prikaz prve stranice dokumenta Synthesis, antibacterial and cytotoxic activity evaluation of hydroxyurea derivatives
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Synthesis, antibacterial and cytotoxic activity evaluation of hydroxyurea derivatives
Acta Pharmaceutica, 63 (2013), 2; 175-191. https://doi.org/10.2478/acph-2013-0014
Kos, Ivan; Jadrijević-Mladar Takač, Milena; Butula, Ivan; Biruš, Mladen; Maravić-Vlahoviček, Gordana; Dabelić, Sanja

Institucijski repozitorij: Repozitorij Farmaceutsko-biokemijskog fakulteta Sveučilišta u Zagrebu

Citirajte ovaj rad

Kos, I., Jadrijević Mladar Takač, M., Butula, I., Biruš, M., Maravić Vlahoviček, G. i Dabelić, S. (2013). Synthesis, antibacterial and cytotoxic activity evaluation of hydroxyurea derivatives. Acta Pharmaceutica, 63. (2), 175-191. doi: 10.2478/acph-2013-0014

Kos, Ivan, et al. "Synthesis, antibacterial and cytotoxic activity evaluation of hydroxyurea derivatives." Acta Pharmaceutica, vol. 63, br. 2, 2013, str. 175-191. https://doi.org/10.2478/acph-2013-0014

Kos, Ivan, Milena Jadrijević Mladar Takač, Ivan Butula, Mladen Biruš, Gordana Maravić Vlahoviček i Sanja Dabelić. "Synthesis, antibacterial and cytotoxic activity evaluation of hydroxyurea derivatives." Acta Pharmaceutica 63, br. 2 (2013): 175-191. https://doi.org/10.2478/acph-2013-0014

Kos, I., et al. (2013) 'Synthesis, antibacterial and cytotoxic activity evaluation of hydroxyurea derivatives', Acta Pharmaceutica, 63(2), str. 175-191. doi: 10.2478/acph-2013-0014

Kos I, Jadrijević Mladar Takač M, Butula I, Biruš M, Maravić Vlahoviček G, Dabelić S. Synthesis, antibacterial and cytotoxic activity evaluation of hydroxyurea derivatives. Acta Pharmaceutica [Internet]. 2013. [pristupljeno 28.12.2024.];63(2):175-191. doi: 10.2478/acph-2013-0014

I. Kos, M. Jadrijević Mladar Takač, I. Butula, M. Biruš, G. Maravić Vlahoviček i S. Dabelić, "Synthesis, antibacterial and cytotoxic activity evaluation of hydroxyurea derivatives", Acta Pharmaceutica, vol. 63, br. 2, str. 175-191, 2013. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:163:181762. [Citirano: 28.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:163:181762
Podaci o radu
Naslov (engleski)Synthesis, antibacterial and cytotoxic activity evaluation of hydroxyurea derivatives
AutorIvan Kos
AutorMilena Jadrijević-Mladar Takač
AutorIvan Butula
MBZ: 6372
AutorMladen Biruš
AutorGordana Maravić-Vlahoviček
AutorSanja Dabelić
Autorova ustanovaSveučilište u Zagrebu
Farmaceutsko-biokemijski fakultet
(Zavod za analitičku kemiju)
Autorova ustanovaSveučilište u Zagrebu
Farmaceutsko-biokemijski fakultet
(Zavod za farmaceutsku kemiju)
Autorova ustanovaSveučilište u Zagrebu
Farmaceutsko-biokemijski fakultet
(Zavod za opću i anorgansku kemiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Farmacija
Sažetak (engleski)
Synthesis and biological evaluation for a series (N = 16) of cyclic and acyclic hydroxyurea derivatives including benzotriazole-, isocyanuirc acid- and biuret-containing compounds, are disclosed. 1-N-(benzyloxycarbamoyl)benzotriazole was used as benzyloxyisocyanate donor, a useful intermediate in the preparation of substituted hydroxyurea. Antibacterial activities of synthesized hydroxyurea derivatives were tested on three E. coli strains, i.e., strain susceptible to antibiotics, strain resistant to macrolide antibiotics and strain resistant to aminoglycoside antibiotics. Six compounds (three acyclic and three cyclic hydroxyureas) showed the growth inhibition of tested E. coli strains, with different specificity toward each strain. Results of the cytotoxic activity evaluation revealed that twelve out of sixteen test compounds were cytotoxic to human acute monocytic leukemia THP-1 and/or on human acute T cell leukemia Jurkat cell line. 1-(N-hydroxycarbamoyl)benzotriazole (5) increased metabolic activity of both cell lines. Two compounds, 1-(N-hydroxycarbamoyl)benzotriazole (5) and N,N’,N’’-trihydroxybiuret (15) were identified as potential NO donors.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaActa Pharmaceutica
Brojčani podacivol. 63, br. 2, str. 175-191
p-ISSN1330-0075
e-ISSN1846-9558
DOIhttps://doi.org/10.2478/acph-2013-0014
URN:NBNurn:nbn:hr:163:181762
Datum objave publikacije2013
URL dokumentahttps://hrcak.srce.hr/97696
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2020-04-08 13:42:13