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Scientific paper - Original scientific paper
The shape of the aortic outflow velocity profile revisited: is there a relation between its asymmetry and ventricular function in coronary artery disease?
European Journal of Echocardiography, 10 (2009), 7; 847-857. https://doi.org/10.1093/ejechocard/jep088
Čikeš, Maja; Kalinić, Hrvoje; Baltabaeva, Aigul; Lončarić, Sven; Parsai, Chirine; Miličić, Davor; Čikeš, Ivo; Sutherland, George; Bijnens, Bart

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Čikeš, M., Kalinić, H., Baltabaeva, A., Lončarić, S., Parsai, C., Miličić, D. ... Bijnens, B. (2009). The shape of the aortic outflow velocity profile revisited: is there a relation between its asymmetry and ventricular function in coronary artery disease? . European Journal of Echocardiography, 10. (7), 847-857. doi: 10.1093/ejechocard/jep088

Čikeš, Maja, et al. "The shape of the aortic outflow velocity profile revisited: is there a relation between its asymmetry and ventricular function in coronary artery disease? ." European Journal of Echocardiography, vol. 10, no. 7, 2009, pp. 847-857. https://doi.org/10.1093/ejechocard/jep088

Čikeš, Maja, Hrvoje Kalinić, Aigul Baltabaeva, Sven Lončarić, Chirine Parsai, Davor Miličić, Ivo Čikeš, George Sutherland and Bart Bijnens. "The shape of the aortic outflow velocity profile revisited: is there a relation between its asymmetry and ventricular function in coronary artery disease? ." European Journal of Echocardiography 10, no. 7 (2009): 847-857. https://doi.org/10.1093/ejechocard/jep088

Čikeš, M., et al. (2009) 'The shape of the aortic outflow velocity profile revisited: is there a relation between its asymmetry and ventricular function in coronary artery disease? ', European Journal of Echocardiography, 10(7), pp. 847-857. doi: 10.1093/ejechocard/jep088

Čikeš M, Kalinić H, Baltabaeva A, Lončarić S, Parsai C, Miličić D, and sur.. The shape of the aortic outflow velocity profile revisited: is there a relation between its asymmetry and ventricular function in coronary artery disease? . European Journal of Echocardiography [Internet]. 2009 June 16 [cited 2025 January 14];10(7):847-857. doi: 10.1093/ejechocard/jep088

M. Čikeš, et al., "The shape of the aortic outflow velocity profile revisited: is there a relation between its asymmetry and ventricular function in coronary artery disease? ", European Journal of Echocardiography, vol. 10, no. 7, pp. 847-857, June 2009. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:347556. [Accessed: 14 January 2025]

Metadata
Title (english)The shape of the aortic outflow velocity profile revisited: is there a relation between its asymmetry and ventricular function in coronary artery disease?
AuthorMaja Čikeš
AuthorHrvoje Kalinić
AuthorAigul Baltabaeva
AuthorSven Lončarić
AuthorChirine Parsai
AuthorDavor Miličić
AuthorIvo Čikeš
AuthorGeorge Sutherland
AuthorBart Bijnens
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
AIMS: Myocardium contracts in the beginning of ejection causing outflow acceleration, resulting in asymmetric outflow velocity profiles peaking around one-third of ejection and declining when force development declines. This article aimed to demonstrate that decreased contractility in coronary artery disease (CAD) changes outflow timing and profile symmetry. ----- METHODS AND RESULTS: Seventy-nine patients undergoing routine full dose dobutamine stress-echo (DSE) were divided into two groups based on resting wall motion and DSE response: DSE negative (DSE(neg)) (35 of 79 patients) and positive (DSE(pos)) (44 of 79 patients) which were compared with 32 healthy volunteers. Aortic CW-Doppler traces at rest were analysed semi-automatically; time-to-peak (T(mod)), ejection-time (ET(mod)), rise-time (t(rise)), and fall-time (t(fall)) were quantified. Asymmetry (asymm) was calculated as the normalized difference of left and right half of the spectrum. Normal curves were triangular, early-peaking, whereas patients showed more rounded shapes and later peaks. T(rise) was longest in DSE(pos). T(fall) was shortest in DSE(pos), followed by controls and DSE(neg). Asymm was lowest in DSE(pos), followed by controls and DSE(neg). Abnormally symmetric profiles (asymm <0.25) were found in none of the controls, 2.9% DSE(neg), and 27.3% DSE(pos). A good correlation was found between assym and ejection fraction (EF) and T(mod)/ET(mod) and EF. Notably, an LV dynamic gradient was induced in 71.4% DSE(neg) and in 18.2% DSE(pos), associated with LV hypertrophy and supernormal (very asymmetric) traces. ----- CONCLUSION: Decreased myocardial function results in a more symmetrical outflow, while very asymmetrical traces suggest increased contractility, potentially inducing intra-cavity gradients during DSE. Therefore, including outflow symmetry as a clinical measurement provides additional information on patients with CAD.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleEuropean Journal of Echocardiography
Numberingvol. 10, no. 7, pp. 847-857
p-ISSN1525-2167
DOIhttps://doi.org/10.1093/ejechocard/jep088
URN:NBNurn:nbn:hr:105:347556
Publication2009-06-16
Document URLhttps://doi.org/10.1093/ejechocard/jep088
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 11:23:35