prikaz prve stranice dokumenta Synthesis and functionalization of porous silicon nanoparticles for nucleic acid delivery and photodynamic therapy
Pristup korisnicima matične ustanove
diplomski rad
Synthesis and functionalization of porous silicon nanoparticles for nucleic acid delivery and photodynamic therapy
Zagreb: Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet, 2013. urn:nbn:hr:159:355437
Ivašković, Petra
Sveučilište u Zagrebu
Prehrambeno-biotehnološki fakultet
Zavod za kemiju i biokemiju
Laboratorij za biokemiju

Institucijski repozitorij: Repozitorij Prehrambeno-biotehnološkog fakulteta u Zagrebu

Citirajte ovaj rad

Ivašković, P. (2013). Synthesis and functionalization of porous silicon nanoparticles for nucleic acid delivery and photodynamic therapy (Diplomski rad). Zagreb: Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:159:355437

Ivašković, Petra. "Synthesis and functionalization of porous silicon nanoparticles for nucleic acid delivery and photodynamic therapy." Diplomski rad, Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet, 2013. https://urn.nsk.hr/urn:nbn:hr:159:355437

Ivašković, Petra. "Synthesis and functionalization of porous silicon nanoparticles for nucleic acid delivery and photodynamic therapy." Diplomski rad, Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet, 2013. https://urn.nsk.hr/urn:nbn:hr:159:355437

Ivašković, P. (2013). 'Synthesis and functionalization of porous silicon nanoparticles for nucleic acid delivery and photodynamic therapy', Diplomski rad, Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet, citirano: 19.05.2024., https://urn.nsk.hr/urn:nbn:hr:159:355437

Ivašković P. Synthesis and functionalization of porous silicon nanoparticles for nucleic acid delivery and photodynamic therapy [Diplomski rad]. Zagreb: Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet; 2013 [pristupljeno 19.05.2024.] Dostupno na: https://urn.nsk.hr/urn:nbn:hr:159:355437

P. Ivašković, "Synthesis and functionalization of porous silicon nanoparticles for nucleic acid delivery and photodynamic therapy", Diplomski rad, Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet, Zagreb, 2013. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:159:355437

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:159:355437
Podaci o radu
NaslovSynthesis and functionalization of porous silicon nanoparticles for nucleic acid delivery and photodynamic therapy
AutorPetra Ivašković
MentorVladimir Mrša (mentor)
Ustanova koja je dodijelila
akademski / stručni stupanj		Sveučilište u Zagrebu
Prehrambeno-biotehnološki fakultet
(Zavod za kemiju i biokemiju)
(Laboratorij za biokemiju)
Zagreb
Datum i država obrane2013-07-01, Hrvatska
Znanstveno / umjetničko
područje, polje i grana		BIOTEHNIČKE ZNANOSTI
Biotehnologija
Sažetak
In recent years there has been a significant increase in research on biomedical applications of nanoparticles. They have attracted much attention due to their ability to encapsulate and release a diversity of therapeutics or genes to the organism in an effective and selective way. Among different nanocarriers, the porous silicon nanoparticles show some advantages due to their desirable properties such as biocompatibility, non-toxic degradation products, tunable pore sizes and volumes with a high payload capacity, a high surface area and an efficient photoluminescence. The aim of this project was functionalization of the porous silicon nanoparticles applied in two different cancer therapy approaches: immunotherapy and photodynamic therapy (PDT). The porous silicon nanoparticles were functionalized with histidine and lysine, the amino acids able to complex the nucleic acids. They were also functionalized with a photosensitizer porphyrin and the targeting agent, mannose. The nanoparticles were characterized by IR spectroscopy and quantification was done by UV-Vis spectroscopy. The effectiveness of functionalized nanoparticles was tested in vitro in two-photon excitation photodynamic therapy on MCF-7 cells.
Ključne riječi
Jezikengleski
URN:NBNurn:nbn:hr:159:355437
Studijski programNaziv: Molekularna biotehnologija
Vrsta studija: sveučilišni
Stupanj studija: diplomski
Akademski / stručni naziv: magistar/magistra inženjer/inženjerka molekularne biotehnologije (mag. ing. biotechn.)
Vrsta resursaTekst
Način izrade datotekeIzvorno digitalna
Prava pristupaPristup korisnicima matične ustanove
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2017-05-04 10:16:41