prikaz prve stranice dokumenta Historic, demographic, and genetic evidence for increased population frequencies of CCR5Delta32 mutation in Croatian Island isolates after lethal 15th century epidemics
  Download
PDF 279.14 KB
Scientific paper - Original scientific paper
Historic, demographic, and genetic evidence for increased population frequencies of CCR5Delta32 mutation in Croatian Island isolates after lethal 15th century epidemics
Croatian medical journal, 50 (2009), 1; 34-42. https://doi.org/10.3325/cmj.2009.50.34
Biloglav, Zrinka; Zgaga, Lina; Smoljanović, Mladen; Hayward, Caroline; Polašek, Ozren; Kolčić, Ivana; Vitart, Veronique; Zemunik, Tatijana; Boraska, Vesna; Torlak, Vesela; Mulić, Rosanda; Ropac, Darko; Grković, Ivica; Rudan, Diana; Ristić, Smiljana; Barbalić, Maja; Campbell, Harry; Wright, Alan F.; Rudan, Igor More authors...

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Biloglav, Z., Zgaga, L., Smoljanović, M., Hayward, C., Polašek, O., Kolčić, I. ... Rudan, I. (2009). Historic, demographic, and genetic evidence for increased population frequencies of CCR5Delta32 mutation in Croatian Island isolates after lethal 15th century epidemics. Croatian medical journal, 50. (1), 34-42. doi: 10.3325/cmj.2009.50.34

Biloglav, Zrinka, et al. "Historic, demographic, and genetic evidence for increased population frequencies of CCR5Delta32 mutation in Croatian Island isolates after lethal 15th century epidemics." Croatian medical journal, vol. 50, no. 1, 2009, pp. 34-42. https://doi.org/10.3325/cmj.2009.50.34

Biloglav, Zrinka, Lina Zgaga, Mladen Smoljanović, Caroline Hayward, Ozren Polašek, Ivana Kolčić, Veronique Vitart, et al. "Historic, demographic, and genetic evidence for increased population frequencies of CCR5Delta32 mutation in Croatian Island isolates after lethal 15th century epidemics." Croatian medical journal 50, no. 1 (2009): 34-42. https://doi.org/10.3325/cmj.2009.50.34

Biloglav, Z., et al. (2009) 'Historic, demographic, and genetic evidence for increased population frequencies of CCR5Delta32 mutation in Croatian Island isolates after lethal 15th century epidemics', Croatian medical journal, 50(1), pp. 34-42. doi: 10.3325/cmj.2009.50.34

Biloglav Z, Zgaga L, Smoljanović M, Hayward C, Polašek O, Kolčić I, and sur.. Historic, demographic, and genetic evidence for increased population frequencies of CCR5Delta32 mutation in Croatian Island isolates after lethal 15th century epidemics. Croatian medical journal [Internet]. 2009 February [cited 2024 April 30];50(1):34-42. doi: 10.3325/cmj.2009.50.34

Z. Biloglav, et al., "Historic, demographic, and genetic evidence for increased population frequencies of CCR5Delta32 mutation in Croatian Island isolates after lethal 15th century epidemics", Croatian medical journal, vol. 50, no. 1, pp. 34-42, February 2009. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:116808. [Accessed: 30 April 2024]

Metadata
Title (english)Historic, demographic, and genetic evidence for increased population frequencies of CCR5Delta32 mutation in Croatian Island isolates after lethal 15th century epidemics
AuthorZrinka Biloglav
AuthorLina Zgaga
AuthorMladen Smoljanović
AuthorCaroline Hayward
AuthorOzren Polašek
AuthorIvana Kolčić
AuthorVeronique Vitart
AuthorTatijana Zemunik
AuthorVesna Boraska
AuthorVesela Torlak
AuthorRosanda Mulić
AuthorDarko Ropac
AuthorIvica Grković
AuthorDiana Rudan
AuthorSmiljana Ristić
AuthorMaja Barbalić
AuthorHarry Campbell
AuthorAlan F. Wright
AuthorIgor Rudan
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Public Health and Health Care
Abstract (english)
AIM: To assess the frequency of 32 base pair deletion in CCR5 (CCR5Delta32), which has been shown to confer resistance to HIV infection in a homozygous form, in 10 isolated island communities of Dalmatia, Croatia, with different histories of exposure to epidemics during and since the medieval period. ----- METHODS: In 2002, DNA analysis of 100 randomly selected individuals from each of the 10 isolated communities of 5 Croatian islands (Susak, Rab, Vis, Lastovo, and Mljet) showed high levels of 3-generational endogamy, indicating limited gene flow. Five of the communities were decimated by epidemics of unknown cause between 1449-1456, while the other 5 villages remained unaffected. Genotyping of the CCR5 gene was performed using the polymerase chain reaction method with primers flanking the region containing 32-bp deletion. ----- RESULTS: The frequency of CCR5Delta32 in the 5 villages affected by the epidemic was 6.1-10.0%, and 1.0-3.8% in the 5 unaffected villages. The Delta32 mutation was found in 71 of 916 alleles among the individuals from the affected villages (7.5%), and in 24 of 968 alleles in unaffected villages (2.5%, chi(2)=27.3, P<10-6). A previous study in 303 random Croatian blood donors showed the frequency of the CCR5 Delta32 of 7.1% in the general population. The difference remained significant after correcting for population structure using both STRAT and STRUCTURE software and the genomic control test, to ensure results do not arise from the background genetic differences. ----- CONCLUSION: Our results and historical evidence, suggest that the mid-15th century epidemic could have acted as a selection pressure for the CCR5Delta32 mutation.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCroatian medical journal
Numberingvol. 50, no. 1, pp. 34-42
p-ISSN0353-9504
DOIhttps://doi.org/10.3325/cmj.2009.50.34
URN:NBNurn:nbn:hr:105:116808
Publication2009-02
Document URLhttp://www.cmj.hr/2009/50/1/19260142.htm
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 11:14:32