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FOXP1 expression in monoclonal gammopathy of undetermined significance and multiple myeloma
Pathology International, 59 (2009), 5; 354-358. https://doi.org/10.1111/j.1440-1827.2009.02377.x
Korać, Petra; Peran, Ivana; Škrtić, Anita; Ajduković, Radmila; Radić Krišto, Delfa; Dominis, Mara

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Korać, P., Peran, I., Škrtić, A., Ajduković, R., Radić Krišto, D. i Dominis, M. (2009). FOXP1 expression in monoclonal gammopathy of undetermined significance and multiple myeloma. Pathology International, 59. (5), 354-358. doi: 10.1111/j.1440-1827.2009.02377.x

Korać, Petra, et al. "FOXP1 expression in monoclonal gammopathy of undetermined significance and multiple myeloma." Pathology International, vol. 59, br. 5, 2009, str. 354-358. https://doi.org/10.1111/j.1440-1827.2009.02377.x

Korać, Petra, Ivana Peran, Anita Škrtić, Radmila Ajduković, Delfa Radić Krišto i Mara Dominis. "FOXP1 expression in monoclonal gammopathy of undetermined significance and multiple myeloma." Pathology International 59, br. 5 (2009): 354-358. https://doi.org/10.1111/j.1440-1827.2009.02377.x

Korać, P., et al. (2009) 'FOXP1 expression in monoclonal gammopathy of undetermined significance and multiple myeloma', Pathology International, 59(5), str. 354-358. doi: 10.1111/j.1440-1827.2009.02377.x

Korać P, Peran I, Škrtić A, Ajduković R, Radić Krišto D, Dominis M. FOXP1 expression in monoclonal gammopathy of undetermined significance and multiple myeloma. Pathology International [Internet]. 05.2009. [pristupljeno 27.12.2024.];59(5):354-358. doi: 10.1111/j.1440-1827.2009.02377.x

P. Korać, I. Peran, A. Škrtić, R. Ajduković, D. Radić Krišto i M. Dominis, "FOXP1 expression in monoclonal gammopathy of undetermined significance and multiple myeloma", Pathology International, vol. 59, br. 5, str. 354-358, Svibanj 2009. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:575436. [Citirano: 27.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:575436
Podaci o radu
Naslov (engleski)FOXP1 expression in monoclonal gammopathy of undetermined significance and multiple myeloma
AutorPetra Korać
AutorIvana Peran
AutorAnita Škrtić
AutorRadmila Ajduković
AutorDelfa Radić Krišto
AutorMara Dominis
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Multiple myeloma (MM) is a clonal disorder of terminally differentiated B cells. In some cases the premalignant state is monoclonal gammopathy of undetermined significance (MGUS). Neoplastic plasma cells in both entities carry multiple and complex chromosomal abnormalities that make understanding of the disease development difficult. New insight into malignant mechanisms that underlie multiple myeloma may come from forkhead box P1 transcription factor (FOXP1) analysis in neoplastic plasma cells. FOXP1 is known to be important for B-cell maturation and differentiation and could play a significant role in plasma cell tumors. The purpose of the present study was therefore to analyze FOXP1 protein presence and FOXP1 gene abnormalities in 13 cases of MGUS and 60 cases of MM. It was found that FOXP1 protein was expressed in neoplastic plasma cells, unlike in their normal counterparts, and that additional FOXP1 gene copies could be found in both MGUS and MM. Based on FOXP1 presence in MM and its role in diffuse large B-cell lymphoma and extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue, FOXP1 might play an important role in plasma cell neoplasm.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaPathology International
Brojčani podacivol. 59, br. 5, str. 354-358
p-ISSN1320-5463
DOIhttps://doi.org/10.1111/j.1440-1827.2009.02377.x
URN:NBNurn:nbn:hr:105:575436
Datum objave publikacije2009-05
URL dokumentahttps://doi.org/10.1111/j.1440-1827.2009.02377.x
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 11:51:15