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Scientific paper - Original scientific paper
FT-IR i NMR spektroskopska istraživanja derivata salicilne kiseline. II. Usporedba 2-hidroksi- i 2,4- i 2,5-dihidroksi derivata
Acta Pharmaceutica, 54 (2004), 3; 177-191. urn:nbn:hr:163:078160
Jadrijević-Mladar Takač, Milena; Vikić Topić, Dražen

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Jadrijević Mladar Takač, M. & Vikić Topić, D. (2004). FT-IR i NMR spektroskopska istraživanja derivata salicilne kiseline. II. Usporedba 2-hidroksi- i 2,4- i 2,5-dihidroksi derivata. Acta Pharmaceutica, 54. (3), 177-191. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:078160

Jadrijević Mladar Takač, Milena and Dražen Vikić Topić. "FT-IR i NMR spektroskopska istraživanja derivata salicilne kiseline. II. Usporedba 2-hidroksi- i 2,4- i 2,5-dihidroksi derivata." Acta Pharmaceutica, vol. 54, no. 3, 2004, pp. 177-191. https://urn.nsk.hr/urn:nbn:hr:163:078160

Jadrijević Mladar Takač, Milena and Dražen Vikić Topić. "FT-IR i NMR spektroskopska istraživanja derivata salicilne kiseline. II. Usporedba 2-hidroksi- i 2,4- i 2,5-dihidroksi derivata." Acta Pharmaceutica 54, no. 3 (2004): 177-191. https://urn.nsk.hr/urn:nbn:hr:163:078160

Jadrijević Mladar Takač, M. and Vikić Topić, D. (2004) 'FT-IR i NMR spektroskopska istraživanja derivata salicilne kiseline. II. Usporedba 2-hidroksi- i 2,4- i 2,5-dihidroksi derivata', Acta Pharmaceutica, 54(3), pp. 177-191. Available at: https://urn.nsk.hr/urn:nbn:hr:163:078160 (Accessed 02 December 2024)

Jadrijević Mladar Takač M, Vikić Topić D. FT-IR i NMR spektroskopska istraživanja derivata salicilne kiseline. II. Usporedba 2-hidroksi- i 2,4- i 2,5-dihidroksi derivata. Acta Pharmaceutica [Internet]. 2004 [cited 2024 December 02];54(3):177-191. Available at: https://urn.nsk.hr/urn:nbn:hr:163:078160

M. Jadrijević Mladar Takač and D. Vikić Topić, "FT-IR i NMR spektroskopska istraživanja derivata salicilne kiseline. II. Usporedba 2-hidroksi- i 2,4- i 2,5-dihidroksi derivata", Acta Pharmaceutica, vol. 54, no. 3, pp. 177-191, 2004. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:163:078160. [Accessed: 02 December 2024]

Metadata
Title (croatian)FT-IR i NMR spektroskopska istraživanja derivata salicilne kiseline. II. Usporedba 2-hidroksi- i 2,4- i 2,5-dihidroksi derivata
Title (english)FT-IR and NMR spectroscopic studies of salicylic acid derivatives. II. Comparison of 2-hydroxy- and 2,4- and 2,5-dihydroxy derivatives
AuthorMilena Jadrijević-Mladar Takač
AuthorDražen Vikić Topić
Author's institutionUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of medicinal chemistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Medical Biochemistry
Abstract (croatian)
Spektroskopska svojstva derivata salicilne kiseline i 2,4- i 2,5-dihidroksi derivata benzojeve kiseline (metilnih estera i amida), 1 do 9, analizirana su pomoću FT-IR te jedno- i dvodimenzijske homo- i heteronuklearne 1H i 13C NMR spektroskopije. Dobiveni rezultati pokazuju da su FT-IR i NMR spektralne karakteristike derivata 2,4-dihidroksi-benzojeve kiseline (2,5,9) sličnije karakteristikama derivata salicilne kiseline (1,4,7) nego derivata 2,5-dihidroksi-benzojeve kiseline (3,6,9). Rezultati istraživaja ukazuju da je prostorna orijentacija amidnih protona 2,4-dihidroksibenzamida (8) sličnija orijentaciji amidnih protona salicilamida (7) nego 2,5-dihidroksibenzamida (9).
Abstract (english)
The 2,4- and 2,5-dihydroxybenzamides (8, 9) were synthesized from their corresponding methyl esters. The structures and the spectral properties of investigated salicylic acid (1), 2,4- and 2,5-dihydroxy benzoic acids (2, 3), their methyl esters (4-6) and amides (7-9) were analyzed by means of FT-IR and one- and two-dimensional homo- and heteronuclear 1H and 13C NMR spectroscopies. Comparison of FT-IR and NMR spectral data of investigated compounds showed that the spectral characteristics of 2,4-dihydroxy benzoic acid derivatives are more similar to those of 2-hydroxy benzoic acid (salicylic acid) derivatives than to those of 2,5-dihydroxy benzoic acid derivatives. The results suggest that the spatial orientation of amide protons in 2,4-dihydroxy benzamide resembles more that in salicylamide than that in 2,5-dihydroxy benzamide.
Keywords (croatian)
Keywords (english)
Languagecroatian
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleActa Pharmaceutica
Numberingvol. 54, no. 3, pp. 177-191
p-ISSN1330-0075
e-ISSN1846-9558
URN:NBNurn:nbn:hr:163:078160
Publication2004
Document URLhttps://hrcak.srce.hr/16862
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-04-09 14:04:35