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Scientific paper - Original scientific paper
Cytogenetics of multiple myeloma
Collegium Antropologicum, 34 (2010), 1; 41-44. urn:nbn:hr:105:444114
Lasan Trčić, Ružica; Kardum Skelin, Ika; Šušterčić, Dunja; Planinc-Peraica, Ana; Ajduković, Radmila; Hariš, Višnja; Kušec, Rajko; Begović, Davor

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Lasan Trčić, R., Kardum Skelin, I., Šušterčić, D., Planinc Peraica, A., Ajduković, R., Hariš, V. ... Begović, D. (2010). Cytogenetics of multiple myeloma . Collegium Antropologicum, 34. (1), 41-44. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:444114

Lasan Trčić, Ružica, et al. "Cytogenetics of multiple myeloma ." Collegium Antropologicum, vol. 34, no. 1, 2010, pp. 41-44. https://urn.nsk.hr/urn:nbn:hr:105:444114

Lasan Trčić, Ružica, Ika Kardum Skelin, Dunja Šušterčić, Ana Planinc Peraica, Radmila Ajduković, Višnja Hariš, Rajko Kušec and Davor Begović. "Cytogenetics of multiple myeloma ." Collegium Antropologicum 34, no. 1 (2010): 41-44. https://urn.nsk.hr/urn:nbn:hr:105:444114

Lasan Trčić, R., et al. (2010) 'Cytogenetics of multiple myeloma ', Collegium Antropologicum, 34(1), pp. 41-44. Available at: https://urn.nsk.hr/urn:nbn:hr:105:444114 (Accessed 22 November 2024)

Lasan Trčić R, Kardum Skelin I, Šušterčić D, Planinc Peraica A, Ajduković R, Hariš V, and sur.. Cytogenetics of multiple myeloma . Collegium Antropologicum [Internet]. 2010 March [cited 2024 November 22];34(1):41-44. Available at: https://urn.nsk.hr/urn:nbn:hr:105:444114

R. Lasan Trčić, et al., "Cytogenetics of multiple myeloma ", Collegium Antropologicum, vol. 34, no. 1, pp. 41-44, March 2010. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:444114. [Accessed: 22 November 2024]

Metadata
Title (english)Cytogenetics of multiple myeloma
Title (croatian)Citogenetski rezultati 24 slučajeva multiplog mieloma
AuthorRužica Lasan Trčić
AuthorIka Kardum Skelin
AuthorDunja Šušterčić
AuthorAna Planinc-Peraica
AuthorRadmila Ajduković
AuthorVišnja Hariš
AuthorRajko Kušec
AuthorDavor Begović
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Great studies of multiple myeloma (MM) strongly suggested that specific chromosomal changes are of prognostic significance in patients with MM1. We have performed cytogenetic analysis and recently fluorescent in situ hybridization (FISH) on 43 cases of MM. Clonal chromosomal changes were present in 24 (56%) cases. Hyperdiploid karyotype was found in 12 (50%) cases, hypodiploid in 8 (33%) cases, and 4 (17%) cases had a pseudodiploid karyotype. The most common numerical abnormalities were gains of whole chromosomes 15, 11, 3 and 6. Whole chromosome losses were also frequent involving chromosomes X, 13, 14, and 8. Most cases showed also structural rearrangements 71% (n=17): del(1p), dup(1q), del(5q), del(13q), del(17p) and t(11;14)(q13;q32) (n=4, 17%). Chromosome –13/13q deletion was found in 42% (n=10) cases; complete loss of 13 was observed in 67% (n=7) cases, whereas 33% (n=3) had interstitial deletions. In the majority of the cases there was a mixture of abnormal and normal metaphases.
Abstract (croatian)
Velika ispitivanja multiplog mieloma (MM) naglašavaju da su određene kromosomske promjene od indikativnog značaja za pacijente s MM. Izvršili smo citogenetičke analize, a i u novije vrijeme i florescentnu in situ hibridizaciju (FISH) na 43 slučaja sa MM. Klonske kromosomske promjene bile su prisutne kod 24 (56%) slučaja. Hiperdiploidni kariotip je nađen kod 12 (50%) slučaja, hipodiploidni kod 8 (33%) slučaja, i 4 (17%) slučaja imalo je pseudodiploidni kariotip. Najčešće brojčane nepravilnosti bile su suvišci kromosoma 15, 11, 3 i 6. Manjak čitavih kromosoma bili su česti kod kromosoma X, 13, 14, i 8. Većina slučajeva također je pokazala strukturalne preuredbe 71% (n=17): del(1p), dup(1q), del(5q), del(13q), del(17p) and t (11;14)(q13;q32) (n=4,17%). Kromosom – 13/13q delecija nađen je u 42% (n=10) slučaja, potpuni gubitak kromosoma 13 uočen je kod 67% (n=7) slučaja, dok je 33% (n=3) bilo s intersticijskom delecijom. U većini slučajeva bile su uz abnormalne prisutne i normalne metafaze.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium Antropologicum
Numberingvol. 34, no. 1, pp. 41-44
p-ISSN0350-6134
URN:NBNurn:nbn:hr:105:444114
Publication2010-03
Document URLhttps://hrcak.srce.hr/51239
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 11:44:13