prikaz prve stranice dokumenta Detection of Bhanja Bandavirus in Patients with Neuroinvasive Disease of Unknown Etiology in Croatia
  Download
PDF 1.23 MB
Scientific paper - Original scientific paper
Detection of Bhanja Bandavirus in Patients with Neuroinvasive Disease of Unknown Etiology in Croatia
Microorganisms, 11 (2023), 9; 2155. https://doi.org/10.3390/microorganisms11092155
Vilibić-Čavlek, Tatjana; Stevanović, Vladimir; Krčmar, Stjepan; Savić, Vladimir; Kovač, Snježana; Bogdanić, Maja; Maurić Maljković, Maja; Sabadi, Dario; Santini, Marija; Potočnik-Hunjadi, Tanja; Al-Mufleh, Mahmoud; Barbić, Ljubo

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Vilibić Čavlek, T., Stevanović, V., Krčmar, S., Savić, V., Kovač, S., Bogdanić, M. ... Barbić, Lj. (2023). Detection of Bhanja Bandavirus in Patients with Neuroinvasive Disease of Unknown Etiology in Croatia. Microorganisms, 11. (9). doi: 10.3390/microorganisms11092155

Vilibić Čavlek, Tatjana, et al. "Detection of Bhanja Bandavirus in Patients with Neuroinvasive Disease of Unknown Etiology in Croatia." Microorganisms, vol. 11, no. 9, 2023. https://doi.org/10.3390/microorganisms11092155

Vilibić Čavlek, Tatjana, Vladimir Stevanović, Stjepan Krčmar, Vladimir Savić, Snježana Kovač, Maja Bogdanić, Maja Maurić Maljković, et al. "Detection of Bhanja Bandavirus in Patients with Neuroinvasive Disease of Unknown Etiology in Croatia." Microorganisms 11, no. 9 (2023). https://doi.org/10.3390/microorganisms11092155

Vilibić Čavlek, T., et al. (2023) 'Detection of Bhanja Bandavirus in Patients with Neuroinvasive Disease of Unknown Etiology in Croatia', Microorganisms, 11(9). doi: 10.3390/microorganisms11092155

Vilibić Čavlek T, Stevanović V, Krčmar S, Savić V, Kovač S, Bogdanić M, and sur.. Detection of Bhanja Bandavirus in Patients with Neuroinvasive Disease of Unknown Etiology in Croatia. Microorganisms [Internet]. 2023 August 25 [cited 2024 June 24];11(9). doi: 10.3390/microorganisms11092155

T. Vilibić Čavlek, et al., "Detection of Bhanja Bandavirus in Patients with Neuroinvasive Disease of Unknown Etiology in Croatia", Microorganisms, vol. 11, no. 9, August 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:815630. [Accessed: 24 June 2024]

Metadata
Title (english)Detection of Bhanja Bandavirus in Patients with Neuroinvasive Disease of Unknown Etiology in Croatia
AuthorTatjana Vilibić-Čavlek
AuthorVladimir Stevanović
AuthorStjepan Krčmar
AuthorVladimir Savić
AuthorSnježana Kovač
AuthorMaja Bogdanić
AuthorMaja Maurić Maljković
AuthorDario Sabadi
AuthorMarija Santini
AuthorTanja Potočnik-Hunjadi
AuthorMahmoud Al-Mufleh
AuthorLjubo Barbić
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Infectious Diseases)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Medical Microbiology and Parasitology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Infectology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Medical Microbiology
Abstract (english)
Background: Although the Bhanja bandavirus (BHAV) is widely distributed in some European countries, human infections are rarely reported. This study analyzed the prevalence of BHAV antibodies in patients with neuroinvasive diseases of unsolved etiology. Methods: A total of 254 Croatian patients who developed neurological symptoms during the four consecutive arbovirus transmission seasons (April 2017-October 2021) were tested. Cerebrospinal fluid (CSF) and urine samples were tested using RT-qPCR. In addition, CSF and serum samples were tested using a virus neutralization test. Results: BHAV RNA was not detected in any samples, while neutralizing (NT) antibodies were detected in serum samples of 53/20.8% of patients (95% CI = 16.0-26.3). In two patients, BHAV NT antibodies were detected in the CSF, indicating a recent infection. Both patients were inhabitants of rural areas in continental Croatia, and one reported a tick bite two weeks before symptoms onset. The seropositivity was high in all age groups (15.2-29.1%). The majority of seropositive patients (94.3%) resided at altitudes less than 200 m above sea level. The prevalence rates correlated positively with population density and negatively with certain climate parameters (temperature, number of hot/warm days). Conclusions: The presented results indicate that BHAV is distributed in Croatia. Further studies are needed to determine the clinical significance of this neglected arbovirus.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleMicroorganisms
Numberingvol. 11, no. 9, 2155
e-ISSN2076-2607
DOIhttps://doi.org/10.3390/microorganisms11092155
URN:NBNurn:nbn:hr:105:815630
Publication2023-08-25
ProjectNumber: IP-2016-06-7456
Title (croatian): Prevalencija i molekularna epidemiologija emergentnih i re-emergentnih neuroinvazivnih arbovirusnih infekcija na području Hrvatske
Acronym: CRONEUROARBO
Leader: Tatjana Vilibić Čavlek
Jurisdiction: Croatia
Funding stream: Research Projects
Document URLhttps://www.mdpi.com/2076-2607/11/9/2155
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-05-20 09:13:21