prikaz prve stranice dokumenta Periacinar clefting and p63 immunostaining in prostatic intraepithelial neoplasia and prostatic carcinoma
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Scientific paper - Original scientific paper
Periacinar clefting and p63 immunostaining in prostatic intraepithelial neoplasia and prostatic carcinoma
Pathology Oncology Research, 12 (2006), 4; 205-209. https://doi.org/10.1007/BF02893413
Krušlin, Božo; Tomas, Davor; Cviko, Aida; Čupić, Hrvoje; Odak, Ljubica; Belicza, Mladen

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Krušlin, B., Tomas, D., Cviko, A., Čupić, H., Odak, Lj. & Belicza, M. (2006). Periacinar clefting and p63 immunostaining in prostatic intraepithelial neoplasia and prostatic carcinoma. Pathology Oncology Research, 12. (4), 205-209. doi: 10.1007/BF02893413

Krušlin, Božo, et al. "Periacinar clefting and p63 immunostaining in prostatic intraepithelial neoplasia and prostatic carcinoma." Pathology Oncology Research, vol. 12, no. 4, 2006, pp. 205-209. https://doi.org/10.1007/BF02893413

Krušlin, Božo, Davor Tomas, Aida Cviko, Hrvoje Čupić, Ljubica Odak and Mladen Belicza. "Periacinar clefting and p63 immunostaining in prostatic intraepithelial neoplasia and prostatic carcinoma." Pathology Oncology Research 12, no. 4 (2006): 205-209. https://doi.org/10.1007/BF02893413

Krušlin, B., et al. (2006) 'Periacinar clefting and p63 immunostaining in prostatic intraepithelial neoplasia and prostatic carcinoma', Pathology Oncology Research, 12(4), pp. 205-209. doi: 10.1007/BF02893413

Krušlin B, Tomas D, Cviko A, Čupić H, Odak Lj, Belicza M. Periacinar clefting and p63 immunostaining in prostatic intraepithelial neoplasia and prostatic carcinoma. Pathology Oncology Research [Internet]. 2006 [cited 2024 May 06];12(4):205-209. doi: 10.1007/BF02893413

B. Krušlin, D. Tomas, A. Cviko, H. Čupić, Lj. Odak and M. Belicza, "Periacinar clefting and p63 immunostaining in prostatic intraepithelial neoplasia and prostatic carcinoma", Pathology Oncology Research, vol. 12, no. 4, pp. 205-209, 2006. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:971399. [Accessed: 06 May 2024]

Metadata
Title (english)Periacinar clefting and p63 immunostaining in prostatic intraepithelial neoplasia and prostatic carcinoma
AuthorBožo Krušlin
AuthorDavor Tomas
AuthorAida Cviko
AuthorHrvoje Čupić
AuthorLjubica Odak
AuthorMladen Belicza
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
The aim of the present study was to correlate the presence and extent of retraction clefting and the expression of p63 in neoplastic glands and glands with prostatic intraepithelial neoplasia (PIN) in needle core biopsies. We analyzed needle core biopsies from 28 patients with PIN and 41 patients with adenocarcinoma. Neoplastic glands and those with PIN were analyzed on high power field (400x) and classified in three groups according to the extent of clefting. Immunohistochemical staining was performed following Microwave Streptavidin ImmunoPeroxidase (MSIP) protocol on DAKO TechMate Horizon automated immunostainer. Periacinar retraction clefting was significantly more prominent in prostatic carcinoma compared to PIN (p<0.0001) and nonneoplastic glands (p<0.0001). There was no difference between normal glands and PIN regarding clefting (p=0.8064). p63 was positive around the whole circumference in 12 out of 28 cases with PIN, and discontinuously positive in remaining 16 PIN cases suggesting initial disruption of the basal cell layer. p63 immunostaining was also positive in all nonneoplastic glands, and negative in all carcinomas. We conclude that retraction clefting was associated with cancer and lack of basal cells, but not with PIN. The relationship between clefting and p63 immunostaining in prostatic cancer should be further analyzed.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titlePathology Oncology Research
Numberingvol. 12, no. 4, pp. 205-209
p-ISSN1219-4956
DOIhttps://doi.org/10.1007/BF02893413
URN:NBNurn:nbn:hr:105:971399
Publication2006
Document URLhttp://por.hu/2006/12/4/0205/0205a.pdf
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 11:34:42