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Scientific paper - Case study
Patient with neuromyelitis optica and inflammatory demyelinating lesions comprising whole spinal cord from C2 level till conus: case report
BMC Neurology, 9 (2009), 56; https://doi.org/10.1186/1471-2377-9-56
Petelin Gadže, Željka; Hajnšek, Sanja; Bašić, Silvio; Sporiš, Davor; Pavliša, Goran; Nanković, Sibila

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Petelin Gadže, Ž., Hajnšek, S., Bašić, S., Sporiš, D., Pavliša, G. & Nanković, S. (2009). Patient with neuromyelitis optica and inflammatory demyelinating lesions comprising whole spinal cord from C2 level till conus: case report. BMC Neurology, 9. (56). doi: 10.1186/1471-2377-9-56

Petelin Gadže, Željka, et al. "Patient with neuromyelitis optica and inflammatory demyelinating lesions comprising whole spinal cord from C2 level till conus: case report." BMC Neurology, vol. 9, no. 56, 2009. https://doi.org/10.1186/1471-2377-9-56

Petelin Gadže, Željka, Sanja Hajnšek, Silvio Bašić, Davor Sporiš, Goran Pavliša and Sibila Nanković. "Patient with neuromyelitis optica and inflammatory demyelinating lesions comprising whole spinal cord from C2 level till conus: case report." BMC Neurology 9, no. 56 (2009). https://doi.org/10.1186/1471-2377-9-56

Petelin Gadže, Ž., et al. (2009) 'Patient with neuromyelitis optica and inflammatory demyelinating lesions comprising whole spinal cord from C2 level till conus: case report', BMC Neurology, 9(56). doi: 10.1186/1471-2377-9-56

Petelin Gadže Ž, Hajnšek S, Bašić S, Sporiš D, Pavliša G, Nanković S. Patient with neuromyelitis optica and inflammatory demyelinating lesions comprising whole spinal cord from C2 level till conus: case report. BMC Neurology [Internet]. 2009 October 23 [cited 2024 May 19];9(56). doi: 10.1186/1471-2377-9-56

Ž. Petelin Gadže, S. Hajnšek, S. Bašić, D. Sporiš, G. Pavliša and S. Nanković, "Patient with neuromyelitis optica and inflammatory demyelinating lesions comprising whole spinal cord from C2 level till conus: case report", BMC Neurology, vol. 9, no. 56, October 2009. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:183139. [Accessed: 19 May 2024]

Metadata
Title (english)Patient with neuromyelitis optica and inflammatory demyelinating lesions comprising whole spinal cord from C2 level till conus: case report
AuthorŽeljka Petelin Gadže
AuthorSanja Hajnšek
AuthorSilvio Bašić
AuthorDavor Sporiš
AuthorGoran Pavliša
AuthorSibila Nanković
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
BACKGROUND: Neuromyelitis optica (NMO) is an idiopathic, severe, inflammatory demyelinating disease of the central nervous system, that causes severe optic neuritis and myelitis attacks. Early discrimination between multiple sclerosis (MS) and NMO is important, as optimum treatment for both diseases may differ considerably. ----- CASE PRESENTATION: We report a case of a patient who initially presented as longitudinally extensive transverse myelitis (LETM), having spastic upper extremities diparesis and spastic paraplegia, C2/C3 sensory level and urinary incontinence, as well as extensive inflammatory spinal cord lesions from C2 level to conus. After 5 months the patient had another attack of transverse myelitis, had electrophysiological findings consistent with optic neuritis, was seropositive for NMO-IgG (aquaporin-4 IgG) and thus fulfilled NMO diagnostic criteria. Following treatment of disease attacks with pulse corticosteroid therapy and intravenous immunoglobulins, we included oral azathioprine in a combination with oral prednisone in the therapy. Since there was no significant clinical improvement, we decided to use cyclophosphamide therapy, which resulted in good clinical improvement and gradual decrease of cord swelling. ----- CONCLUSION: In this NMO case report we wanted to emphasize the extensiveness of inflammatory spinal cord changes in our patient, from C2 level to conus. In the conclusion it is important to say that accurate, early diagnosis and distinction from MS is critical to facilitate initiation of immunosuppressive therapy for attack prevention.
Keywords (english)
Languageenglish
Publication typeScientific paper - Case study
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBMC Neurology
Numberingvol. 9, no. 56
p-ISSN1471-2377
DOIhttps://doi.org/10.1186/1471-2377-9-56
URN:NBNurn:nbn:hr:105:183139
Publication2009-10-23
Document URLhttps://doi.org/10.1186/1471-2377-9-56
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 11:28:21