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Scientific paper - Original scientific paper
Synthesis, antibacterial and cytotoxic activity evaluation of hydroxyurea derivatives
Acta Pharmaceutica, 63 (2013), 2; 175-191. https://doi.org/10.2478/acph-2013-0014
Kos, Ivan; Jadrijević-Mladar Takač, Milena; Butula, Ivan; Biruš, Mladen; Maravić-Vlahoviček, Gordana; Dabelić, Sanja

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Kos, I., Jadrijević Mladar Takač, M., Butula, I., Biruš, M., Maravić Vlahoviček, G. & Dabelić, S. (2013). Synthesis, antibacterial and cytotoxic activity evaluation of hydroxyurea derivatives. Acta Pharmaceutica, 63. (2), 175-191. doi: 10.2478/acph-2013-0014

Kos, Ivan, et al. "Synthesis, antibacterial and cytotoxic activity evaluation of hydroxyurea derivatives." Acta Pharmaceutica, vol. 63, no. 2, 2013, pp. 175-191. https://doi.org/10.2478/acph-2013-0014

Kos, Ivan, Milena Jadrijević Mladar Takač, Ivan Butula, Mladen Biruš, Gordana Maravić Vlahoviček and Sanja Dabelić. "Synthesis, antibacterial and cytotoxic activity evaluation of hydroxyurea derivatives." Acta Pharmaceutica 63, no. 2 (2013): 175-191. https://doi.org/10.2478/acph-2013-0014

Kos, I., et al. (2013) 'Synthesis, antibacterial and cytotoxic activity evaluation of hydroxyurea derivatives', Acta Pharmaceutica, 63(2), pp. 175-191. doi: 10.2478/acph-2013-0014

Kos I, Jadrijević Mladar Takač M, Butula I, Biruš M, Maravić Vlahoviček G, Dabelić S. Synthesis, antibacterial and cytotoxic activity evaluation of hydroxyurea derivatives. Acta Pharmaceutica [Internet]. 2013 [cited 2024 December 27];63(2):175-191. doi: 10.2478/acph-2013-0014

I. Kos, M. Jadrijević Mladar Takač, I. Butula, M. Biruš, G. Maravić Vlahoviček and S. Dabelić, "Synthesis, antibacterial and cytotoxic activity evaluation of hydroxyurea derivatives", Acta Pharmaceutica, vol. 63, no. 2, pp. 175-191, 2013. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:163:181762. [Accessed: 27 December 2024]

Metadata
Title (english)Synthesis, antibacterial and cytotoxic activity evaluation of hydroxyurea derivatives
AuthorIvan Kos
AuthorMilena Jadrijević-Mladar Takač
AuthorIvan Butula
MBZ: 6372
AuthorMladen Biruš
AuthorGordana Maravić-Vlahoviček
AuthorSanja Dabelić
Author's institutionUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of analytical chemistry)
Author's institutionUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of medicinal chemistry)
Author's institutionUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of general and inorganic chemistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Abstract (english)
Synthesis and biological evaluation for a series (N = 16) of cyclic and acyclic hydroxyurea derivatives including benzotriazole-, isocyanuirc acid- and biuret-containing compounds, are disclosed. 1-N-(benzyloxycarbamoyl)benzotriazole was used as benzyloxyisocyanate donor, a useful intermediate in the preparation of substituted hydroxyurea. Antibacterial activities of synthesized hydroxyurea derivatives were tested on three E. coli strains, i.e., strain susceptible to antibiotics, strain resistant to macrolide antibiotics and strain resistant to aminoglycoside antibiotics. Six compounds (three acyclic and three cyclic hydroxyureas) showed the growth inhibition of tested E. coli strains, with different specificity toward each strain. Results of the cytotoxic activity evaluation revealed that twelve out of sixteen test compounds were cytotoxic to human acute monocytic leukemia THP-1 and/or on human acute T cell leukemia Jurkat cell line. 1-(N-hydroxycarbamoyl)benzotriazole (5) increased metabolic activity of both cell lines. Two compounds, 1-(N-hydroxycarbamoyl)benzotriazole (5) and N,N’,N’’-trihydroxybiuret (15) were identified as potential NO donors.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleActa Pharmaceutica
Numberingvol. 63, no. 2, pp. 175-191
p-ISSN1330-0075
e-ISSN1846-9558
DOIhttps://doi.org/10.2478/acph-2013-0014
URN:NBNurn:nbn:hr:163:181762
Publication2013
Document URLhttps://hrcak.srce.hr/97696
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-04-08 13:42:13