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Central insulin resistance as a trigger for sporadic Alzheimer-like pathology: an experimental approach
Journal of Neural Transmission. Supplementum, 72 (2007); 217-33. https://doi.org/10.1007/978-3-211-73574-9_28
Šalković-Petrišić, Melita; Hoyer, Siegfried

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Šalković Petrišić, M. i Hoyer, S. (2007). Central insulin resistance as a trigger for sporadic Alzheimer-like pathology: an experimental approach. Journal of Neural Transmission. Supplementum, 72., 217-33. doi: 10.1007/978-3-211-73574-9_28

Šalković Petrišić, Melita i Siegfried Hoyer. "Central insulin resistance as a trigger for sporadic Alzheimer-like pathology: an experimental approach." Journal of Neural Transmission. Supplementum, vol. 72, 2007, str. 217-33. https://doi.org/10.1007/978-3-211-73574-9_28

Šalković Petrišić, Melita i Siegfried Hoyer. "Central insulin resistance as a trigger for sporadic Alzheimer-like pathology: an experimental approach." Journal of Neural Transmission. Supplementum 72 (2007): 217-33. https://doi.org/10.1007/978-3-211-73574-9_28

Šalković Petrišić, M. i Hoyer, S. (2007) 'Central insulin resistance as a trigger for sporadic Alzheimer-like pathology: an experimental approach', Journal of Neural Transmission. Supplementum, 72, str. 217-33. doi: 10.1007/978-3-211-73574-9_28

Šalković Petrišić M, Hoyer S. Central insulin resistance as a trigger for sporadic Alzheimer-like pathology: an experimental approach. Journal of Neural Transmission. Supplementum [Internet]. 28.12.2007. [pristupljeno 22.11.2024.];72:217-33. doi: 10.1007/978-3-211-73574-9_28

M. Šalković Petrišić i S. Hoyer, "Central insulin resistance as a trigger for sporadic Alzheimer-like pathology: an experimental approach", Journal of Neural Transmission. Supplementum, vol. 72, str. 217-33, Prosinac 2007. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:989050. [Citirano: 22.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:989050
Podaci o radu
Naslov (engleski)Central insulin resistance as a trigger for sporadic Alzheimer-like pathology: an experimental approach
AutorMelita Šalković-Petrišić
AutorSiegfried Hoyer
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
A growing body of evidence implicates impairments in brain insulin signaling in early sporadic Alzheimer disease (sAD) pathology. However, the most widely accepted hypothesis for AD aetiology stipulates that pathological aggregations of the amyloid beta (Abeta) peptide are the cause of all forms of Alzheimer's disease. Streptozotocin-intracerebroventricularly (STZ-icv) treated rats are proposed as a probable experimental model of sAD. The current work reviews evidence obtained from this model indicating that central STZ administration induces brain pathology and behavioural alterations resembling those in sAD patients. Recently, alterations of the brain insulin system resembling those in sAD have been found in the STZ-icv rat model and are associated with tau protein hyperphosphorylation and Abeta-like aggregations in meningeal vessels. In line with these findings the hypothesis has been proposed that insulin resistance in the brain might be the primary event which precedes the Abeta pathology in sAD.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaJournal of Neural Transmission. Supplementum
Brojčani podacivol. 72, str. 217-33
p-ISSN0303-6975
DOIhttps://doi.org/10.1007/978-3-211-73574-9_28
URN:NBNurn:nbn:hr:105:989050
Datum objave publikacije2007-12-28
URL dokumentahttps://doi.org/10.1007/978-3-211-73574-9_28
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 11:35:23