prikaz prve stranice dokumenta Synthesis and functionalization of porous silicon nanoparticles for nucleic acid delivery and photodynamic therapy
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master's thesis
Synthesis and functionalization of porous silicon nanoparticles for nucleic acid delivery and photodynamic therapy
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2013. urn:nbn:hr:159:355437
Ivašković, Petra
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Chemistry and Biochemistry
Laboratory for Biochemistry

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

Cite this document

Ivašković, P. (2013). Synthesis and functionalization of porous silicon nanoparticles for nucleic acid delivery and photodynamic therapy (Master's thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:355437

Ivašković, Petra. "Synthesis and functionalization of porous silicon nanoparticles for nucleic acid delivery and photodynamic therapy." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2013. https://urn.nsk.hr/urn:nbn:hr:159:355437

Ivašković, Petra. "Synthesis and functionalization of porous silicon nanoparticles for nucleic acid delivery and photodynamic therapy." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2013. https://urn.nsk.hr/urn:nbn:hr:159:355437

Ivašković, P. (2013). 'Synthesis and functionalization of porous silicon nanoparticles for nucleic acid delivery and photodynamic therapy', Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 27 December 2024, https://urn.nsk.hr/urn:nbn:hr:159:355437

Ivašković P. Synthesis and functionalization of porous silicon nanoparticles for nucleic acid delivery and photodynamic therapy [Master's thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2013 [cited 2024 December 27] Available at: https://urn.nsk.hr/urn:nbn:hr:159:355437

P. Ivašković, "Synthesis and functionalization of porous silicon nanoparticles for nucleic acid delivery and photodynamic therapy", Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2013. Available at: https://urn.nsk.hr/urn:nbn:hr:159:355437

Metadata
TitleSynthesis and functionalization of porous silicon nanoparticles for nucleic acid delivery and photodynamic therapy
AuthorPetra Ivašković
MentorVladimir Mrša (mentor)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Chemistry and Biochemistry)
(Laboratory for Biochemistry)
Zagreb
Defense date and country2013-07-01, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract
In recent years there has been a significant increase in research on biomedical applications of nanoparticles. They have attracted much attention due to their ability to encapsulate and release a diversity of therapeutics or genes to the organism in an effective and selective way. Among different nanocarriers, the porous silicon nanoparticles show some advantages due to their desirable properties such as biocompatibility, non-toxic degradation products, tunable pore sizes and volumes with a high payload capacity, a high surface area and an efficient photoluminescence. The aim of this project was functionalization of the porous silicon nanoparticles applied in two different cancer therapy approaches: immunotherapy and photodynamic therapy (PDT). The porous silicon nanoparticles were functionalized with histidine and lysine, the amino acids able to complex the nucleic acids. They were also functionalized with a photosensitizer porphyrin and the targeting agent, mannose. The nanoparticles were characterized by IR spectroscopy and quantification was done by UV-Vis spectroscopy. The effectiveness of functionalized nanoparticles was tested in vitro in two-photon excitation photodynamic therapy on MCF-7 cells.
Keywords
Languageenglish
URN:NBNurn:nbn:hr:159:355437
Study programmeTitle: Molecular Biotechnology
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra inženjer/inženjerka molekularne biotehnologije (magistar/magistra inženjer/inženjerka molekularne biotehnologije)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2017-05-04 10:16:41