prikaz prve stranice dokumenta Exploratory Study of Gastrointestinal Redox Biomarkers in the Presymptomatic and Symptomatic Tg2576 Mouse Model of Familial Alzheimer's Disease: Phenotypic Correlates and Effects of Chronic Oral d-Galactose
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Scientific paper - Original scientific paper
Exploratory Study of Gastrointestinal Redox Biomarkers in the Presymptomatic and Symptomatic Tg2576 Mouse Model of Familial Alzheimer's Disease: Phenotypic Correlates and Effects of Chronic Oral d-Galactose
ACS Chemical Neuroscience, 14 (2023), 22; 4013-4025. https://doi.org/10.1021/acschemneuro.3c00495
Homolak, Jan; Babić Perhoč, Ana; Knezović, Ana; Osmanović Barilar, Jelena; Virag, Davor; Šalković-Petrišić, Melita

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Homolak, J., Babić Perhoč, A., Knezović, A., Osmanović Barilar, J., Virag, D. & Šalković Petrišić, M. (2023). Exploratory Study of Gastrointestinal Redox Biomarkers in the Presymptomatic and Symptomatic Tg2576 Mouse Model of Familial Alzheimer's Disease: Phenotypic Correlates and Effects of Chronic Oral d-Galactose. ACS Chemical Neuroscience, 14. (22), 4013-4025. doi: 10.1021/acschemneuro.3c00495

Homolak, Jan, et al. "Exploratory Study of Gastrointestinal Redox Biomarkers in the Presymptomatic and Symptomatic Tg2576 Mouse Model of Familial Alzheimer's Disease: Phenotypic Correlates and Effects of Chronic Oral d-Galactose." ACS Chemical Neuroscience, vol. 14, no. 22, 2023, pp. 4013-4025. https://doi.org/10.1021/acschemneuro.3c00495

Homolak, Jan, Ana Babić Perhoč, Ana Knezović, Jelena Osmanović Barilar, Davor Virag and Melita Šalković Petrišić. "Exploratory Study of Gastrointestinal Redox Biomarkers in the Presymptomatic and Symptomatic Tg2576 Mouse Model of Familial Alzheimer's Disease: Phenotypic Correlates and Effects of Chronic Oral d-Galactose." ACS Chemical Neuroscience 14, no. 22 (2023): 4013-4025. https://doi.org/10.1021/acschemneuro.3c00495

Homolak, J., et al. (2023) 'Exploratory Study of Gastrointestinal Redox Biomarkers in the Presymptomatic and Symptomatic Tg2576 Mouse Model of Familial Alzheimer's Disease: Phenotypic Correlates and Effects of Chronic Oral d-Galactose', ACS Chemical Neuroscience, 14(22), pp. 4013-4025. doi: 10.1021/acschemneuro.3c00495

Homolak J, Babić Perhoč A, Knezović A, Osmanović Barilar J, Virag D, Šalković Petrišić M. Exploratory Study of Gastrointestinal Redox Biomarkers in the Presymptomatic and Symptomatic Tg2576 Mouse Model of Familial Alzheimer's Disease: Phenotypic Correlates and Effects of Chronic Oral d-Galactose. ACS Chemical Neuroscience [Internet]. 2023 November 15 [cited 2024 November 22];14(22):4013-4025. doi: 10.1021/acschemneuro.3c00495

J. Homolak, A. Babić Perhoč, A. Knezović, J. Osmanović Barilar, D. Virag and M. Šalković Petrišić, "Exploratory Study of Gastrointestinal Redox Biomarkers in the Presymptomatic and Symptomatic Tg2576 Mouse Model of Familial Alzheimer's Disease: Phenotypic Correlates and Effects of Chronic Oral d-Galactose", ACS Chemical Neuroscience, vol. 14, no. 22, pp. 4013-4025, November 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:023423. [Accessed: 22 November 2024]

Metadata
Title (english)Exploratory Study of Gastrointestinal Redox Biomarkers in the Presymptomatic and Symptomatic Tg2576 Mouse Model of Familial Alzheimer's Disease: Phenotypic Correlates and Effects of Chronic Oral d-Galactose
AuthorJan Homolak
AuthorAna Babić Perhoč
AuthorAna Knezović
AuthorJelena Osmanović Barilar
AuthorDavor Virag
AuthorMelita Šalković-Petrišić
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Pharmacology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Pharmacology
Abstract (english)
The gut might play an important role in the etiopathogenesis of Alzheimer's disease (AD) as gastrointestinal alterations often precede the development of neuropathological changes in the brain and correlate with disease progression in animal models. The gut has an immense capacity to generate free radicals whose role in the etiopathogenesis of AD is well-known; however, it remains to be clarified whether gastrointestinal redox homeostasis is associated with the development of AD. The aim was to (i) examine gastrointestinal redox homeostasis in the presymptomatic and symptomatic Tg2576 mouse model of AD; (ii) investigate the effects of oral d-galactose previously shown to alleviate cognitive deficits and metabolic changes in animal models of AD and reduce gastrointestinal oxidative stress; and (iii) investigate the association between gastrointestinal redox biomarkers and behavioral alterations in Tg2576 mice. In the presymptomatic stage, Tg2576 mice displayed an increased gastrointestinal electrophilic tone, characterized by higher lipid peroxidation and elevated Mn/Fe-SOD activity. In the symptomatic stage, these alterations are rectified, but the total antioxidant capacity is decreased. Chronic oral d-galactose increased the antioxidant capacity and reduced lipid peroxidation in the Tg2576 but had the opposite effects in the wild-type animals. The total antioxidant capacity of the gastrointestinal tract was associated with greater spatial memory. Gut redox homeostasis might be involved in the development and progression of AD pathophysiology and should be further explored in this context.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleACS Chemical Neuroscience
Numberingvol. 14, no. 22, pp. 4013-4025
p-ISSN1948-7193
e-ISSN1948-7193
DOIhttps://doi.org/10.1021/acschemneuro.3c00495
URN:NBNurn:nbn:hr:105:023423
Publication2023-11-15
Document URLhttps://pubs.acs.org/doi/10.1021/acschemneuro.3c00495
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-05-06 08:26:05