prikaz prve stranice dokumenta In vitro evaluation of stearylamine cationic nanoemulsions for improved ocular drug delivery
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Scientific paper - Original scientific paper
In vitro evaluation of stearylamine cationic nanoemulsions for improved ocular drug delivery
Acta Pharmaceutica, 69 (2019), 4; 621-634. https://doi.org/10.2478/acph-2019-0054
Jurišić Dukovski, Bisera; Bračko, Ana; Šare, Marija; Pepić, Ivan; Lovrić, Jasmina

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Jurišić Dukovski, B., Bračko, A., Šare, M., Pepić, I. & Lovrić, J. (2019). In vitro evaluation of stearylamine cationic nanoemulsions for improved ocular drug delivery. Acta Pharmaceutica, 69. (4), 621-634. doi: 10.2478/acph-2019-0054

Jurišić Dukovski, Bisera, et al. "In vitro evaluation of stearylamine cationic nanoemulsions for improved ocular drug delivery." Acta Pharmaceutica, vol. 69, no. 4, 2019, pp. 621-634. https://doi.org/10.2478/acph-2019-0054

Jurišić Dukovski, Bisera, Ana Bračko, Marija Šare, Ivan Pepić and Jasmina Lovrić. "In vitro evaluation of stearylamine cationic nanoemulsions for improved ocular drug delivery." Acta Pharmaceutica 69, no. 4 (2019): 621-634. https://doi.org/10.2478/acph-2019-0054

Jurišić Dukovski, B., et al. (2019) 'In vitro evaluation of stearylamine cationic nanoemulsions for improved ocular drug delivery', Acta Pharmaceutica, 69(4), pp. 621-634. doi: 10.2478/acph-2019-0054

Jurišić Dukovski B, Bračko A, Šare M, Pepić I, Lovrić J. In vitro evaluation of stearylamine cationic nanoemulsions for improved ocular drug delivery. Acta Pharmaceutica [Internet]. 2019 [cited 2024 November 22];69(4):621-634. doi: 10.2478/acph-2019-0054

B. Jurišić Dukovski, A. Bračko, M. Šare, I. Pepić and J. Lovrić, "In vitro evaluation of stearylamine cationic nanoemulsions for improved ocular drug delivery", Acta Pharmaceutica, vol. 69, no. 4, pp. 621-634, 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:163:198382. [Accessed: 22 November 2024]

Metadata
Title (english)In vitro evaluation of stearylamine cationic nanoemulsions for improved ocular drug delivery
AuthorBisera Jurišić Dukovski
AuthorAna Bračko
AuthorMarija Šare
AuthorIvan Pepić
AuthorJasmina Lovrić
Author's institutionUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of pharmaceutical technology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract (english)
Oil-in-water nanoemulsions (NEs) represent one of the formulation approaches to improve eye-related bioavailability of lipophilic drugs. The potential of cationic NEs is pronounced due to the electrostatic interaction of positively charged droplets with negatively charged mucins present in the tear film, providing prolonged formulation residence at the ocular surface. The aim of this study was to develop a cationic ophthalmic NE with cationic lipid stearylamine (SA) as a carrier of a positive charge. The addition of a nonionic surfactant provided the dual electro-steric stabilization of NEs and enabled tuning of SA concentration to achieve an optimal balance between its interaction with mucins and biocompatibility. Physicochemical characterization, stability profile, in vitro mucoadhesion study and biocompatibility study employing 3D HCE-T cell-based model of corneal epithelium pointed out the NE with 0.05 % (m/m) SA as the leading formulation. Minimizing SA content while retaining droplet/mucin interactions is of great importance for efficacy and safety of future ophthalmic drug products.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleActa Pharmaceutica
Numberingvol. 69, no. 4, pp. 621-634
p-ISSN1330-0075
e-ISSN1846-9558
DOIhttps://doi.org/10.2478/acph-2019-0054
URN:NBNurn:nbn:hr:163:198382
Publication2019
Document URLhttps://hrcak.srce.hr/225428
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-04-07 14:50:55