prikaz prve stranice dokumenta Expression of chemokine receptor CX3CR1 in infants with respiratory syncytial virus bronchiolitis
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Expression of chemokine receptor CX3CR1 in infants with respiratory syncytial virus bronchiolitis
Pediatric Allergy and Immunology, 19 (2008), 2; 148-156. https://doi.org/10.1111/j.1399-3038.2007.00611.x
Cepika, Alma-Martina; Gagro, Alenka; Baće, Ana; Tješić-Drinković, Dorian; Kelečić, Jadranka; Baričić-Voskresensky, Tamara; Matić, Mladen; Draženović, Vladimir; Marinić, Igor; Mlinarić-Galinović, Gordana; Tješić-Drinković, Duška; Vrtar, Zvonimir; Rabatić, Sabina

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Cepika, A. M., Gagro, A., Baće, A., Tješić Drinković, D., Kelečić, J., Baričić Voskresensky, T. ... Rabatić, S. (2008). Expression of chemokine receptor CX3CR1 in infants with respiratory syncytial virus bronchiolitis. Pediatric Allergy and Immunology, 19. (2), 148-156. doi: 10.1111/j.1399-3038.2007.00611.x

Cepika, Alma Martina, et al. "Expression of chemokine receptor CX3CR1 in infants with respiratory syncytial virus bronchiolitis." Pediatric Allergy and Immunology, vol. 19, br. 2, 2008, str. 148-156. https://doi.org/10.1111/j.1399-3038.2007.00611.x

Cepika, Alma Martina, Alenka Gagro, Ana Baće, Dorian Tješić Drinković, Jadranka Kelečić, Tamara Baričić Voskresensky, Mladen Matić, et al. "Expression of chemokine receptor CX3CR1 in infants with respiratory syncytial virus bronchiolitis." Pediatric Allergy and Immunology 19, br. 2 (2008): 148-156. https://doi.org/10.1111/j.1399-3038.2007.00611.x

Cepika, A. M., et al. (2008) 'Expression of chemokine receptor CX3CR1 in infants with respiratory syncytial virus bronchiolitis', Pediatric Allergy and Immunology, 19(2), str. 148-156. doi: 10.1111/j.1399-3038.2007.00611.x

Cepika AM, Gagro A, Baće A, Tješić Drinković D, Kelečić J, Baričić Voskresensky T, i sur.. Expression of chemokine receptor CX3CR1 in infants with respiratory syncytial virus bronchiolitis. Pediatric Allergy and Immunology [Internet]. 03.2008. [pristupljeno 28.04.2024.];19(2):148-156. doi: 10.1111/j.1399-3038.2007.00611.x

A. M. Cepika, et al., "Expression of chemokine receptor CX3CR1 in infants with respiratory syncytial virus bronchiolitis", Pediatric Allergy and Immunology, vol. 19, br. 2, str. 148-156, Ožujak 2008. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:586429. [Citirano: 28.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:586429
Podaci o radu
Naslov (engleski)Expression of chemokine receptor CX3CR1 in infants with respiratory syncytial virus bronchiolitis
AutorAlma-Martina Cepika
AutorAlenka Gagro
AutorAna Baće
AutorDorian Tješić-Drinković
AutorJadranka Kelečić
AutorTamara Baričić-Voskresensky
AutorMladen Matić
AutorVladimir Draženović
AutorIgor Marinić
AutorGordana Mlinarić-Galinović
AutorDuška Tješić-Drinković
AutorZvonimir Vrtar
AutorSabina Rabatić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Respiratory syncytial virus (RSV) glycoprotein G mimics fractalkine, a CX(3)C chemokine, which mediates chemotaxis of leukocytes expressing its receptor, CX(3)CR1. The aim of this study was to examine the relationship between RSV infection and expression of perforin and IFN-gamma in CX(3)CR1-expressing peripheral blood CD8(+) T cells. Samples were collected from infants with RSV bronchiolitis, both in the acute and convalescence phase (n = 12), and from their age- and sex-matched healthy controls (n = 15). Perforin expression and IFN-gamma secretion in CX(3)CR1(+) CD8(+) T cells were assessed by four-color flow cytometry. The NF-kappaB p50 and p65 subunit levels were also determined as markers of RSV-induced inflammation. Study results showed perforin and CX(3)CR1 expression to be significantly lower in the convalescent phase of infected infants than in healthy controls. There was no significant difference in IFN-gamma secretion and NF-kappaB binding activity between two time-points in RSV-infected infants, or when compared with healthy controls. Infants with prolonged wheezing had lower acute-phase CX(3)CR1 levels in peripheral blood. These data indicate existence of an event persisting after acute RSV infection that is able to modulate effector functions of cytotoxic T cells, and also link disease severity with CX(3)CR1 expression.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaPediatric Allergy and Immunology
Brojčani podacivol. 19, br. 2, str. 148-156
p-ISSN0905-6157
DOIhttps://doi.org/10.1111/j.1399-3038.2007.00611.x
URN:NBNurn:nbn:hr:105:586429
Datum objave publikacije2008-03
URL dokumentahttps://doi.org/10.1111/j.1399-3038.2007.00611.x
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 11:34:11