum 32, no. 2 (2008): 345-350. https://urn.nsk.hr/urn:nbn:hr:105:094883

Sporiš, D., et al. (2008) 'Epilepsy due to malformations of cortical development: correlation of clinical, MRI and Tc-99mECD SPECT findings', Collegium Antropologicum, 32(2), pp. 345-350. Available at: https://urn.nsk.hr/urn:nbn:hr:105:094883 (Accessed 29 December 2024)

Sporiš D, Hajnšek S, Boban M, Bašić S, Petrović R, Radoš M, and sur.. Epilepsy due to malformations of cortical development: correlation of clinical, MRI and Tc-99mECD SPECT findings. Collegium Antropologicum [Internet]. 2008 June [cited 2024 December 29];32(2):345-350. Available at: https://urn.nsk.hr/urn:nbn:hr:105:094883

D. Sporiš, et al., "Epilepsy due to malformations of cortical development: correlation of clinical, MRI and Tc-99mECD SPECT findings", Collegium Antropologicum, vol. 32, no. 2, pp. 345-350, June 2008. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:094883. [Accessed: 29 December 2024]

Metadata
Title (english)Epilepsy due to malformations of cortical development: correlation of clinical, MRI and Tc-99mECD SPECT findings
AuthorDavor Sporiš
AuthorSanja Hajnšek
AuthorMarina Boban
AuthorSilvio Bašić
AuthorRatimir Petrović
AuthorMarko Radoš
AuthorTomislav Babić
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Malformations of cortical development (MCD) have been increasingly recognized as an important cause of intractable epilepsy. The aim of our study was to define epileptogenicity of MCDs by correlating MRI, EEG and semiology of epileptic attacks, and to determine the effect of MCD on drug resistant epilepsy. We also intended to reveal the utility of interictal single photo emission computed tomography (SPECT) in verification of MCD lesions and relative prevalence of different MCDs. Based on interictal EEG finding, semiology of the epileptic attacks and brain magnetic resonance imaging (MRI) "electroclinical epileptogenicity" of MCD was defined. Brain MRI revealed cortical dysplasia (CD) in nine patients, polymicrogyria in four patients, lissencephaly and schizencephaly in one patient each. Three patients had a combination of malformations. The localization of SPECT hypoperfusion corresponded to MCD lesion in ten (66.67%) patients. Electroclinically confirmed epileptogenicity of MCD overlapped with MR and interictal SPECT findings in fourteen (93.3%) and nine (60.0%) patients, respectively. Our study results demonstrated the MCD lesions to be highly epileptogenic and a frequent cause of intractability.
Abstract (croatian)
Malformacije kortikalnog razvoja (MKR) sve se više raspoznaju kao važan uzrok farmakorezistentne epilepsije. Cilj studije bio je utvrditi epileptogenost MKR korelirajući MRI, EET i simptomatologiju epileptičnih napada, te odrediti povezanost MKR na farmakorezistentnost epilepsije. Također je namjera bila utvrditi korisnost interiktalne pretrage SPECT-a za potvrdu proširenosti MRK i relativnu učestalost različitih tipova MKR. Simptomatologija epileptičnih napada i »elektroklinička epileptogenost« MKR prema nalazu MRI mozga utvrđene su na osnovi interiktalnih nalaza EEG. MRI mozga je otkrila kortikalnu displaziju u devetoro bolesnika, polimikrogiriju u četvoro bolesnika, te lisencefaliju i shizencefaliju u po jednog bolesnika, dok je troje bolesnika imalo kombinaciju različitih malformacija. Lokalizacija hipoperfuzije na SPECT-u odgovarala je oštećenju MKR u desetoro (66,67%) bolesnika. Elektroklinički potvrđena epileptogenost MKR preklapala se s nalazima MRI i interiktalnog SPECT u četrnaestoro (93,3%) odnosno devetoro (60,0%) bolesnika. Naši su nalazi pokazali kako su MKR visoko epileptogena i čest razlog farmakorezistentnosti u bolesnika sa epilepsijom.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium Antropologicum
Numberingvol. 32, no. 2, pp. 345-350
p-ISSN0350-6134
URN:NBNurn:nbn:hr:105:094883
Publication2008-06
Document URLhttps://hrcak.srce.hr/27216
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 11:06:11