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master's thesis
Asimetrična redukcija 3,4-dimetilacetofenona pomoću NaBH4 i bioloških katalizatora
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2012. urn:nbn:hr:159:933748
Potočki, Ana
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Biochemical Engineering
Laboratory for Cell Technology, Application and Biotransformations

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

Cite this document

Potočki, A. (2012). Asimetrična redukcija 3,4-dimetilacetofenona pomoću NaBH4 i bioloških katalizatora (Master's thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:933748

Potočki, Ana. "Asimetrična redukcija 3,4-dimetilacetofenona pomoću NaBH4 i bioloških katalizatora." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2012. https://urn.nsk.hr/urn:nbn:hr:159:933748

Potočki, Ana. "Asimetrična redukcija 3,4-dimetilacetofenona pomoću NaBH4 i bioloških katalizatora." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2012. https://urn.nsk.hr/urn:nbn:hr:159:933748

Potočki, A. (2012). 'Asimetrična redukcija 3,4-dimetilacetofenona pomoću NaBH4 i bioloških katalizatora', Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 03 October 2024, https://urn.nsk.hr/urn:nbn:hr:159:933748

Potočki A. Asimetrična redukcija 3,4-dimetilacetofenona pomoću NaBH4 i bioloških katalizatora [Master's thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2012 [cited 2024 October 03] Available at: https://urn.nsk.hr/urn:nbn:hr:159:933748

A. Potočki, "Asimetrična redukcija 3,4-dimetilacetofenona pomoću NaBH4 i bioloških katalizatora", Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2012. Available at: https://urn.nsk.hr/urn:nbn:hr:159:933748

Metadata
TitleAsimetrična redukcija 3,4-dimetilacetofenona pomoću NaBH4 i bioloških katalizatora
Title (english)Asymmetric reduction of 3,4-dimethylacetophenone by NaBH4 and biocatalysts
AuthorAna Potočki
MentorJasna Vorkapić-Furač (mentor)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Biochemical Engineering)
(Laboratory for Cell Technology, Application and Biotransformations)
Zagreb
Defense date and country2012-09-25, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract
U ovom je radu provedena asimetrična redukcija 3,4-dimetil acetofenona u 1-(3,4dimetilfenil)etanol u vodi kao zelenom otapalu uz mikrovalnu aktivaciju, pomoću kvasca Saccharomyces cerevisiae i dijelova različitih biljaka (graha, slanutka i leće) kao zelenim biokatalizatorima. Navedeni biokatalizatori su pomoću svojih enzima izveli asimetričnu redukciju supstrata, čime se pokazala njihova povoljna uporaba u biotransformacijama prema principima zelene kemije. Radi usporedbe enantioselektivnosti, izvedena je redukcija 3,4dimetilacetofenona u 1-(3,4-dimetilfenil)etanol pomoću natrijeva tetrahidroborata klasičnom organskom sintezom u etanolu u prisutnosti β-ciklodekstrina. Struktura sintetiziranog spoja 1-(3,4-dimetilfenil)etanola određena je IR-spektroskopijom, 1H- i 13C-nuklearnom magnetskom rezonancijom, a apsolutne konfiguracije kiralnog alkohola 1-(3,4dimetilfenil)etanola određene su kiralnom HPLC.
Abstract (english)
In this paper novel asymmetric reduction of 3,4-dimethylacetophenone into 1-(3,4dimetphenyl)ethanol was carried out in water as green solvent using microwave activation, by using baker's yeast S. cerevisiae and parts of plants (beans, chick pea and lentil) as green biocatalysts. The enzymes of these biocatalysts preformed the asymmetric reduction of a substrate, showing why they are good for using in biotransformations according to the principles of green chemistry. For comparison of enantioselectivity, the reduction of 3,4dimethylacetophenone into 1-(3,4-dimethylphenyl)ethanol with sodium tetrahydroborate in ethanol in the presence of β-cyclodextrin was preformed, too. Structure of compound 1-(3,4dimethylyphenyl)ethanol was determined by IR spectroscopy, 1H- and 13C-nuclear magnetic resonance, and absolute configurations of chiral alcohol 1-(3,4-dimethylphenyl)ethanol by chiral HPLC.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:933748
Study programmeTitle: Bioprocess Engineering
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra inženjer/inženjerka bioprocesnog inženjerstva (magistar/magistra inženjer/inženjerka bioprocesnog inženjerstva)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
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Created on2017-05-09 08:44:41