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Detection of Bhanja Bandavirus in Patients with Neuroinvasive Disease of Unknown Etiology in Croatia
Microorganisms, 11 (2023), 9; 2155. https://doi.org/10.3390/microorganisms11092155
Vilibić-Čavlek, Tatjana; Stevanović, Vladimir; Krčmar, Stjepan; Savić, Vladimir; Kovač, Snježana; Bogdanić, Maja; Maurić Maljković, Maja; Sabadi, Dario; Santini, Marija; Potočnik-Hunjadi, Tanja; Al-Mufleh, Mahmoud; Barbić, Ljubo

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Citirajte ovaj rad

Vilibić Čavlek, T., Stevanović, V., Krčmar, S., Savić, V., Kovač, S., Bogdanić, M. ... Barbić, Lj. (2023). Detection of Bhanja Bandavirus in Patients with Neuroinvasive Disease of Unknown Etiology in Croatia. Microorganisms, 11. (9). doi: 10.3390/microorganisms11092155

Vilibić Čavlek, Tatjana, et al. "Detection of Bhanja Bandavirus in Patients with Neuroinvasive Disease of Unknown Etiology in Croatia." Microorganisms, vol. 11, br. 9, 2023. https://doi.org/10.3390/microorganisms11092155

Vilibić Čavlek, Tatjana, Vladimir Stevanović, Stjepan Krčmar, Vladimir Savić, Snježana Kovač, Maja Bogdanić, Maja Maurić Maljković, et al. "Detection of Bhanja Bandavirus in Patients with Neuroinvasive Disease of Unknown Etiology in Croatia." Microorganisms 11, br. 9 (2023). https://doi.org/10.3390/microorganisms11092155

Vilibić Čavlek, T., et al. (2023) 'Detection of Bhanja Bandavirus in Patients with Neuroinvasive Disease of Unknown Etiology in Croatia', Microorganisms, 11(9). doi: 10.3390/microorganisms11092155

Vilibić Čavlek T, Stevanović V, Krčmar S, Savić V, Kovač S, Bogdanić M, i sur.. Detection of Bhanja Bandavirus in Patients with Neuroinvasive Disease of Unknown Etiology in Croatia. Microorganisms [Internet]. 25.08.2023. [pristupljeno 24.06.2024.];11(9). doi: 10.3390/microorganisms11092155

T. Vilibić Čavlek, et al., "Detection of Bhanja Bandavirus in Patients with Neuroinvasive Disease of Unknown Etiology in Croatia", Microorganisms, vol. 11, br. 9, Kolovoz 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:815630. [Citirano: 24.06.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:815630
Podaci o radu
Naslov (engleski)Detection of Bhanja Bandavirus in Patients with Neuroinvasive Disease of Unknown Etiology in Croatia
AutorTatjana Vilibić-Čavlek
AutorVladimir Stevanović
AutorStjepan Krčmar
AutorVladimir Savić
AutorSnježana Kovač
AutorMaja Bogdanić
AutorMaja Maurić Maljković
AutorDario Sabadi
AutorMarija Santini
AutorTanja Potočnik-Hunjadi
AutorMahmoud Al-Mufleh
AutorLjubo Barbić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INFEKTOLOGIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA MEDICINSKU MIKROBIOLOGIJU I PARAZITOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Infektologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Medicinska mikrobiologija
Sažetak (engleski)
Background: Although the Bhanja bandavirus (BHAV) is widely distributed in some European countries, human infections are rarely reported. This study analyzed the prevalence of BHAV antibodies in patients with neuroinvasive diseases of unsolved etiology. Methods: A total of 254 Croatian patients who developed neurological symptoms during the four consecutive arbovirus transmission seasons (April 2017-October 2021) were tested. Cerebrospinal fluid (CSF) and urine samples were tested using RT-qPCR. In addition, CSF and serum samples were tested using a virus neutralization test. Results: BHAV RNA was not detected in any samples, while neutralizing (NT) antibodies were detected in serum samples of 53/20.8% of patients (95% CI = 16.0-26.3). In two patients, BHAV NT antibodies were detected in the CSF, indicating a recent infection. Both patients were inhabitants of rural areas in continental Croatia, and one reported a tick bite two weeks before symptoms onset. The seropositivity was high in all age groups (15.2-29.1%). The majority of seropositive patients (94.3%) resided at altitudes less than 200 m above sea level. The prevalence rates correlated positively with population density and negatively with certain climate parameters (temperature, number of hot/warm days). Conclusions: The presented results indicate that BHAV is distributed in Croatia. Further studies are needed to determine the clinical significance of this neglected arbovirus.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaMicroorganisms
Brojčani podacivol. 11, br. 9, 2155
e-ISSN2076-2607
DOIhttps://doi.org/10.3390/microorganisms11092155
URN:NBNurn:nbn:hr:105:815630
Datum objave publikacije2023-08-25
ProjektŠifra: IP-2016-06-7456
Naziv (hrvatski): Prevalencija i molekularna epidemiologija emergentnih i re-emergentnih neuroinvazivnih arbovirusnih infekcija na području Hrvatske
Kratica: CRONEUROARBO
Voditelj: Tatjana Vilibić Čavlek
Pravna nadležnost: Hrvatska
Financijer: Hrvatska zaklada za znanost
Linija financiranja: Research Projects
URL dokumentahttps://www.mdpi.com/2076-2607/11/9/2155
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-05-20 09:13:21