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The shape of the aortic outflow velocity profile revisited: is there a relation between its asymmetry and ventricular function in coronary artery disease?
European Journal of Echocardiography, 10 (2009), 7; 847-857. https://doi.org/10.1093/ejechocard/jep088
Čikeš, Maja; Kalinić, Hrvoje; Baltabaeva, Aigul; Lončarić, Sven; Parsai, Chirine; Miličić, Davor; Čikeš, Ivo; Sutherland, George; Bijnens, Bart

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Citirajte ovaj rad

Čikeš, M., Kalinić, H., Baltabaeva, A., Lončarić, S., Parsai, C., Miličić, D. ... Bijnens, B. (2009). The shape of the aortic outflow velocity profile revisited: is there a relation between its asymmetry and ventricular function in coronary artery disease? . European Journal of Echocardiography, 10. (7), 847-857. doi: 10.1093/ejechocard/jep088

Čikeš, Maja, et al. "The shape of the aortic outflow velocity profile revisited: is there a relation between its asymmetry and ventricular function in coronary artery disease? ." European Journal of Echocardiography, vol. 10, br. 7, 2009, str. 847-857. https://doi.org/10.1093/ejechocard/jep088

Čikeš, Maja, Hrvoje Kalinić, Aigul Baltabaeva, Sven Lončarić, Chirine Parsai, Davor Miličić, Ivo Čikeš, George Sutherland i Bart Bijnens. "The shape of the aortic outflow velocity profile revisited: is there a relation between its asymmetry and ventricular function in coronary artery disease? ." European Journal of Echocardiography 10, br. 7 (2009): 847-857. https://doi.org/10.1093/ejechocard/jep088

Čikeš, M., et al. (2009) 'The shape of the aortic outflow velocity profile revisited: is there a relation between its asymmetry and ventricular function in coronary artery disease? ', European Journal of Echocardiography, 10(7), str. 847-857. doi: 10.1093/ejechocard/jep088

Čikeš M, Kalinić H, Baltabaeva A, Lončarić S, Parsai C, Miličić D, i sur.. The shape of the aortic outflow velocity profile revisited: is there a relation between its asymmetry and ventricular function in coronary artery disease? . European Journal of Echocardiography [Internet]. 16.06.2009. [pristupljeno 26.12.2024.];10(7):847-857. doi: 10.1093/ejechocard/jep088

M. Čikeš, et al., "The shape of the aortic outflow velocity profile revisited: is there a relation between its asymmetry and ventricular function in coronary artery disease? ", European Journal of Echocardiography, vol. 10, br. 7, str. 847-857, Lipanj 2009. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:347556. [Citirano: 26.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:347556
Podaci o radu
Naslov (engleski)The shape of the aortic outflow velocity profile revisited: is there a relation between its asymmetry and ventricular function in coronary artery disease?
AutorMaja Čikeš
AutorHrvoje Kalinić
AutorAigul Baltabaeva
AutorSven Lončarić
AutorChirine Parsai
AutorDavor Miličić
AutorIvo Čikeš
AutorGeorge Sutherland
AutorBart Bijnens
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
AIMS: Myocardium contracts in the beginning of ejection causing outflow acceleration, resulting in asymmetric outflow velocity profiles peaking around one-third of ejection and declining when force development declines. This article aimed to demonstrate that decreased contractility in coronary artery disease (CAD) changes outflow timing and profile symmetry. ----- METHODS AND RESULTS: Seventy-nine patients undergoing routine full dose dobutamine stress-echo (DSE) were divided into two groups based on resting wall motion and DSE response: DSE negative (DSE(neg)) (35 of 79 patients) and positive (DSE(pos)) (44 of 79 patients) which were compared with 32 healthy volunteers. Aortic CW-Doppler traces at rest were analysed semi-automatically; time-to-peak (T(mod)), ejection-time (ET(mod)), rise-time (t(rise)), and fall-time (t(fall)) were quantified. Asymmetry (asymm) was calculated as the normalized difference of left and right half of the spectrum. Normal curves were triangular, early-peaking, whereas patients showed more rounded shapes and later peaks. T(rise) was longest in DSE(pos). T(fall) was shortest in DSE(pos), followed by controls and DSE(neg). Asymm was lowest in DSE(pos), followed by controls and DSE(neg). Abnormally symmetric profiles (asymm <0.25) were found in none of the controls, 2.9% DSE(neg), and 27.3% DSE(pos). A good correlation was found between assym and ejection fraction (EF) and T(mod)/ET(mod) and EF. Notably, an LV dynamic gradient was induced in 71.4% DSE(neg) and in 18.2% DSE(pos), associated with LV hypertrophy and supernormal (very asymmetric) traces. ----- CONCLUSION: Decreased myocardial function results in a more symmetrical outflow, while very asymmetrical traces suggest increased contractility, potentially inducing intra-cavity gradients during DSE. Therefore, including outflow symmetry as a clinical measurement provides additional information on patients with CAD.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaEuropean Journal of Echocardiography
Brojčani podacivol. 10, br. 7, str. 847-857
p-ISSN1525-2167
DOIhttps://doi.org/10.1093/ejechocard/jep088
URN:NBNurn:nbn:hr:105:347556
Datum objave publikacije2009-06-16
URL dokumentahttps://doi.org/10.1093/ejechocard/jep088
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 11:23:35