prikaz prve stranice dokumenta Expression of chemokine receptor CX3CR1 in infants with respiratory syncytial virus bronchiolitis
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Scientific paper - Original scientific paper
Expression of chemokine receptor CX3CR1 in infants with respiratory syncytial virus bronchiolitis
Pediatric Allergy and Immunology, 19 (2008), 2; 148-156. https://doi.org/10.1111/j.1399-3038.2007.00611.x
Cepika, Alma-Martina; Gagro, Alenka; Baće, Ana; Tješić-Drinković, Dorian; Kelečić, Jadranka; Baričić-Voskresensky, Tamara; Matić, Mladen; Draženović, Vladimir; Marinić, Igor; Mlinarić-Galinović, Gordana; Tješić-Drinković, Duška; Vrtar, Zvonimir; Rabatić, Sabina

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Cepika, A. M., Gagro, A., Baće, A., Tješić Drinković, D., Kelečić, J., Baričić Voskresensky, T. ... Rabatić, S. (2008). Expression of chemokine receptor CX3CR1 in infants with respiratory syncytial virus bronchiolitis. Pediatric Allergy and Immunology, 19. (2), 148-156. doi: 10.1111/j.1399-3038.2007.00611.x

Cepika, Alma Martina, et al. "Expression of chemokine receptor CX3CR1 in infants with respiratory syncytial virus bronchiolitis." Pediatric Allergy and Immunology, vol. 19, no. 2, 2008, pp. 148-156. https://doi.org/10.1111/j.1399-3038.2007.00611.x

Cepika, Alma Martina, Alenka Gagro, Ana Baće, Dorian Tješić Drinković, Jadranka Kelečić, Tamara Baričić Voskresensky, Mladen Matić, et al. "Expression of chemokine receptor CX3CR1 in infants with respiratory syncytial virus bronchiolitis." Pediatric Allergy and Immunology 19, no. 2 (2008): 148-156. https://doi.org/10.1111/j.1399-3038.2007.00611.x

Cepika, A. M., et al. (2008) 'Expression of chemokine receptor CX3CR1 in infants with respiratory syncytial virus bronchiolitis', Pediatric Allergy and Immunology, 19(2), pp. 148-156. doi: 10.1111/j.1399-3038.2007.00611.x

Cepika AM, Gagro A, Baće A, Tješić Drinković D, Kelečić J, Baričić Voskresensky T, and sur.. Expression of chemokine receptor CX3CR1 in infants with respiratory syncytial virus bronchiolitis. Pediatric Allergy and Immunology [Internet]. 2008 March [cited 2024 November 27];19(2):148-156. doi: 10.1111/j.1399-3038.2007.00611.x

A. M. Cepika, et al., "Expression of chemokine receptor CX3CR1 in infants with respiratory syncytial virus bronchiolitis", Pediatric Allergy and Immunology, vol. 19, no. 2, pp. 148-156, March 2008. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:586429. [Accessed: 27 November 2024]

Metadata
Title (english)Expression of chemokine receptor CX3CR1 in infants with respiratory syncytial virus bronchiolitis
AuthorAlma-Martina Cepika
AuthorAlenka Gagro
AuthorAna Baće
AuthorDorian Tješić-Drinković
AuthorJadranka Kelečić
AuthorTamara Baričić-Voskresensky
AuthorMladen Matić
AuthorVladimir Draženović
AuthorIgor Marinić
AuthorGordana Mlinarić-Galinović
AuthorDuška Tješić-Drinković
AuthorZvonimir Vrtar
AuthorSabina Rabatić
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Respiratory syncytial virus (RSV) glycoprotein G mimics fractalkine, a CX(3)C chemokine, which mediates chemotaxis of leukocytes expressing its receptor, CX(3)CR1. The aim of this study was to examine the relationship between RSV infection and expression of perforin and IFN-gamma in CX(3)CR1-expressing peripheral blood CD8(+) T cells. Samples were collected from infants with RSV bronchiolitis, both in the acute and convalescence phase (n = 12), and from their age- and sex-matched healthy controls (n = 15). Perforin expression and IFN-gamma secretion in CX(3)CR1(+) CD8(+) T cells were assessed by four-color flow cytometry. The NF-kappaB p50 and p65 subunit levels were also determined as markers of RSV-induced inflammation. Study results showed perforin and CX(3)CR1 expression to be significantly lower in the convalescent phase of infected infants than in healthy controls. There was no significant difference in IFN-gamma secretion and NF-kappaB binding activity between two time-points in RSV-infected infants, or when compared with healthy controls. Infants with prolonged wheezing had lower acute-phase CX(3)CR1 levels in peripheral blood. These data indicate existence of an event persisting after acute RSV infection that is able to modulate effector functions of cytotoxic T cells, and also link disease severity with CX(3)CR1 expression.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titlePediatric Allergy and Immunology
Numberingvol. 19, no. 2, pp. 148-156
p-ISSN0905-6157
DOIhttps://doi.org/10.1111/j.1399-3038.2007.00611.x
URN:NBNurn:nbn:hr:105:586429
Publication2008-03
Document URLhttps://doi.org/10.1111/j.1399-3038.2007.00611.x
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 11:34:11