prikaz prve stranice dokumenta FOXP1 expression in monoclonal gammopathy of undetermined significance and multiple myeloma
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Scientific paper - Original scientific paper
FOXP1 expression in monoclonal gammopathy of undetermined significance and multiple myeloma
Pathology International, 59 (2009), 5; 354-358. https://doi.org/10.1111/j.1440-1827.2009.02377.x
Korać, Petra; Peran, Ivana; Škrtić, Anita; Ajduković, Radmila; Radić Krišto, Delfa; Dominis, Mara

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Korać, P., Peran, I., Škrtić, A., Ajduković, R., Radić Krišto, D. & Dominis, M. (2009). FOXP1 expression in monoclonal gammopathy of undetermined significance and multiple myeloma. Pathology International, 59. (5), 354-358. doi: 10.1111/j.1440-1827.2009.02377.x

Korać, Petra, et al. "FOXP1 expression in monoclonal gammopathy of undetermined significance and multiple myeloma." Pathology International, vol. 59, no. 5, 2009, pp. 354-358. https://doi.org/10.1111/j.1440-1827.2009.02377.x

Korać, Petra, Ivana Peran, Anita Škrtić, Radmila Ajduković, Delfa Radić Krišto and Mara Dominis. "FOXP1 expression in monoclonal gammopathy of undetermined significance and multiple myeloma." Pathology International 59, no. 5 (2009): 354-358. https://doi.org/10.1111/j.1440-1827.2009.02377.x

Korać, P., et al. (2009) 'FOXP1 expression in monoclonal gammopathy of undetermined significance and multiple myeloma', Pathology International, 59(5), pp. 354-358. doi: 10.1111/j.1440-1827.2009.02377.x

Korać P, Peran I, Škrtić A, Ajduković R, Radić Krišto D, Dominis M. FOXP1 expression in monoclonal gammopathy of undetermined significance and multiple myeloma. Pathology International [Internet]. 2009 May [cited 2024 April 28];59(5):354-358. doi: 10.1111/j.1440-1827.2009.02377.x

P. Korać, I. Peran, A. Škrtić, R. Ajduković, D. Radić Krišto and M. Dominis, "FOXP1 expression in monoclonal gammopathy of undetermined significance and multiple myeloma", Pathology International, vol. 59, no. 5, pp. 354-358, May 2009. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:575436. [Accessed: 28 April 2024]

Metadata
Title (english)FOXP1 expression in monoclonal gammopathy of undetermined significance and multiple myeloma
AuthorPetra Korać
AuthorIvana Peran
AuthorAnita Škrtić
AuthorRadmila Ajduković
AuthorDelfa Radić Krišto
AuthorMara Dominis
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Multiple myeloma (MM) is a clonal disorder of terminally differentiated B cells. In some cases the premalignant state is monoclonal gammopathy of undetermined significance (MGUS). Neoplastic plasma cells in both entities carry multiple and complex chromosomal abnormalities that make understanding of the disease development difficult. New insight into malignant mechanisms that underlie multiple myeloma may come from forkhead box P1 transcription factor (FOXP1) analysis in neoplastic plasma cells. FOXP1 is known to be important for B-cell maturation and differentiation and could play a significant role in plasma cell tumors. The purpose of the present study was therefore to analyze FOXP1 protein presence and FOXP1 gene abnormalities in 13 cases of MGUS and 60 cases of MM. It was found that FOXP1 protein was expressed in neoplastic plasma cells, unlike in their normal counterparts, and that additional FOXP1 gene copies could be found in both MGUS and MM. Based on FOXP1 presence in MM and its role in diffuse large B-cell lymphoma and extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue, FOXP1 might play an important role in plasma cell neoplasm.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titlePathology International
Numberingvol. 59, no. 5, pp. 354-358
p-ISSN1320-5463
DOIhttps://doi.org/10.1111/j.1440-1827.2009.02377.x
URN:NBNurn:nbn:hr:105:575436
Publication2009-05
Document URLhttps://doi.org/10.1111/j.1440-1827.2009.02377.x
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 11:51:15