prikaz prve stranice dokumenta Molecular genetic alterations of FHIT and p53 genes in benign and malignant thyroid gland lesions
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Scientific paper - Original scientific paper
Molecular genetic alterations of FHIT and p53 genes in benign and malignant thyroid gland lesions
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 599 (2006), 1-2; 45-57. https://doi.org/10.1016/j.mrfmmm.2006.01.021
Pavelić, Krešimir; Dedivitis, Rogerio A.; Kapitanović, Sanja; Čačev, Tamara; Guirado, Cristiano R.; Danić, Davor; Radošević, Senka; Brkić, Kornelije; Pegan, Boris; Križanac, Šimun; Kusić, Zvonko; Spaventi, Šime; Bura, Miljenko

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Pavelić, K., Dedivitis, R. A., Kapitanović, S., Čačev, T., Guirado, C. R., Danić, D. ... Bura, M. (2006). Molecular genetic alterations of FHIT and p53 genes in benign and malignant thyroid gland lesions. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 599. (1-2), 45-57. doi: 10.1016/j.mrfmmm.2006.01.021

Pavelić, Krešimir, et al. "Molecular genetic alterations of FHIT and p53 genes in benign and malignant thyroid gland lesions." Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, vol. 599, no. 1-2, 2006, pp. 45-57. https://doi.org/10.1016/j.mrfmmm.2006.01.021

Pavelić, Krešimir, Rogerio A. Dedivitis, Sanja Kapitanović, Tamara Čačev, Cristiano R. Guirado, Davor Danić, Senka Radošević, et al. "Molecular genetic alterations of FHIT and p53 genes in benign and malignant thyroid gland lesions." Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis 599, no. 1-2 (2006): 45-57. https://doi.org/10.1016/j.mrfmmm.2006.01.021

Pavelić, K., et al. (2006) 'Molecular genetic alterations of FHIT and p53 genes in benign and malignant thyroid gland lesions', Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 599(1-2), pp. 45-57. doi: 10.1016/j.mrfmmm.2006.01.021

Pavelić K, Dedivitis RA, Kapitanović S, Čačev T, Guirado CR, Danić D, and sur.. Molecular genetic alterations of FHIT and p53 genes in benign and malignant thyroid gland lesions. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis [Internet]. 2006 July 25 [cited 2024 July 13];599(1-2):45-57. doi: 10.1016/j.mrfmmm.2006.01.021

K. Pavelić, et al., "Molecular genetic alterations of FHIT and p53 genes in benign and malignant thyroid gland lesions", Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, vol. 599, no. 1-2, pp. 45-57, July 2006. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:345353. [Accessed: 13 July 2024]

Metadata
Title (english)Molecular genetic alterations of FHIT and p53 genes in benign and malignant thyroid gland lesions
AuthorKrešimir Pavelić
AuthorRogerio A. Dedivitis
AuthorSanja Kapitanović
AuthorTamara Čačev
AuthorCristiano R. Guirado
AuthorDavor Danić
AuthorSenka Radošević
AuthorKornelije Brkić
AuthorBoris Pegan
AuthorŠimun Križanac
AuthorZvonko Kusić
AuthorŠime Spaventi
AuthorMiljenko Bura
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Several oncogenes and tumor-suppressor genes are involved either as early or late event in thyroid gland carcinogenesis. Human FHIT (fragile histidine triad) gene is highly conserved gene whose loss of function may be important in the development and/or progression of various types of cancer. We undertook this study to analyze FHIT and p53 gene status in different benignant and malignant thyroid tumors. Status of these genes as well as intensity of apoptosis was analyzed in tumor tissues by molecular genetic methods, immunohistochemistry, and FACS-scan analysis. The majority of the malignant thyroid cancers displayed aberrant expression of FHIT gene, concominant with p53 gene inactivation. This is followed by low rate of apoptosis, which may be important in the development and/or progression of thyroid cancer. We found higher incidence of p53 mutation and aberrant processing of FHIT mRNA in malignant tumors (papillary, follicular, medullary and anaplastic carcinomas) and i! n those tumors with distant metastasis. The growth of p53(-)/FHIT- follicular carcinoma of human origin was much faster in nude mice than p53(+)/FHIT- follicular carcinoma, and mice had shorter survival rate. Our results show a correlation between aberrant FHIT and p53 expression, low rate of apoptosis, and malignancy. Concomitant aberration of FHIT gene and p53 could be responsible for development of highly malignant types of thyroid cancer and may be considered as a prognostic marker for these tumors.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Numberingvol. 599, no. 1-2, pp. 45-57
p-ISSN0027-5107
DOIhttps://doi.org/10.1016/j.mrfmmm.2006.01.021
URN:NBNurn:nbn:hr:105:345353
Publication2006-07-25
Document URLhttps://doi.org/10.1016/j.mrfmmm.2006.01.021
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 11:32:12