prikaz prve stranice dokumenta Platelet serotonin concentration and monoamine oxidase type B activity in female patients in early, middle and late phase of Alzheimer’s disease
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Platelet serotonin concentration and monoamine oxidase type B activity in female patients in early, middle and late phase of Alzheimer’s disease
Progress in Neuro-Psychopharmacology & Biological Psychiatry, 33 (2009), 7; 1226-1231. https://doi.org/10.1016/j.pnpbp.2009.07.004
Mück-Šeler, Dorotea; Presečki, Paola; Mimica, Ninoslav; Mustapić, Maja; Pivac, Nela; Babić, Ana; Nedić, Gordana; Folnegović-Šmalc, Vera

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Mück Šeler, D., Presečki, P., Mimica, N., Mustapić, M., Pivac, N., Babić, A. ... Folnegović Šmalc, V. (2009). Platelet serotonin concentration and monoamine oxidase type B activity in female patients in early, middle and late phase of Alzheimer’s disease . Progress in Neuro-Psychopharmacology & Biological Psychiatry, 33. (7), 1226-1231. doi: 10.1016/j.pnpbp.2009.07.004

Mück Šeler, Dorotea, et al. "Platelet serotonin concentration and monoamine oxidase type B activity in female patients in early, middle and late phase of Alzheimer’s disease ." Progress in Neuro-Psychopharmacology & Biological Psychiatry, vol. 33, br. 7, 2009, str. 1226-1231. https://doi.org/10.1016/j.pnpbp.2009.07.004

Mück Šeler, Dorotea, Paola Presečki, Ninoslav Mimica, Maja Mustapić, Nela Pivac, Ana Babić, Gordana Nedić i Vera Folnegović Šmalc. "Platelet serotonin concentration and monoamine oxidase type B activity in female patients in early, middle and late phase of Alzheimer’s disease ." Progress in Neuro-Psychopharmacology & Biological Psychiatry 33, br. 7 (2009): 1226-1231. https://doi.org/10.1016/j.pnpbp.2009.07.004

Mück Šeler, D., et al. (2009) 'Platelet serotonin concentration and monoamine oxidase type B activity in female patients in early, middle and late phase of Alzheimer’s disease ', Progress in Neuro-Psychopharmacology & Biological Psychiatry, 33(7), str. 1226-1231. doi: 10.1016/j.pnpbp.2009.07.004

Mück Šeler D, Presečki P, Mimica N, Mustapić M, Pivac N, Babić A, i sur.. Platelet serotonin concentration and monoamine oxidase type B activity in female patients in early, middle and late phase of Alzheimer’s disease . Progress in Neuro-Psychopharmacology & Biological Psychiatry [Internet]. 01.10.2009. [pristupljeno 04.05.2024.];33(7):1226-1231. doi: 10.1016/j.pnpbp.2009.07.004

D. Mück Šeler, et al., "Platelet serotonin concentration and monoamine oxidase type B activity in female patients in early, middle and late phase of Alzheimer’s disease ", Progress in Neuro-Psychopharmacology & Biological Psychiatry, vol. 33, br. 7, str. 1226-1231, Listopad 2009. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:454983. [Citirano: 04.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:454983
Podaci o radu
Naslov (engleski)Platelet serotonin concentration and monoamine oxidase type B activity in female patients in early, middle and late phase of Alzheimer’s disease
AutorDorotea Mück-Šeler
AutorPaola Presečki
AutorNinoslav Mimica
AutorMaja Mustapić
AutorNela Pivac
AutorAna Babić
AutorGordana Nedić
AutorVera Folnegović-Šmalc
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Alzheimer’s disease (AD) is a progressive, neurodegenerative disorder with unclear etiology. Cognitive impairment in AD might be associated with altered serotonergic system. The aim of the study was to determine platelet serotonin (5-HT) concentrations and platelet monoamine oxidase type B (MAO-B) activity in patients with different severity of AD. Platelet 5-HT concentrations and MAO-B activity were determined spectrofluorimetrically in 74 female patients with AD (NINCDS-ADRDA, DSM-IV-TR criteria), subdivided according to the Mini Mental State Examination (MMSE) scores in three groups with a) 23 patients in early (MMSE scores 19-24), b) 23 patients in middle (MMSE 10-18), and c) 28 patients in late (MMSE 0-9) phase of AD, and in 49 age-matched healthy women. Platelet 5-HT concentrations and MAO-B activity were similar between all patients with AD and healthy subjects, but were significantly lower in patients in the late phase of AD than in other phases of AD, and in healthy controls. The significant correlations were found between MMSE scores and platelet 5-HT concentrations, MAO-B activity and age. Lower platelet 5-HT concentration and MAO-B activity in the late phase of AD suggested that these markers might indicate severity and/or clinical progress of AD.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaProgress in Neuro-Psychopharmacology & Biological Psychiatry
Brojčani podacivol. 33, br. 7, str. 1226-1231
p-ISSN0278-5846
DOIhttps://doi.org/10.1016/j.pnpbp.2009.07.004
URN:NBNurn:nbn:hr:105:454983
Datum objave publikacije2009-10-01
URL dokumentahttps://doi.org/10.1016/j.pnpbp.2009.07.004
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 11:26:44