prikaz prve stranice dokumenta The mouse gene Noto is expressed in the tail bud and essential for its morphogenesis
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The mouse gene Noto is expressed in the tail bud and essential for its morphogenesis
Cells Tissues Organs, 192 (2010), 2; 85-92. https://doi.org/10.1159/000291015
Žižić Mitrečić, Marica; Mitrečić, Dinko; Pochet, Roland; Kostović-Knežević, Ljiljana; Gajović, Srećko

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Žižić Mitrečić, M., Mitrečić, D., Pochet, R., Kostović Knežević, Lj. i Gajović, S. (2010). The mouse gene Noto is expressed in the tail bud and essential for its morphogenesis. Cells Tissues Organs, 192. (2), 85-92. doi: 10.1159/000291015

Žižić Mitrečić, Marica, et al. "The mouse gene Noto is expressed in the tail bud and essential for its morphogenesis." Cells Tissues Organs, vol. 192, br. 2, 2010, str. 85-92. https://doi.org/10.1159/000291015

Žižić Mitrečić, Marica, Dinko Mitrečić, Roland Pochet, Ljiljana Kostović Knežević i Srećko Gajović. "The mouse gene Noto is expressed in the tail bud and essential for its morphogenesis." Cells Tissues Organs 192, br. 2 (2010): 85-92. https://doi.org/10.1159/000291015

Žižić Mitrečić, M., et al. (2010) 'The mouse gene Noto is expressed in the tail bud and essential for its morphogenesis', Cells Tissues Organs, 192(2), str. 85-92. doi: 10.1159/000291015

Žižić Mitrečić M, Mitrečić D, Pochet R, Kostović Knežević Lj, Gajović S. The mouse gene Noto is expressed in the tail bud and essential for its morphogenesis. Cells Tissues Organs [Internet]. 27.02.2010. [pristupljeno 29.04.2024.];192(2):85-92. doi: 10.1159/000291015

M. Žižić Mitrečić, D. Mitrečić, R. Pochet, Lj. Kostović Knežević i S. Gajović, "The mouse gene Noto is expressed in the tail bud and essential for its morphogenesis", Cells Tissues Organs, vol. 192, br. 2, str. 85-92, Veljača 2010. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:519285. [Citirano: 29.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:519285
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Naslov (engleski)The mouse gene Noto is expressed in the tail bud and essential for its morphogenesis
AutorMarica Žižić Mitrečić
AutorDinko Mitrečić
AutorRoland Pochet
AutorLjiljana Kostović-Knežević
AutorSrećko Gajović
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
The mouse transcription factor Noto is expressed in the notochord and involved in its development. Noto mouse mutants, Noto(tc/tc)(truncate) and Noto(GFP/GFP) (Noto null mutant), exhibit a segmental lack of the notochord in the caudal part of the embryo and subsequent tail truncation in adult animals. In order to address the relationship between the tail bud (the undifferentiated mesenchymal cells in the tip of the embryo tail) and the caudal notochord, Noto(GFP/GFP), a loss- of-function mutant, was analyzed. Taking advantage of Noto(GFP/+) heterozygotes, we could track Noto-GFP-expressing cells from the tail bud over the tail cord to the caudal notochord, and confirm a morphological continuum from the tail bud mesenchyme to the caudal notochord. Loss of Noto affected tail bud morphogenesis: Noto-GFP-expressing cells were scattered in the tail bud mesenchyme. They segregated in the notochord-like structure within the medullary cord instead at the tail cord, which subsequently disappeared. In the tail cord, instead of the notochord, additional lumen of the tail gut was formed. These findings suggest that Noto is involved in both rearrangement and morphogenesis of the tail bud during notochord formation.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeRukopis poslan na recenzijski postupak (preprint)
Naslov časopisaCells Tissues Organs
Brojčani podacivol. 192, br. 2, str. 85-92
p-ISSN1422-6405
DOIhttps://doi.org/10.1159/000291015
URN:NBNurn:nbn:hr:105:519285
Datum objave publikacije2010-02-27
URL dokumentahttp://www.doi.org/10.1159/000291015
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 11:35:53