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undergraduate thesis
Mikrovalna sinteza ferocenskih kurkuminoid-pirazola
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2021. urn:nbn:hr:159:210642
Dolenec, Filip
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Chemistry and Biochemistry
Laboratory for Organic Chemistry

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

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Dolenec, F. (2021). Mikrovalna sinteza ferocenskih kurkuminoid-pirazola (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:210642

Dolenec, Filip. "Mikrovalna sinteza ferocenskih kurkuminoid-pirazola." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2021. https://urn.nsk.hr/urn:nbn:hr:159:210642

Dolenec, Filip. "Mikrovalna sinteza ferocenskih kurkuminoid-pirazola." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2021. https://urn.nsk.hr/urn:nbn:hr:159:210642

Dolenec, F. (2021). 'Mikrovalna sinteza ferocenskih kurkuminoid-pirazola', Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 05 August 2024, https://urn.nsk.hr/urn:nbn:hr:159:210642

Dolenec F. Mikrovalna sinteza ferocenskih kurkuminoid-pirazola [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2021 [cited 2024 August 05] Available at: https://urn.nsk.hr/urn:nbn:hr:159:210642

F. Dolenec, "Mikrovalna sinteza ferocenskih kurkuminoid-pirazola", Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:159:210642

Metadata
TitleMikrovalna sinteza ferocenskih kurkuminoid-pirazola
Title (english)Microwave assisted synthesis of feocene-containing curcuminoid pyrazoles
AuthorFilip Dolenec
MentorVeronika Kovač (mentor)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Chemistry and Biochemistry)
(Laboratory for Organic Chemistry)
Zagreb
Defense date and country2021-09-08, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Nutrition
Abstract
Kemijskom pretvorbom kurkumina u pirazolne derivate nastoje se izbjeći negativne karakteristike kurkumina poput kemijske nestabilnosti i slabe biodostupnosti, te povećati njegovo biološko djelovanje (antikancerogeno, antimikrobno, antioksidativno djelovanje). Mikrovalnom sintezom postiže se kraće reakcijsko vrijeme, bolje iskorištenje, veća čistoća produkata te jednoliko i selektivno zagrijavanje. Cilj ovoga rada bio je sintetizirati tri ferocenska kurkuminoid-pirazola primjenom mikrovalnog zračenja, te usporediti rezultate mikrovalne sinteze s već ranije provedenim klasičnim kemijskim sintezama navedenih spojeva. Reakcije sinteze ferocenskih kurmuminoid-pirazola 2, 3 i 4 provedene su u mikrovalnom reaktoru, a iskorištenje reakcija je iznosilo, redom, 60%, 69% i 52%. Mikrovalnom sintezom spojeva 2, 3 i 4 postignuto je kraće vrijeme trajanja reakcije te bolje iskorištenje reakcije nego klasičnom kemijskom sintezom.
Abstract (english)
Chemical conversion of curcumin into pyrazole derivatives is aimed at avoiding negative characteristics of curcumin (such as chemical instability and low bioavailability), as well as at increasing its biological activity (anticancer, antimicrobial and antioxidant activity). Microwave-assisted synthesis achieves shorter reaction times, better yield, higher product purity, and uniform and selective heating. The aim of this thesis was to synthesize three ferrocene curcuminoid-pyrazoles by using microwave radiation and to compare the results of microwave synthesis with the previously conducted conventional chemical synthesis of the mentioned compounds. The synthesis of the ferrocene curcuminoid pyrazoles 2, 3 and 4 was carried out in a microwave reactor, and the yield of the reaction was 60%, 69% and 52%, respectively. In comparison with conventional chemical synthesis, microwave-assisted synthesis of compounds 2, 3 and 4 achieved a shorter reaction time and better reaction yield.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:210642
Study programmeTitle: Nutrition
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) nutricionizma (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) nutricionizma)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0) icon
Created on2021-09-24 10:52:59