prikaz prve stranice dokumenta Exploratory Study of Gastrointestinal Redox Biomarkers in the Presymptomatic and Symptomatic Tg2576 Mouse Model of Familial Alzheimer's Disease: Phenotypic Correlates and Effects of Chronic Oral d-Galactose
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Exploratory Study of Gastrointestinal Redox Biomarkers in the Presymptomatic and Symptomatic Tg2576 Mouse Model of Familial Alzheimer's Disease: Phenotypic Correlates and Effects of Chronic Oral d-Galactose
ACS Chemical Neuroscience, 14 (2023), 22; 4013-4025. https://doi.org/10.1021/acschemneuro.3c00495
Homolak, Jan; Babić Perhoč, Ana; Knezović, Ana; Osmanović Barilar, Jelena; Virag, Davor; Šalković-Petrišić, Melita

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Homolak, J., Babić Perhoč, A., Knezović, A., Osmanović Barilar, J., Virag, D. i Šalković Petrišić, M. (2023). Exploratory Study of Gastrointestinal Redox Biomarkers in the Presymptomatic and Symptomatic Tg2576 Mouse Model of Familial Alzheimer's Disease: Phenotypic Correlates and Effects of Chronic Oral d-Galactose. ACS Chemical Neuroscience, 14. (22), 4013-4025. doi: 10.1021/acschemneuro.3c00495

Homolak, Jan, et al. "Exploratory Study of Gastrointestinal Redox Biomarkers in the Presymptomatic and Symptomatic Tg2576 Mouse Model of Familial Alzheimer's Disease: Phenotypic Correlates and Effects of Chronic Oral d-Galactose." ACS Chemical Neuroscience, vol. 14, br. 22, 2023, str. 4013-4025. https://doi.org/10.1021/acschemneuro.3c00495

Homolak, Jan, Ana Babić Perhoč, Ana Knezović, Jelena Osmanović Barilar, Davor Virag i Melita Šalković Petrišić. "Exploratory Study of Gastrointestinal Redox Biomarkers in the Presymptomatic and Symptomatic Tg2576 Mouse Model of Familial Alzheimer's Disease: Phenotypic Correlates and Effects of Chronic Oral d-Galactose." ACS Chemical Neuroscience 14, br. 22 (2023): 4013-4025. https://doi.org/10.1021/acschemneuro.3c00495

Homolak, J., et al. (2023) 'Exploratory Study of Gastrointestinal Redox Biomarkers in the Presymptomatic and Symptomatic Tg2576 Mouse Model of Familial Alzheimer's Disease: Phenotypic Correlates and Effects of Chronic Oral d-Galactose', ACS Chemical Neuroscience, 14(22), str. 4013-4025. doi: 10.1021/acschemneuro.3c00495

Homolak J, Babić Perhoč A, Knezović A, Osmanović Barilar J, Virag D, Šalković Petrišić M. Exploratory Study of Gastrointestinal Redox Biomarkers in the Presymptomatic and Symptomatic Tg2576 Mouse Model of Familial Alzheimer's Disease: Phenotypic Correlates and Effects of Chronic Oral d-Galactose. ACS Chemical Neuroscience [Internet]. 15.11.2023. [pristupljeno 29.12.2024.];14(22):4013-4025. doi: 10.1021/acschemneuro.3c00495

J. Homolak, A. Babić Perhoč, A. Knezović, J. Osmanović Barilar, D. Virag i M. Šalković Petrišić, "Exploratory Study of Gastrointestinal Redox Biomarkers in the Presymptomatic and Symptomatic Tg2576 Mouse Model of Familial Alzheimer's Disease: Phenotypic Correlates and Effects of Chronic Oral d-Galactose", ACS Chemical Neuroscience, vol. 14, br. 22, str. 4013-4025, Studeni 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:023423. [Citirano: 29.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:023423
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Naslov (engleski)Exploratory Study of Gastrointestinal Redox Biomarkers in the Presymptomatic and Symptomatic Tg2576 Mouse Model of Familial Alzheimer's Disease: Phenotypic Correlates and Effects of Chronic Oral d-Galactose
AutorJan Homolak
AutorAna Babić Perhoč
AutorAna Knezović
AutorJelena Osmanović Barilar
AutorDavor Virag
AutorMelita Šalković-Petrišić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA TEMELJNU I KLINIČKU FARMAKOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Farmakologija
Sažetak (engleski)
The gut might play an important role in the etiopathogenesis of Alzheimer's disease (AD) as gastrointestinal alterations often precede the development of neuropathological changes in the brain and correlate with disease progression in animal models. The gut has an immense capacity to generate free radicals whose role in the etiopathogenesis of AD is well-known; however, it remains to be clarified whether gastrointestinal redox homeostasis is associated with the development of AD. The aim was to (i) examine gastrointestinal redox homeostasis in the presymptomatic and symptomatic Tg2576 mouse model of AD; (ii) investigate the effects of oral d-galactose previously shown to alleviate cognitive deficits and metabolic changes in animal models of AD and reduce gastrointestinal oxidative stress; and (iii) investigate the association between gastrointestinal redox biomarkers and behavioral alterations in Tg2576 mice. In the presymptomatic stage, Tg2576 mice displayed an increased gastrointestinal electrophilic tone, characterized by higher lipid peroxidation and elevated Mn/Fe-SOD activity. In the symptomatic stage, these alterations are rectified, but the total antioxidant capacity is decreased. Chronic oral d-galactose increased the antioxidant capacity and reduced lipid peroxidation in the Tg2576 but had the opposite effects in the wild-type animals. The total antioxidant capacity of the gastrointestinal tract was associated with greater spatial memory. Gut redox homeostasis might be involved in the development and progression of AD pathophysiology and should be further explored in this context.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaACS Chemical Neuroscience
Brojčani podacivol. 14, br. 22, str. 4013-4025
p-ISSN1948-7193
e-ISSN1948-7193
DOIhttps://doi.org/10.1021/acschemneuro.3c00495
URN:NBNurn:nbn:hr:105:023423
Datum objave publikacije2023-11-15
URL dokumentahttps://pubs.acs.org/doi/10.1021/acschemneuro.3c00495
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-05-06 08:26:05