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In vitro evaluation of stearylamine cationic nanoemulsions for improved ocular drug delivery
Acta Pharmaceutica, 69 (2019), 4; 621-634. https://doi.org/10.2478/acph-2019-0054
Jurišić Dukovski, Bisera; Bračko, Ana; Šare, Marija; Pepić, Ivan; Lovrić, Jasmina

Institucijski repozitorij: Repozitorij Farmaceutsko-biokemijskog fakulteta Sveučilišta u Zagrebu

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Jurišić Dukovski, B., Bračko, A., Šare, M., Pepić, I. i Lovrić, J. (2019). In vitro evaluation of stearylamine cationic nanoemulsions for improved ocular drug delivery. Acta Pharmaceutica, 69. (4), 621-634. doi: 10.2478/acph-2019-0054

Jurišić Dukovski, Bisera, et al. "In vitro evaluation of stearylamine cationic nanoemulsions for improved ocular drug delivery." Acta Pharmaceutica, vol. 69, br. 4, 2019, str. 621-634. https://doi.org/10.2478/acph-2019-0054

Jurišić Dukovski, Bisera, Ana Bračko, Marija Šare, Ivan Pepić i Jasmina Lovrić. "In vitro evaluation of stearylamine cationic nanoemulsions for improved ocular drug delivery." Acta Pharmaceutica 69, br. 4 (2019): 621-634. https://doi.org/10.2478/acph-2019-0054

Jurišić Dukovski, B., et al. (2019) 'In vitro evaluation of stearylamine cationic nanoemulsions for improved ocular drug delivery', Acta Pharmaceutica, 69(4), str. 621-634. doi: 10.2478/acph-2019-0054

Jurišić Dukovski B, Bračko A, Šare M, Pepić I, Lovrić J. In vitro evaluation of stearylamine cationic nanoemulsions for improved ocular drug delivery. Acta Pharmaceutica [Internet]. 2019. [pristupljeno 23.12.2024.];69(4):621-634. doi: 10.2478/acph-2019-0054

B. Jurišić Dukovski, A. Bračko, M. Šare, I. Pepić i J. Lovrić, "In vitro evaluation of stearylamine cationic nanoemulsions for improved ocular drug delivery", Acta Pharmaceutica, vol. 69, br. 4, str. 621-634, 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:163:198382. [Citirano: 23.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:163:198382
Podaci o radu
Naslov (engleski)In vitro evaluation of stearylamine cationic nanoemulsions for improved ocular drug delivery
AutorBisera Jurišić Dukovski
AutorAna Bračko
AutorMarija Šare
AutorIvan Pepić
AutorJasmina Lovrić
Autorova ustanovaSveučilište u Zagrebu
Farmaceutsko-biokemijski fakultet
(Zavod za farmaceutsku tehnologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Farmacija
Farmacija
Sažetak (engleski)
Oil-in-water nanoemulsions (NEs) represent one of the formulation approaches to improve eye-related bioavailability of lipophilic drugs. The potential of cationic NEs is pronounced due to the electrostatic interaction of positively charged droplets with negatively charged mucins present in the tear film, providing prolonged formulation residence at the ocular surface. The aim of this study was to develop a cationic ophthalmic NE with cationic lipid stearylamine (SA) as a carrier of a positive charge. The addition of a nonionic surfactant provided the dual electro-steric stabilization of NEs and enabled tuning of SA concentration to achieve an optimal balance between its interaction with mucins and biocompatibility. Physicochemical characterization, stability profile, in vitro mucoadhesion study and biocompatibility study employing 3D HCE-T cell-based model of corneal epithelium pointed out the NE with 0.05 % (m/m) SA as the leading formulation. Minimizing SA content while retaining droplet/mucin interactions is of great importance for efficacy and safety of future ophthalmic drug products.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaActa Pharmaceutica
Brojčani podacivol. 69, br. 4, str. 621-634
p-ISSN1330-0075
e-ISSN1846-9558
DOIhttps://doi.org/10.2478/acph-2019-0054
URN:NBNurn:nbn:hr:163:198382
Datum objave publikacije2019
URL dokumentahttps://hrcak.srce.hr/225428
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2020-04-07 14:50:55