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Epilepsy due to malformations of cortical development: correlation of clinical, MRI and Tc-99mECD SPECT findings
Collegium Antropologicum, 32 (2008), 2; 345-350. urn:nbn:hr:105:094883
Sporiš, Davor; Hajnšek, Sanja; Boban, Marina; Bašić, Silvio; Petrović, Ratimir; Radoš, Marko; Babić, Tomislav

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Sporiš, D., Hajnšek, S., Boban, M., Bašić, S., Petrović, R., Radoš, M. i Babić, T. (2008). Epilepsy due to malformations of cortical development: correlation of clinical, MRI and Tc-99mECD SPECT findings. Collegium Antropologicum, 32. (2), 345-350. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:105:094883

Sporiš, Davor, et al. "Epilepsy due to malformations of cortical development: correlation of clinical, MRI and Tc-99mECD SPECT findings." Collegium Antropologicum, vol. 32, br. 2, 2008, str. 345-350. https://urn.nsk.hr/urn:nbn:hr:105:094883

Sporiš, Davor, Sanja Hajnšek, Marina Boban, Silvio Bašić, Ratimir Petrović, Marko Radoš i Tomislav Babić. "Epilepsy due to malformations of cortical development: correlation of clinical, MRI and Tc-99mECD SPECT findings." Collegium Antropologicum 32, br. 2 (2008): 345-350. https://urn.nsk.hr/urn:nbn:hr:105:094883

Sporiš, D., et al. (2008) 'Epilepsy due to malformations of cortical development: correlation of clinical, MRI and Tc-99mECD SPECT findings', Collegium Antropologicum, 32(2), str. 345-350. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:105:094883 (Datum pristupa: 04.05.2024.)

Sporiš D, Hajnšek S, Boban M, Bašić S, Petrović R, Radoš M, i sur.. Epilepsy due to malformations of cortical development: correlation of clinical, MRI and Tc-99mECD SPECT findings. Collegium Antropologicum [Internet]. 06.2008. [pristupljeno 04.05.2024.];32(2):345-350. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:094883

D. Sporiš, et al., "Epilepsy due to malformations of cortical development: correlation of clinical, MRI and Tc-99mECD SPECT findings", Collegium Antropologicum, vol. 32, br. 2, str. 345-350, Lipanj 2008. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:094883. [Citirano: 04.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:094883
Podaci o radu
Naslov (engleski)Epilepsy due to malformations of cortical development: correlation of clinical, MRI and Tc-99mECD SPECT findings
AutorDavor Sporiš
AutorSanja Hajnšek
AutorMarina Boban
AutorSilvio Bašić
AutorRatimir Petrović
AutorMarko Radoš
AutorTomislav Babić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Malformations of cortical development (MCD) have been increasingly recognized as an important cause of intractable epilepsy. The aim of our study was to define epileptogenicity of MCDs by correlating MRI, EEG and semiology of epileptic attacks, and to determine the effect of MCD on drug resistant epilepsy. We also intended to reveal the utility of interictal single photo emission computed tomography (SPECT) in verification of MCD lesions and relative prevalence of different MCDs. Based on interictal EEG finding, semiology of the epileptic attacks and brain magnetic resonance imaging (MRI) "electroclinical epileptogenicity" of MCD was defined. Brain MRI revealed cortical dysplasia (CD) in nine patients, polymicrogyria in four patients, lissencephaly and schizencephaly in one patient each. Three patients had a combination of malformations. The localization of SPECT hypoperfusion corresponded to MCD lesion in ten (66.67%) patients. Electroclinically confirmed epileptogenicity of MCD overlapped with MR and interictal SPECT findings in fourteen (93.3%) and nine (60.0%) patients, respectively. Our study results demonstrated the MCD lesions to be highly epileptogenic and a frequent cause of intractability.
Sažetak (hrvatski)
Malformacije kortikalnog razvoja (MKR) sve se više raspoznaju kao važan uzrok farmakorezistentne epilepsije. Cilj studije bio je utvrditi epileptogenost MKR korelirajući MRI, EET i simptomatologiju epileptičnih napada, te odrediti povezanost MKR na farmakorezistentnost epilepsije. Također je namjera bila utvrditi korisnost interiktalne pretrage SPECT-a za potvrdu proširenosti MRK i relativnu učestalost različitih tipova MKR. Simptomatologija epileptičnih napada i »elektroklinička epileptogenost« MKR prema nalazu MRI mozga utvrđene su na osnovi interiktalnih nalaza EEG. MRI mozga je otkrila kortikalnu displaziju u devetoro bolesnika, polimikrogiriju u četvoro bolesnika, te lisencefaliju i shizencefaliju u po jednog bolesnika, dok je troje bolesnika imalo kombinaciju različitih malformacija. Lokalizacija hipoperfuzije na SPECT-u odgovarala je oštećenju MKR u desetoro (66,67%) bolesnika. Elektroklinički potvrđena epileptogenost MKR preklapala se s nalazima MRI i interiktalnog SPECT u četrnaestoro (93,3%) odnosno devetoro (60,0%) bolesnika. Naši su nalazi pokazali kako su MKR visoko epileptogena i čest razlog farmakorezistentnosti u bolesnika sa epilepsijom.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCollegium Antropologicum
Brojčani podacivol. 32, br. 2, str. 345-350
p-ISSN0350-6134
URN:NBNurn:nbn:hr:105:094883
Datum objave publikacije2008-06
URL dokumentahttps://hrcak.srce.hr/27216
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 11:06:11