prikaz prve stranice dokumenta The mouse gene Noto is expressed in the tail bud and essential for its morphogenesis
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Scientific paper - Original scientific paper
The mouse gene Noto is expressed in the tail bud and essential for its morphogenesis
Cells Tissues Organs, 192 (2010), 2; 85-92. https://doi.org/10.1159/000291015
Žižić Mitrečić, Marica; Mitrečić, Dinko; Pochet, Roland; Kostović-Knežević, Ljiljana; Gajović, Srećko

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Žižić Mitrečić, M., Mitrečić, D., Pochet, R., Kostović Knežević, Lj. & Gajović, S. (2010). The mouse gene Noto is expressed in the tail bud and essential for its morphogenesis. Cells Tissues Organs, 192. (2), 85-92. doi: 10.1159/000291015

Žižić Mitrečić, Marica, et al. "The mouse gene Noto is expressed in the tail bud and essential for its morphogenesis." Cells Tissues Organs, vol. 192, no. 2, 2010, pp. 85-92. https://doi.org/10.1159/000291015

Žižić Mitrečić, Marica, Dinko Mitrečić, Roland Pochet, Ljiljana Kostović Knežević and Srećko Gajović. "The mouse gene Noto is expressed in the tail bud and essential for its morphogenesis." Cells Tissues Organs 192, no. 2 (2010): 85-92. https://doi.org/10.1159/000291015

Žižić Mitrečić, M., et al. (2010) 'The mouse gene Noto is expressed in the tail bud and essential for its morphogenesis', Cells Tissues Organs, 192(2), pp. 85-92. doi: 10.1159/000291015

Žižić Mitrečić M, Mitrečić D, Pochet R, Kostović Knežević Lj, Gajović S. The mouse gene Noto is expressed in the tail bud and essential for its morphogenesis. Cells Tissues Organs [Internet]. 2010 February 27 [cited 2024 November 22];192(2):85-92. doi: 10.1159/000291015

M. Žižić Mitrečić, D. Mitrečić, R. Pochet, Lj. Kostović Knežević and S. Gajović, "The mouse gene Noto is expressed in the tail bud and essential for its morphogenesis", Cells Tissues Organs, vol. 192, no. 2, pp. 85-92, February 2010. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:519285. [Accessed: 22 November 2024]

Metadata
Title (english)The mouse gene Noto is expressed in the tail bud and essential for its morphogenesis
AuthorMarica Žižić Mitrečić
AuthorDinko Mitrečić
AuthorRoland Pochet
AuthorLjiljana Kostović-Knežević
AuthorSrećko Gajović
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
The mouse transcription factor Noto is expressed in the notochord and involved in its development. Noto mouse mutants, Noto(tc/tc)(truncate) and Noto(GFP/GFP) (Noto null mutant), exhibit a segmental lack of the notochord in the caudal part of the embryo and subsequent tail truncation in adult animals. In order to address the relationship between the tail bud (the undifferentiated mesenchymal cells in the tip of the embryo tail) and the caudal notochord, Noto(GFP/GFP), a loss- of-function mutant, was analyzed. Taking advantage of Noto(GFP/+) heterozygotes, we could track Noto-GFP-expressing cells from the tail bud over the tail cord to the caudal notochord, and confirm a morphological continuum from the tail bud mesenchyme to the caudal notochord. Loss of Noto affected tail bud morphogenesis: Noto-GFP-expressing cells were scattered in the tail bud mesenchyme. They segregated in the notochord-like structure within the medullary cord instead at the tail cord, which subsequently disappeared. In the tail cord, instead of the notochord, additional lumen of the tail gut was formed. These findings suggest that Noto is involved in both rearrangement and morphogenesis of the tail bud during notochord formation.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionSubmitted version
Journal titleCells Tissues Organs
Numberingvol. 192, no. 2, pp. 85-92
p-ISSN1422-6405
DOIhttps://doi.org/10.1159/000291015
URN:NBNurn:nbn:hr:105:519285
Publication2010-02-27
Document URLhttp://www.doi.org/10.1159/000291015
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 11:35:53