prikaz prve stranice dokumenta Historic, demographic, and genetic evidence for increased population frequencies of CCR5Delta32 mutation in Croatian Island isolates after lethal 15th century epidemics
  Preuzmi
PDF 279.14 KB
Znanstveni rad - Izvorni znanstveni rad
Historic, demographic, and genetic evidence for increased population frequencies of CCR5Delta32 mutation in Croatian Island isolates after lethal 15th century epidemics
Croatian medical journal, 50 (2009), 1; 34-42. https://doi.org/10.3325/cmj.2009.50.34
Biloglav, Zrinka; Zgaga, Lina; Smoljanović, Mladen; Hayward, Caroline; Polašek, Ozren; Kolčić, Ivana; Vitart, Veronique; Zemunik, Tatijana; Boraska, Vesna; Torlak, Vesela; Mulić, Rosanda; Ropac, Darko; Grković, Ivica; Rudan, Diana; Ristić, Smiljana; Barbalić, Maja; Campbell, Harry; Wright, Alan F.; Rudan, Igor Više autora...

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Citirajte ovaj rad

Biloglav, Z., Zgaga, L., Smoljanović, M., Hayward, C., Polašek, O., Kolčić, I. ... Rudan, I. (2009). Historic, demographic, and genetic evidence for increased population frequencies of CCR5Delta32 mutation in Croatian Island isolates after lethal 15th century epidemics. Croatian medical journal, 50. (1), 34-42. doi: 10.3325/cmj.2009.50.34

Biloglav, Zrinka, et al. "Historic, demographic, and genetic evidence for increased population frequencies of CCR5Delta32 mutation in Croatian Island isolates after lethal 15th century epidemics." Croatian medical journal, vol. 50, br. 1, 2009, str. 34-42. https://doi.org/10.3325/cmj.2009.50.34

Biloglav, Zrinka, Lina Zgaga, Mladen Smoljanović, Caroline Hayward, Ozren Polašek, Ivana Kolčić, Veronique Vitart, et al. "Historic, demographic, and genetic evidence for increased population frequencies of CCR5Delta32 mutation in Croatian Island isolates after lethal 15th century epidemics." Croatian medical journal 50, br. 1 (2009): 34-42. https://doi.org/10.3325/cmj.2009.50.34

Biloglav, Z., et al. (2009) 'Historic, demographic, and genetic evidence for increased population frequencies of CCR5Delta32 mutation in Croatian Island isolates after lethal 15th century epidemics', Croatian medical journal, 50(1), str. 34-42. doi: 10.3325/cmj.2009.50.34

Biloglav Z, Zgaga L, Smoljanović M, Hayward C, Polašek O, Kolčić I, i sur.. Historic, demographic, and genetic evidence for increased population frequencies of CCR5Delta32 mutation in Croatian Island isolates after lethal 15th century epidemics. Croatian medical journal [Internet]. 02.2009. [pristupljeno 26.11.2024.];50(1):34-42. doi: 10.3325/cmj.2009.50.34

Z. Biloglav, et al., "Historic, demographic, and genetic evidence for increased population frequencies of CCR5Delta32 mutation in Croatian Island isolates after lethal 15th century epidemics", Croatian medical journal, vol. 50, br. 1, str. 34-42, Veljača 2009. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:116808. [Citirano: 26.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:116808
Podaci o radu
Naslov (engleski)Historic, demographic, and genetic evidence for increased population frequencies of CCR5Delta32 mutation in Croatian Island isolates after lethal 15th century epidemics
AutorZrinka Biloglav
AutorLina Zgaga
AutorMladen Smoljanović
AutorCaroline Hayward
AutorOzren Polašek
AutorIvana Kolčić
AutorVeronique Vitart
AutorTatijana Zemunik
AutorVesna Boraska
AutorVesela Torlak
AutorRosanda Mulić
AutorDarko Ropac
AutorIvica Grković
AutorDiana Rudan
AutorSmiljana Ristić
AutorMaja Barbalić
AutorHarry Campbell
AutorAlan F. Wright
AutorIgor Rudan
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Javno zdravstvo i zdravstvena zaštita
Sažetak (engleski)
AIM: To assess the frequency of 32 base pair deletion in CCR5 (CCR5Delta32), which has been shown to confer resistance to HIV infection in a homozygous form, in 10 isolated island communities of Dalmatia, Croatia, with different histories of exposure to epidemics during and since the medieval period. ----- METHODS: In 2002, DNA analysis of 100 randomly selected individuals from each of the 10 isolated communities of 5 Croatian islands (Susak, Rab, Vis, Lastovo, and Mljet) showed high levels of 3-generational endogamy, indicating limited gene flow. Five of the communities were decimated by epidemics of unknown cause between 1449-1456, while the other 5 villages remained unaffected. Genotyping of the CCR5 gene was performed using the polymerase chain reaction method with primers flanking the region containing 32-bp deletion. ----- RESULTS: The frequency of CCR5Delta32 in the 5 villages affected by the epidemic was 6.1-10.0%, and 1.0-3.8% in the 5 unaffected villages. The Delta32 mutation was found in 71 of 916 alleles among the individuals from the affected villages (7.5%), and in 24 of 968 alleles in unaffected villages (2.5%, chi(2)=27.3, P<10-6). A previous study in 303 random Croatian blood donors showed the frequency of the CCR5 Delta32 of 7.1% in the general population. The difference remained significant after correcting for population structure using both STRAT and STRUCTURE software and the genomic control test, to ensure results do not arise from the background genetic differences. ----- CONCLUSION: Our results and historical evidence, suggest that the mid-15th century epidemic could have acted as a selection pressure for the CCR5Delta32 mutation.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCroatian medical journal
Brojčani podacivol. 50, br. 1, str. 34-42
p-ISSN0353-9504
DOIhttps://doi.org/10.3325/cmj.2009.50.34
URN:NBNurn:nbn:hr:105:116808
Datum objave publikacije2009-02
URL dokumentahttp://www.cmj.hr/2009/50/1/19260142.htm
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 11:14:32