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undergraduate thesis
Potencijal antioksidativnih tvari u sprječavanju toksičnih učinaka polikloriranih bifenila
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2014. urn:nbn:hr:159:757857
Budimir, Jelena
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Chemistry and Biochemistry
Laboratory for Toxicology

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

Cite this document

Budimir, J. (2014). Potencijal antioksidativnih tvari u sprječavanju toksičnih učinaka polikloriranih bifenila (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:757857

Budimir, Jelena. "Potencijal antioksidativnih tvari u sprječavanju toksičnih učinaka polikloriranih bifenila." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2014. https://urn.nsk.hr/urn:nbn:hr:159:757857

Budimir, Jelena. "Potencijal antioksidativnih tvari u sprječavanju toksičnih učinaka polikloriranih bifenila." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2014. https://urn.nsk.hr/urn:nbn:hr:159:757857

Budimir, J. (2014). 'Potencijal antioksidativnih tvari u sprječavanju toksičnih učinaka polikloriranih bifenila', Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 19 December 2024, https://urn.nsk.hr/urn:nbn:hr:159:757857

Budimir J. Potencijal antioksidativnih tvari u sprječavanju toksičnih učinaka polikloriranih bifenila [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2014 [cited 2024 December 19] Available at: https://urn.nsk.hr/urn:nbn:hr:159:757857

J. Budimir, "Potencijal antioksidativnih tvari u sprječavanju toksičnih učinaka polikloriranih bifenila", Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2014. Available at: https://urn.nsk.hr/urn:nbn:hr:159:757857

Metadata
TitlePotencijal antioksidativnih tvari u sprječavanju toksičnih učinaka polikloriranih bifenila
Title (english)Potential of antioxidants in preventing toxic effects of polychlorinated biphenyls
AuthorJelena Budimir
MentorIvana Kmetič (mentor)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Chemistry and Biochemistry)
(Laboratory for Toxicology)
Zagreb
Defense date and country2014-09-11, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Nutrition
Abstract
Oksidacijski stres je poremećaj ravnoteže između slobodnih radikala u organizmu te mehanizama kojima organizam neutralizira slobodne radikale. Mogući su endogeni i egzogeni izvori slobodnih radikala. Endogeni nastaju procesima metabolizma energije u organizmu, dok egzogeni nastaju kao posljedica unosa različitih ksenobiotika u organizam. Poliklorirani bifenili su aromatski ugljikovodici koji sadrže klorove supstituente na bifenilnom prstenu. Spadaju u skupinu ksenobiotika koja uzrokuje nastanak reaktivnih kisikovih vrsta, stoga mogu izazvati mutagenezu stanice, oštećenja DNA i stanica te apoptozu. Mehanizmi kojima organizam neutralizira slobodne radikale obuhvaćaju endogene i egzogene mehanizme, uključujući enzimske i neenzimske. U ovom radu provedeno je preliminarno ispitivanje utjecaja resveratrola na oksidacijski stres izazvan kongenerima PCB-77 i PCB-153 te kombinacijom navedenih kongenera na CHO-K1 staničnu liniju. Resveratrol nije pokazao protektivan antioksidacijski učinak prilikom predinkubacije CHO-K1 stanica s PCB-77, PCB-153 ni kombincijom tih kongenera.
Abstract (english)
Oxidative stress is defined as imbalance between production of free radicals in the organism and mechanism of their neutralization. The source of free radicals can be endogenous and exogenous. Endogenous free radicals are nusproducts of metabolism of energy, while egzogenous free radicals can be produced as consequence of xenobiotic intake. Polychlorinated biphenyls are aromatic hydrocarbons that contain chlorine supstituents in biphenyl ring. PCBs belong to a group of xenobiotics that induces the generation of reactive oxygen species which can lead to mutagenesis, cell and DNA damage and apoptosis. Free radical neutralization mehanisms can be endogenous and egzogenous mechanism, inclouding enzymatic and nonenzymatic. This preliminary thesis examines influence of resveratrol pretreatmant of CHO-K1 cell line on oxidative stress incuded by PCB-77 and PCB-153 congeners and the combination of this congeners. Resveratrol showed no protective antioxidative effect in preincubated CHO-K1 cells after exposure to PCB-77 and PCB-153 congener, as with a combination of these congeners.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:757857
Study programmeTitle: Nutrition
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) nutricionizma (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) nutricionizma)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
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Created on2017-04-26 10:08:08