prikaz prve stranice dokumenta Reactive oxygen species within the vaginal space: An additional promoter of cervical intraepithelial neoplasia and uterine cervical cancer development?
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Scientific paper - Original scientific paper
Reactive oxygen species within the vaginal space: An additional promoter of cervical intraepithelial neoplasia and uterine cervical cancer development?
Open Medicine, 18 (2023), 1; 20230826. https://doi.org/10.1515/med-2023-0826
Despot, Albert; Fureš, Rajko; Despot, Ana-Marija; Mikuš, Mislav; Zlopaša, Gordan; D’Amato, Antonio; Chiantera, Vito; Serra, Pietro; Etrusco, Andrea; Laganà, Antonio Simone

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Despot, A., Fureš, R., Despot, A. M., Mikuš, M., Zlopaša, G., D’Amato, A. ... Laganà, A. S. (2023). Reactive oxygen species within the vaginal space: An additional promoter of cervical intraepithelial neoplasia and uterine cervical cancer development?. Open Medicine, 18. (1). doi: 10.1515/med-2023-0826

Despot, Albert, et al. "Reactive oxygen species within the vaginal space: An additional promoter of cervical intraepithelial neoplasia and uterine cervical cancer development?." Open Medicine, vol. 18, no. 1, 2023. https://doi.org/10.1515/med-2023-0826

Despot, Albert, Rajko Fureš, Ana Marija Despot, Mislav Mikuš, Gordan Zlopaša, Antonio D’Amato, Vito Chiantera, Pietro Serra, Andrea Etrusco and Antonio Simone Laganà. "Reactive oxygen species within the vaginal space: An additional promoter of cervical intraepithelial neoplasia and uterine cervical cancer development?." Open Medicine 18, no. 1 (2023). https://doi.org/10.1515/med-2023-0826

Despot, A., et al. (2023) 'Reactive oxygen species within the vaginal space: An additional promoter of cervical intraepithelial neoplasia and uterine cervical cancer development?', Open Medicine, 18(1). doi: 10.1515/med-2023-0826

Despot A, Fureš R, Despot AM, Mikuš M, Zlopaša G, D’Amato A, and sur.. Reactive oxygen species within the vaginal space: An additional promoter of cervical intraepithelial neoplasia and uterine cervical cancer development?. Open Medicine [Internet]. 2023 October 21 [cited 2024 October 06];18(1). doi: 10.1515/med-2023-0826

A. Despot, et al., "Reactive oxygen species within the vaginal space: An additional promoter of cervical intraepithelial neoplasia and uterine cervical cancer development?", Open Medicine, vol. 18, no. 1, October 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:359370. [Accessed: 06 October 2024]

Metadata
Title (english)Reactive oxygen species within the vaginal space: An additional promoter of cervical intraepithelial neoplasia and uterine cervical cancer development?
AuthorAlbert Despot
AuthorRajko Fureš
AuthorAna-Marija Despot
AuthorMislav Mikuš
AuthorGordan Zlopaša
AuthorAntonio D’Amato
AuthorVito Chiantera
AuthorPietro Serra
AuthorAndrea Etrusco
AuthorAntonio Simone Laganà
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Gynecology and Obstetrics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Gynecology and Obstetrics
Abstract (english)
Uterine cervical intraepithelial abnormalities and cancer development may also depend upon biological problems that arise as a result of complex molecular disturbances within the vaginal space, in addition to the widely known causative effect of human papillomavirus (HPV) infection. Chronic oxidative stress is a consequence of oxygen reduction in the vaginal space. Reactive oxygen species (ROS) and free radicals are yet unrecognizable causative agents and are probably very important factors for cervical intraepithelial neoplasia (CIN) and cancer development. The intermediate compounds of oxygen reduction on these metabolic pathways are superoxide anion(O2-), hydrogen peroxide (H2O2), hydroxide ions (OH-), and hydroxyl radical (HO˙). Considering these points, the aim of this work was to summarize how these compounds can damage all molecules, including DNA, of vulnerable metaplastic cervical epithelium. Finally, in some women with a poor immune defense system, ROS alone or accompanied by a high-risk HPV type may promote all levels of CIN and cancer development.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleOpen Medicine
Numberingvol. 18, no. 1, 20230826
e-ISSN2391-5463
DOIhttps://doi.org/10.1515/med-2023-0826
URN:NBNurn:nbn:hr:105:359370
Publication2023-10-21
Document URLhttps://www.degruyter.com/document/doi/10.1515/med-2023-0826/html
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-05-17 07:39:48