prikaz prve stranice dokumenta Molecular genetic alterations of FHIT and p53 genes in benign and malignant thyroid gland lesions
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Molecular genetic alterations of FHIT and p53 genes in benign and malignant thyroid gland lesions
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 599 (2006), 1-2; 45-57. https://doi.org/10.1016/j.mrfmmm.2006.01.021
Pavelić, Krešimir; Dedivitis, Rogerio A.; Kapitanović, Sanja; Čačev, Tamara; Guirado, Cristiano R.; Danić, Davor; Radošević, Senka; Brkić, Kornelije; Pegan, Boris; Križanac, Šimun; Kusić, Zvonko; Spaventi, Šime; Bura, Miljenko

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Citirajte ovaj rad

Pavelić, K., Dedivitis, R. A., Kapitanović, S., Čačev, T., Guirado, C. R., Danić, D. ... Bura, M. (2006). Molecular genetic alterations of FHIT and p53 genes in benign and malignant thyroid gland lesions. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 599. (1-2), 45-57. doi: 10.1016/j.mrfmmm.2006.01.021

Pavelić, Krešimir, et al. "Molecular genetic alterations of FHIT and p53 genes in benign and malignant thyroid gland lesions." Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, vol. 599, br. 1-2, 2006, str. 45-57. https://doi.org/10.1016/j.mrfmmm.2006.01.021

Pavelić, Krešimir, Rogerio A. Dedivitis, Sanja Kapitanović, Tamara Čačev, Cristiano R. Guirado, Davor Danić, Senka Radošević, et al. "Molecular genetic alterations of FHIT and p53 genes in benign and malignant thyroid gland lesions." Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis 599, br. 1-2 (2006): 45-57. https://doi.org/10.1016/j.mrfmmm.2006.01.021

Pavelić, K., et al. (2006) 'Molecular genetic alterations of FHIT and p53 genes in benign and malignant thyroid gland lesions', Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 599(1-2), str. 45-57. doi: 10.1016/j.mrfmmm.2006.01.021

Pavelić K, Dedivitis RA, Kapitanović S, Čačev T, Guirado CR, Danić D, i sur.. Molecular genetic alterations of FHIT and p53 genes in benign and malignant thyroid gland lesions. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis [Internet]. 25.07.2006. [pristupljeno 14.05.2024.];599(1-2):45-57. doi: 10.1016/j.mrfmmm.2006.01.021

K. Pavelić, et al., "Molecular genetic alterations of FHIT and p53 genes in benign and malignant thyroid gland lesions", Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, vol. 599, br. 1-2, str. 45-57, Srpanj 2006. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:345353. [Citirano: 14.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:345353
Podaci o radu
Naslov (engleski)Molecular genetic alterations of FHIT and p53 genes in benign and malignant thyroid gland lesions
AutorKrešimir Pavelić
AutorRogerio A. Dedivitis
AutorSanja Kapitanović
AutorTamara Čačev
AutorCristiano R. Guirado
AutorDavor Danić
AutorSenka Radošević
AutorKornelije Brkić
AutorBoris Pegan
AutorŠimun Križanac
AutorZvonko Kusić
AutorŠime Spaventi
AutorMiljenko Bura
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Several oncogenes and tumor-suppressor genes are involved either as early or late event in thyroid gland carcinogenesis. Human FHIT (fragile histidine triad) gene is highly conserved gene whose loss of function may be important in the development and/or progression of various types of cancer. We undertook this study to analyze FHIT and p53 gene status in different benignant and malignant thyroid tumors. Status of these genes as well as intensity of apoptosis was analyzed in tumor tissues by molecular genetic methods, immunohistochemistry, and FACS-scan analysis. The majority of the malignant thyroid cancers displayed aberrant expression of FHIT gene, concominant with p53 gene inactivation. This is followed by low rate of apoptosis, which may be important in the development and/or progression of thyroid cancer. We found higher incidence of p53 mutation and aberrant processing of FHIT mRNA in malignant tumors (papillary, follicular, medullary and anaplastic carcinomas) and i! n those tumors with distant metastasis. The growth of p53(-)/FHIT- follicular carcinoma of human origin was much faster in nude mice than p53(+)/FHIT- follicular carcinoma, and mice had shorter survival rate. Our results show a correlation between aberrant FHIT and p53 expression, low rate of apoptosis, and malignancy. Concomitant aberration of FHIT gene and p53 could be responsible for development of highly malignant types of thyroid cancer and may be considered as a prognostic marker for these tumors.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Brojčani podacivol. 599, br. 1-2, str. 45-57
p-ISSN0027-5107
DOIhttps://doi.org/10.1016/j.mrfmmm.2006.01.021
URN:NBNurn:nbn:hr:105:345353
Datum objave publikacije2006-07-25
URL dokumentahttps://doi.org/10.1016/j.mrfmmm.2006.01.021
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 11:32:12