prikaz prve stranice dokumenta Bone morphogenetic proteins and receptors are over-expressed in bone-marrow cells of multiple myeloma patients and support myeloma cells by inducing ID genes
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Bone morphogenetic proteins and receptors are over-expressed in bone-marrow cells of multiple myeloma patients and support myeloma cells by inducing ID genes
Leukemia Research, 34 (2010), 6; 742-751. https://doi.org/10.1016/j.leukres.2009.10.016
Grčević, Danka; Kušec, Rajko; Kovačić, Nataša; Lukić, Anita; Lukić, Ivan Krešimir; Ivčević, Sanja; Nemet, Damir; Serventi Seiwerth, Ranka; Kolonić Ostojić, Slobodanka; Croucher, Peter I; Marušić, Ana

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Citirajte ovaj rad

Grčević, D., Kušec, R., Kovačić, N., Lukić, A., Lukić, I. K., Ivčević, S. ... Marušić, A. (2010). Bone morphogenetic proteins and receptors are over-expressed in bone-marrow cells of multiple myeloma patients and support myeloma cells by inducing ID genes. Leukemia Research, 34. (6), 742-751. doi: 10.1016/j.leukres.2009.10.016

Grčević, Danka, et al. "Bone morphogenetic proteins and receptors are over-expressed in bone-marrow cells of multiple myeloma patients and support myeloma cells by inducing ID genes." Leukemia Research, vol. 34, br. 6, 2010, str. 742-751. https://doi.org/10.1016/j.leukres.2009.10.016

Grčević, Danka, Rajko Kušec, Nataša Kovačić, Anita Lukić, Ivan Krešimir Lukić, Sanja Ivčević, Damir Nemet, et al. "Bone morphogenetic proteins and receptors are over-expressed in bone-marrow cells of multiple myeloma patients and support myeloma cells by inducing ID genes." Leukemia Research 34, br. 6 (2010): 742-751. https://doi.org/10.1016/j.leukres.2009.10.016

Grčević, D., et al. (2010) 'Bone morphogenetic proteins and receptors are over-expressed in bone-marrow cells of multiple myeloma patients and support myeloma cells by inducing ID genes', Leukemia Research, 34(6), str. 742-751. doi: 10.1016/j.leukres.2009.10.016

Grčević D, Kušec R, Kovačić N, Lukić A, Lukić IK, Ivčević S, i sur.. Bone morphogenetic proteins and receptors are over-expressed in bone-marrow cells of multiple myeloma patients and support myeloma cells by inducing ID genes. Leukemia Research [Internet]. 06.2010. [pristupljeno 27.12.2024.];34(6):742-751. doi: 10.1016/j.leukres.2009.10.016

D. Grčević, et al., "Bone morphogenetic proteins and receptors are over-expressed in bone-marrow cells of multiple myeloma patients and support myeloma cells by inducing ID genes", Leukemia Research, vol. 34, br. 6, str. 742-751, Lipanj 2010. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:564907. [Citirano: 27.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:564907
Podaci o radu
Naslov (engleski)Bone morphogenetic proteins and receptors are over-expressed in bone-marrow cells of multiple myeloma patients and support myeloma cells by inducing ID genes
AutorDanka Grčević
AutorRajko Kušec
AutorNataša Kovačić
AutorAnita Lukić
AutorIvan Krešimir Lukić
AutorSanja Ivčević
AutorDamir Nemet
AutorRanka Serventi Seiwerth
AutorSlobodanka Kolonić Ostojić
AutorPeter I Croucher
AutorAna Marušić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
We assessed the expression pattern and clinical relevance of BMPs and related molecules in multiple myeloma (MM). MM bone-marrow samples (n=32) had increased BMP4, BMP6, ACVR1 and ACVR2A, and decreased NOG expression compared with controls (n=15), with BMP6 having the highest sensitivity/specificity. Within MM bone-marrow, the source of BMPs was mainly CD138(+) plasma-cell population, and BMP6 and ACVR1 expression correlated with plasma-cell percentage. Using myeloma cell lines NCI H929 and Thiel we showed that BMPs induced ID1, ID2 and IL6, and suppressed CDKN1A and BAX gene expression, and BAX protein expression. Finally, BMPs partially protected myeloma cells from bortezomib- and TRAIL-induced apoptosis. We concluded that BMPs may be involved in MM pathophysiology and serve as myeloma cell biomarkers.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaLeukemia Research
Brojčani podacivol. 34, br. 6, str. 742-751
p-ISSN0145-2126
DOIhttps://doi.org/10.1016/j.leukres.2009.10.016
URN:NBNurn:nbn:hr:105:564907
Datum objave publikacije2010-06
URL dokumentahttps://doi.org/10.1016/j.leukres.2009.10.016
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 11:29:57