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master's thesis
Sinteza i karakterizacija novih urea klorokina s aminoalkoholima
Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2019. urn:nbn:hr:163:807097
Plavša, Branimir
University of Zagreb
Faculty of Pharmacy and Biochemistry
Department of medicinal chemistry

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

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Plavša, B. (2019). Sinteza i karakterizacija novih urea klorokina s aminoalkoholima (Master's thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:807097

Plavša, Branimir. "Sinteza i karakterizacija novih urea klorokina s aminoalkoholima." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2019. https://urn.nsk.hr/urn:nbn:hr:163:807097

Plavša, Branimir. "Sinteza i karakterizacija novih urea klorokina s aminoalkoholima." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2019. https://urn.nsk.hr/urn:nbn:hr:163:807097

Plavša, B. (2019). 'Sinteza i karakterizacija novih urea klorokina s aminoalkoholima', Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 23 December 2024, https://urn.nsk.hr/urn:nbn:hr:163:807097

Plavša B. Sinteza i karakterizacija novih urea klorokina s aminoalkoholima [Master's thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2019 [cited 2024 December 23] Available at: https://urn.nsk.hr/urn:nbn:hr:163:807097

B. Plavša, "Sinteza i karakterizacija novih urea klorokina s aminoalkoholima", Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:163:807097

Metadata
TitleSinteza i karakterizacija novih urea klorokina s aminoalkoholima
Title (english)Synthesis and charachterisation of new urea derivatives of chloroquine and aminoalcohols
AuthorBranimir Plavša
MentorZrinka Rajić (mentor)
Committee memberZrinka Rajić (predsjednik povjerenstva)
Committee memberBranka Zorc (član povjerenstva)
Committee memberDavor Šakić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of medicinal chemistry)
Zagreb
Defense date and country2019-05-17, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract
Klorokin je antimalarijski lijek za kojeg je poznato da ima i antitumorsko djelovanje. U ovom radu dan je pregled literaturnih podataka o antitumorskom djelovanju antimalarika, s naglaskom na klorokinu, kao i o njihovom potencijalu da posluže kao spojevi uzori za sintezu novih antitumorskih lijekova. Detaljnije je opisan proces autofagije, budući da se smatra da je glavni mehanizam kojim klorokin inhibira preživljavanje stanica raka vezan uz inhibiciju autofagije. U svrhu daljnjeg istraživanja potencijalne antitumorske aktivnosti derivata klorokina sintetizirano je 5 novih spojeva: BtcCQ (3) i uree 4a-d. Novosintetizirani spojevi su okarakterizirani uobičajenim analitičkim tehnikama (IR, MS, 1H i 13C NMR). Spojevi 3 i 4a-d u potpunosti odgovaraju Lipinskijevim, Gelovanijevim i Veberovim pravilima, odnosno kriterijima alata Bioavailability radar (SwissAdme). U daljnjim istraživanjima, koja prelaze okvire ovoga diplomskog rada, bit će ispitano njihovo citostatsko djelovanje.
Abstract (english)
Chloroquine is an antimalarial drug with well-known cytostatic properties. This thesis gives an overview of the current literature regarding the cytotoxic activity of antimalarials and their potential to serve as lead compounds for the synthesis of new anticancer agents. The process of autophagy is described in more detail since it is believed that chloroquine owes its anticancer activity to the inhibition of autophagy. Five novel chloroquine derivatives were synthesized: BtcCQ (3) and ureas 4a-d. Newly synthesized compounds were characterized by standard analytical techniques (IR, MS, 1H and 13C NMR). Compounds 3 and 4a-d comply with Lipinski, Gelovani and Veber rules, as well as with the criteria of Bioavailability radar (SwissAdme). Future investigations will focus on the evaluation of their cytostatic activity.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:163:807097
Study programmeTitle: Pharmacy
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-02-12 13:15:51