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Scientific paper - Original scientific paper
Platelet serotonin concentration and monoamine oxidase type B activity in female patients in early, middle and late phase of Alzheimer’s disease
Progress in Neuro-Psychopharmacology & Biological Psychiatry, 33 (2009), 7; 1226-1231. https://doi.org/10.1016/j.pnpbp.2009.07.004
Mück-Šeler, Dorotea; Presečki, Paola; Mimica, Ninoslav; Mustapić, Maja; Pivac, Nela; Babić, Ana; Nedić, Gordana; Folnegović-Šmalc, Vera

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Mück Šeler, D., Presečki, P., Mimica, N., Mustapić, M., Pivac, N., Babić, A. ... Folnegović Šmalc, V. (2009). Platelet serotonin concentration and monoamine oxidase type B activity in female patients in early, middle and late phase of Alzheimer’s disease . Progress in Neuro-Psychopharmacology & Biological Psychiatry, 33. (7), 1226-1231. doi: 10.1016/j.pnpbp.2009.07.004

Mück Šeler, Dorotea, et al. "Platelet serotonin concentration and monoamine oxidase type B activity in female patients in early, middle and late phase of Alzheimer’s disease ." Progress in Neuro-Psychopharmacology & Biological Psychiatry, vol. 33, no. 7, 2009, pp. 1226-1231. https://doi.org/10.1016/j.pnpbp.2009.07.004

Mück Šeler, Dorotea, Paola Presečki, Ninoslav Mimica, Maja Mustapić, Nela Pivac, Ana Babić, Gordana Nedić and Vera Folnegović Šmalc. "Platelet serotonin concentration and monoamine oxidase type B activity in female patients in early, middle and late phase of Alzheimer’s disease ." Progress in Neuro-Psychopharmacology & Biological Psychiatry 33, no. 7 (2009): 1226-1231. https://doi.org/10.1016/j.pnpbp.2009.07.004

Mück Šeler, D., et al. (2009) 'Platelet serotonin concentration and monoamine oxidase type B activity in female patients in early, middle and late phase of Alzheimer’s disease ', Progress in Neuro-Psychopharmacology & Biological Psychiatry, 33(7), pp. 1226-1231. doi: 10.1016/j.pnpbp.2009.07.004

Mück Šeler D, Presečki P, Mimica N, Mustapić M, Pivac N, Babić A, and sur.. Platelet serotonin concentration and monoamine oxidase type B activity in female patients in early, middle and late phase of Alzheimer’s disease . Progress in Neuro-Psychopharmacology & Biological Psychiatry [Internet]. 2009 October 01 [cited 2024 May 03];33(7):1226-1231. doi: 10.1016/j.pnpbp.2009.07.004

D. Mück Šeler, et al., "Platelet serotonin concentration and monoamine oxidase type B activity in female patients in early, middle and late phase of Alzheimer’s disease ", Progress in Neuro-Psychopharmacology & Biological Psychiatry, vol. 33, no. 7, pp. 1226-1231, October 2009. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:454983. [Accessed: 03 May 2024]

Metadata
Title (english)Platelet serotonin concentration and monoamine oxidase type B activity in female patients in early, middle and late phase of Alzheimer’s disease
AuthorDorotea Mück-Šeler
AuthorPaola Presečki
AuthorNinoslav Mimica
AuthorMaja Mustapić
AuthorNela Pivac
AuthorAna Babić
AuthorGordana Nedić
AuthorVera Folnegović-Šmalc
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Alzheimer’s disease (AD) is a progressive, neurodegenerative disorder with unclear etiology. Cognitive impairment in AD might be associated with altered serotonergic system. The aim of the study was to determine platelet serotonin (5-HT) concentrations and platelet monoamine oxidase type B (MAO-B) activity in patients with different severity of AD. Platelet 5-HT concentrations and MAO-B activity were determined spectrofluorimetrically in 74 female patients with AD (NINCDS-ADRDA, DSM-IV-TR criteria), subdivided according to the Mini Mental State Examination (MMSE) scores in three groups with a) 23 patients in early (MMSE scores 19-24), b) 23 patients in middle (MMSE 10-18), and c) 28 patients in late (MMSE 0-9) phase of AD, and in 49 age-matched healthy women. Platelet 5-HT concentrations and MAO-B activity were similar between all patients with AD and healthy subjects, but were significantly lower in patients in the late phase of AD than in other phases of AD, and in healthy controls. The significant correlations were found between MMSE scores and platelet 5-HT concentrations, MAO-B activity and age. Lower platelet 5-HT concentration and MAO-B activity in the late phase of AD suggested that these markers might indicate severity and/or clinical progress of AD.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleProgress in Neuro-Psychopharmacology & Biological Psychiatry
Numberingvol. 33, no. 7, pp. 1226-1231
p-ISSN0278-5846
DOIhttps://doi.org/10.1016/j.pnpbp.2009.07.004
URN:NBNurn:nbn:hr:105:454983
Publication2009-10-01
Document URLhttps://doi.org/10.1016/j.pnpbp.2009.07.004
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 11:26:44