prikaz prve stranice dokumenta Treatment of chronic hepatitis C in Croatian war veterans: experiences from Croatian reference center for viral hepatitis
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Scientific paper - Original scientific paper
Treatment of chronic hepatitis C in Croatian war veterans: experiences from Croatian reference center for viral hepatitis
Croatian Medical Journal, 52 (2011), 1; 35-40. https://doi.org/10.3325/cmj.2011.52.35
Papić, Neven; Židovec Lepej, Snježana; Kurelac, Ivan; Čajić, Vjeran; Budimir, Jelena; Dušek, Davorka; Vince, Adriana

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Papić, N., Židovec Lepej, S., Kurelac, I., Čajić, V., Budimir, J., Dušek, D. & Vince, A. (2011). Treatment of chronic hepatitis C in Croatian war veterans: experiences from Croatian reference center for viral hepatitis. Croatian Medical Journal, 52. (1), 35-40. doi: 10.3325/cmj.2011.52.35

Papić, Neven, et al. "Treatment of chronic hepatitis C in Croatian war veterans: experiences from Croatian reference center for viral hepatitis." Croatian Medical Journal, vol. 52, no. 1, 2011, pp. 35-40. https://doi.org/10.3325/cmj.2011.52.35

Papić, Neven, Snježana Židovec Lepej, Ivan Kurelac, Vjeran Čajić, Jelena Budimir, Davorka Dušek and Adriana Vince. "Treatment of chronic hepatitis C in Croatian war veterans: experiences from Croatian reference center for viral hepatitis." Croatian Medical Journal 52, no. 1 (2011): 35-40. https://doi.org/10.3325/cmj.2011.52.35

Papić, N., et al. (2011) 'Treatment of chronic hepatitis C in Croatian war veterans: experiences from Croatian reference center for viral hepatitis', Croatian Medical Journal, 52(1), pp. 35-40. doi: 10.3325/cmj.2011.52.35

Papić N, Židovec Lepej S, Kurelac I, Čajić V, Budimir J, Dušek D, and sur.. Treatment of chronic hepatitis C in Croatian war veterans: experiences from Croatian reference center for viral hepatitis. Croatian Medical Journal [Internet]. 2011 February 15 [cited 2024 November 26];52(1):35-40. doi: 10.3325/cmj.2011.52.35

N. Papić, et al., "Treatment of chronic hepatitis C in Croatian war veterans: experiences from Croatian reference center for viral hepatitis", Croatian Medical Journal, vol. 52, no. 1, pp. 35-40, February 2011. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:039568. [Accessed: 26 November 2024]

Metadata
Title (english)Treatment of chronic hepatitis C in Croatian war veterans: experiences from Croatian reference center for viral hepatitis
AuthorNeven Papić
AuthorSnježana Židovec Lepej
AuthorIvan Kurelac
AuthorVjeran Čajić
AuthorJelena Budimir
AuthorDavorka Dušek
AuthorAdriana Vince
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Aim. To examine the risk factors, comorbidity, severity of liver disease, treatment course, and outcome in Croatian war veterans with chronic hepatitis C, especially those suffering from posttraumatic stress disorder (PTSD). ----- Methods. We collected medical records of 170 adult men diagnosed with chronic hepatitis C who started treatment with a combination of pegylated interferon-alpha and ribavirin between January 2003 and June 2009 at the Croatian Reference Centre for Viral Hepatitis. ----- Results. Participants' mean age was 43±9 years. Among 170 participants, there were 37 war veterans (22%). The main risk factor in veteran patients were operative procedures with transfusions (46% vs 5% in non-veterans; P<0.001) and in non-veteran patients intravenous drug use (42.1% vs 13%; P<0.001). The average duration of infection was longer in war veterans (14.5±3.4 vs 12.2±7.2 years; P=0.020). The percentage of PTSD comorbidity in the whole group was 11% (18/170) and in the war veterans group 49% (18/37). The prevalence of sustained virological response in patients with PTSD was 50% and in patients without PTSD 56%. Treatment reduction in patients with PTSD (33%) was higher than in patients without PTSD (12%; P=0.030). ----- Conclusion. Croatian war veterans are a group with high risk of chronic hepatitis C infection because many of them were wounded during the Croatian War 1991-1995. Considerations about PTSD as a contraindication for interferon treatment are unjustified. If treated, patients with PTSD have an equal chance of achieving sustained virological response as patients without PTSD.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCroatian Medical Journal
Numberingvol. 52, no. 1, pp. 35-40
p-ISSN0353-9504
DOIhttps://doi.org/10.3325/cmj.2011.52.35
URN:NBNurn:nbn:hr:105:039568
Publication2011-02-15
Document URLhttp://www.cmj.hr/2011/52/1/21328718.htm
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 11:59:40