prikaz prve stranice dokumenta Bone morphogenetic proteins and receptors are over-expressed in bone-marrow cells of multiple myeloma patients and support myeloma cells by inducing ID genes
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Scientific paper - Original scientific paper
Bone morphogenetic proteins and receptors are over-expressed in bone-marrow cells of multiple myeloma patients and support myeloma cells by inducing ID genes
Leukemia Research, 34 (2010), 6; 742-751. https://doi.org/10.1016/j.leukres.2009.10.016
Grčević, Danka; Kušec, Rajko; Kovačić, Nataša; Lukić, Anita; Lukić, Ivan Krešimir; Ivčević, Sanja; Nemet, Damir; Serventi Seiwerth, Ranka; Kolonić Ostojić, Slobodanka; Croucher, Peter I; Marušić, Ana

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Grčević, D., Kušec, R., Kovačić, N., Lukić, A., Lukić, I. K., Ivčević, S. ... Marušić, A. (2010). Bone morphogenetic proteins and receptors are over-expressed in bone-marrow cells of multiple myeloma patients and support myeloma cells by inducing ID genes. Leukemia Research, 34. (6), 742-751. doi: 10.1016/j.leukres.2009.10.016

Grčević, Danka, et al. "Bone morphogenetic proteins and receptors are over-expressed in bone-marrow cells of multiple myeloma patients and support myeloma cells by inducing ID genes." Leukemia Research, vol. 34, no. 6, 2010, pp. 742-751. https://doi.org/10.1016/j.leukres.2009.10.016

Grčević, Danka, Rajko Kušec, Nataša Kovačić, Anita Lukić, Ivan Krešimir Lukić, Sanja Ivčević, Damir Nemet, et al. "Bone morphogenetic proteins and receptors are over-expressed in bone-marrow cells of multiple myeloma patients and support myeloma cells by inducing ID genes." Leukemia Research 34, no. 6 (2010): 742-751. https://doi.org/10.1016/j.leukres.2009.10.016

Grčević, D., et al. (2010) 'Bone morphogenetic proteins and receptors are over-expressed in bone-marrow cells of multiple myeloma patients and support myeloma cells by inducing ID genes', Leukemia Research, 34(6), pp. 742-751. doi: 10.1016/j.leukres.2009.10.016

Grčević D, Kušec R, Kovačić N, Lukić A, Lukić IK, Ivčević S, and sur.. Bone morphogenetic proteins and receptors are over-expressed in bone-marrow cells of multiple myeloma patients and support myeloma cells by inducing ID genes. Leukemia Research [Internet]. 2010 June [cited 2024 November 22];34(6):742-751. doi: 10.1016/j.leukres.2009.10.016

D. Grčević, et al., "Bone morphogenetic proteins and receptors are over-expressed in bone-marrow cells of multiple myeloma patients and support myeloma cells by inducing ID genes", Leukemia Research, vol. 34, no. 6, pp. 742-751, June 2010. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:564907. [Accessed: 22 November 2024]

Metadata
Title (english)Bone morphogenetic proteins and receptors are over-expressed in bone-marrow cells of multiple myeloma patients and support myeloma cells by inducing ID genes
AuthorDanka Grčević
AuthorRajko Kušec
AuthorNataša Kovačić
AuthorAnita Lukić
AuthorIvan Krešimir Lukić
AuthorSanja Ivčević
AuthorDamir Nemet
AuthorRanka Serventi Seiwerth
AuthorSlobodanka Kolonić Ostojić
AuthorPeter I Croucher
AuthorAna Marušić
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
We assessed the expression pattern and clinical relevance of BMPs and related molecules in multiple myeloma (MM). MM bone-marrow samples (n=32) had increased BMP4, BMP6, ACVR1 and ACVR2A, and decreased NOG expression compared with controls (n=15), with BMP6 having the highest sensitivity/specificity. Within MM bone-marrow, the source of BMPs was mainly CD138(+) plasma-cell population, and BMP6 and ACVR1 expression correlated with plasma-cell percentage. Using myeloma cell lines NCI H929 and Thiel we showed that BMPs induced ID1, ID2 and IL6, and suppressed CDKN1A and BAX gene expression, and BAX protein expression. Finally, BMPs partially protected myeloma cells from bortezomib- and TRAIL-induced apoptosis. We concluded that BMPs may be involved in MM pathophysiology and serve as myeloma cell biomarkers.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleLeukemia Research
Numberingvol. 34, no. 6, pp. 742-751
p-ISSN0145-2126
DOIhttps://doi.org/10.1016/j.leukres.2009.10.016
URN:NBNurn:nbn:hr:105:564907
Publication2010-06
Document URLhttps://doi.org/10.1016/j.leukres.2009.10.016
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 11:29:57