prikaz prve stranice dokumenta Periacinar clefting and p63 immunostaining in prostatic intraepithelial neoplasia and prostatic carcinoma
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Periacinar clefting and p63 immunostaining in prostatic intraepithelial neoplasia and prostatic carcinoma
Pathology Oncology Research, 12 (2006), 4; 205-209. https://doi.org/10.1007/BF02893413
Krušlin, Božo; Tomas, Davor; Cviko, Aida; Čupić, Hrvoje; Odak, Ljubica; Belicza, Mladen

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Citirajte ovaj rad

Krušlin, B., Tomas, D., Cviko, A., Čupić, H., Odak, Lj. i Belicza, M. (2006). Periacinar clefting and p63 immunostaining in prostatic intraepithelial neoplasia and prostatic carcinoma. Pathology Oncology Research, 12. (4), 205-209. doi: 10.1007/BF02893413

Krušlin, Božo, et al. "Periacinar clefting and p63 immunostaining in prostatic intraepithelial neoplasia and prostatic carcinoma." Pathology Oncology Research, vol. 12, br. 4, 2006, str. 205-209. https://doi.org/10.1007/BF02893413

Krušlin, Božo, Davor Tomas, Aida Cviko, Hrvoje Čupić, Ljubica Odak i Mladen Belicza. "Periacinar clefting and p63 immunostaining in prostatic intraepithelial neoplasia and prostatic carcinoma." Pathology Oncology Research 12, br. 4 (2006): 205-209. https://doi.org/10.1007/BF02893413

Krušlin, B., et al. (2006) 'Periacinar clefting and p63 immunostaining in prostatic intraepithelial neoplasia and prostatic carcinoma', Pathology Oncology Research, 12(4), str. 205-209. doi: 10.1007/BF02893413

Krušlin B, Tomas D, Cviko A, Čupić H, Odak Lj, Belicza M. Periacinar clefting and p63 immunostaining in prostatic intraepithelial neoplasia and prostatic carcinoma. Pathology Oncology Research [Internet]. 2006. [pristupljeno 26.05.2024.];12(4):205-209. doi: 10.1007/BF02893413

B. Krušlin, D. Tomas, A. Cviko, H. Čupić, Lj. Odak i M. Belicza, "Periacinar clefting and p63 immunostaining in prostatic intraepithelial neoplasia and prostatic carcinoma", Pathology Oncology Research, vol. 12, br. 4, str. 205-209, 2006. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:971399. [Citirano: 26.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:971399
Podaci o radu
Naslov (engleski)Periacinar clefting and p63 immunostaining in prostatic intraepithelial neoplasia and prostatic carcinoma
AutorBožo Krušlin
AutorDavor Tomas
AutorAida Cviko
AutorHrvoje Čupić
AutorLjubica Odak
AutorMladen Belicza
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
The aim of the present study was to correlate the presence and extent of retraction clefting and the expression of p63 in neoplastic glands and glands with prostatic intraepithelial neoplasia (PIN) in needle core biopsies. We analyzed needle core biopsies from 28 patients with PIN and 41 patients with adenocarcinoma. Neoplastic glands and those with PIN were analyzed on high power field (400x) and classified in three groups according to the extent of clefting. Immunohistochemical staining was performed following Microwave Streptavidin ImmunoPeroxidase (MSIP) protocol on DAKO TechMate Horizon automated immunostainer. Periacinar retraction clefting was significantly more prominent in prostatic carcinoma compared to PIN (p<0.0001) and nonneoplastic glands (p<0.0001). There was no difference between normal glands and PIN regarding clefting (p=0.8064). p63 was positive around the whole circumference in 12 out of 28 cases with PIN, and discontinuously positive in remaining 16 PIN cases suggesting initial disruption of the basal cell layer. p63 immunostaining was also positive in all nonneoplastic glands, and negative in all carcinomas. We conclude that retraction clefting was associated with cancer and lack of basal cells, but not with PIN. The relationship between clefting and p63 immunostaining in prostatic cancer should be further analyzed.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaPathology Oncology Research
Brojčani podacivol. 12, br. 4, str. 205-209
p-ISSN1219-4956
DOIhttps://doi.org/10.1007/BF02893413
URN:NBNurn:nbn:hr:105:971399
Datum objave publikacije2006
URL dokumentahttp://por.hu/2006/12/4/0205/0205a.pdf
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 11:34:42