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Scientific paper - Original scientific paper
Central insulin resistance as a trigger for sporadic Alzheimer-like pathology: an experimental approach
Journal of Neural Transmission. Supplementum, 72 (2007); 217-33. https://doi.org/10.1007/978-3-211-73574-9_28
Šalković-Petrišić, Melita; Hoyer, Siegfried

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Šalković Petrišić, M. & Hoyer, S. (2007). Central insulin resistance as a trigger for sporadic Alzheimer-like pathology: an experimental approach. Journal of Neural Transmission. Supplementum, 72., 217-33. doi: 10.1007/978-3-211-73574-9_28

Šalković Petrišić, Melita and Siegfried Hoyer. "Central insulin resistance as a trigger for sporadic Alzheimer-like pathology: an experimental approach." Journal of Neural Transmission. Supplementum, vol. 72, 2007, pp. 217-33. https://doi.org/10.1007/978-3-211-73574-9_28

Šalković Petrišić, Melita and Siegfried Hoyer. "Central insulin resistance as a trigger for sporadic Alzheimer-like pathology: an experimental approach." Journal of Neural Transmission. Supplementum 72 (2007): 217-33. https://doi.org/10.1007/978-3-211-73574-9_28

Šalković Petrišić, M. and Hoyer, S. (2007) 'Central insulin resistance as a trigger for sporadic Alzheimer-like pathology: an experimental approach', Journal of Neural Transmission. Supplementum, 72, pp. 217-33. doi: 10.1007/978-3-211-73574-9_28

Šalković Petrišić M, Hoyer S. Central insulin resistance as a trigger for sporadic Alzheimer-like pathology: an experimental approach. Journal of Neural Transmission. Supplementum [Internet]. 2007 December 28 [cited 2024 November 22];72:217-33. doi: 10.1007/978-3-211-73574-9_28

M. Šalković Petrišić and S. Hoyer, "Central insulin resistance as a trigger for sporadic Alzheimer-like pathology: an experimental approach", Journal of Neural Transmission. Supplementum, vol. 72, pp. 217-33, December 2007. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:989050. [Accessed: 22 November 2024]

Metadata
Title (english)Central insulin resistance as a trigger for sporadic Alzheimer-like pathology: an experimental approach
AuthorMelita Šalković-Petrišić
AuthorSiegfried Hoyer
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
A growing body of evidence implicates impairments in brain insulin signaling in early sporadic Alzheimer disease (sAD) pathology. However, the most widely accepted hypothesis for AD aetiology stipulates that pathological aggregations of the amyloid beta (Abeta) peptide are the cause of all forms of Alzheimer's disease. Streptozotocin-intracerebroventricularly (STZ-icv) treated rats are proposed as a probable experimental model of sAD. The current work reviews evidence obtained from this model indicating that central STZ administration induces brain pathology and behavioural alterations resembling those in sAD patients. Recently, alterations of the brain insulin system resembling those in sAD have been found in the STZ-icv rat model and are associated with tau protein hyperphosphorylation and Abeta-like aggregations in meningeal vessels. In line with these findings the hypothesis has been proposed that insulin resistance in the brain might be the primary event which precedes the Abeta pathology in sAD.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleJournal of Neural Transmission. Supplementum
Numberingvol. 72, pp. 217-33
p-ISSN0303-6975
DOIhttps://doi.org/10.1007/978-3-211-73574-9_28
URN:NBNurn:nbn:hr:105:989050
Publication2007-12-28
Document URLhttps://doi.org/10.1007/978-3-211-73574-9_28
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 11:35:23