prikaz prve stranice dokumenta Stability and structure of inclusion complexes of zaleplon with natural and modified cyclodextrins
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Scientific paper - Original scientific paper
Stability and structure of inclusion complexes of zaleplon with natural and modified cyclodextrins
Croatica Chemica Acta, 84 (2011), 2; 169-178. https://doi.org/10.5562/cca1800
Jug, Mario; Gabričević, Mario; Weitner, Tin; Jablan, Jasna

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Jug, M., Gabričević, M., Weitner, T. & Jablan, J. (2011). Stability and structure of inclusion complexes of zaleplon with natural and modified cyclodextrins. Croatica Chemica Acta, 84. (2), 169-178. doi: 10.5562/cca1800

Jug, Mario, et al. "Stability and structure of inclusion complexes of zaleplon with natural and modified cyclodextrins." Croatica Chemica Acta, vol. 84, no. 2, 2011, pp. 169-178. https://doi.org/10.5562/cca1800

Jug, Mario, Mario Gabričević, Tin Weitner and Jasna Jablan. "Stability and structure of inclusion complexes of zaleplon with natural and modified cyclodextrins." Croatica Chemica Acta 84, no. 2 (2011): 169-178. https://doi.org/10.5562/cca1800

Jug, M., et al. (2011) 'Stability and structure of inclusion complexes of zaleplon with natural and modified cyclodextrins', Croatica Chemica Acta, 84(2), pp. 169-178. doi: 10.5562/cca1800

Jug M, Gabričević M, Weitner T, Jablan J. Stability and structure of inclusion complexes of zaleplon with natural and modified cyclodextrins. Croatica Chemica Acta [Internet]. 2011 [cited 2024 December 21];84(2):169-178. doi: 10.5562/cca1800

M. Jug, M. Gabričević, T. Weitner and J. Jablan, "Stability and structure of inclusion complexes of zaleplon with natural and modified cyclodextrins", Croatica Chemica Acta, vol. 84, no. 2, pp. 169-178, 2011. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:163:767001. [Accessed: 21 December 2024]

Metadata
Title (english)Stability and structure of inclusion complexes of zaleplon with natural and modified cyclodextrins
AuthorMario Jug
AuthorMario Gabričević
AuthorTin Weitner
AuthorJasna Jablan
Author's institutionUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of pharmaceutical technology)
Author's institutionUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of general and inorganic chemistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract (english)
The interaction between zaleplon (ZAL) and different cyclodextrins in aqueous solutions was investigated by spectrofluorimetric and phase solubility studies. Stability constants determined by both methods showed that among natural cyclodextrins, β-cyclodextrin (βCD) formed the most stabile complex but its solubilizing efficiency was limited. Among βCD derivatives, the complex stability and solubilisation efficiency decreased in order: randomly methylated-βCD (RAMEB) > sulphobutylether-βCD (SBEβCD ) > hydroxypropyl-βCD (HPβCD). The inclusion complexes of ZAL with βCD and RAMEB were further characterised by 1H-NMR spectroscopy and the inclusion complex formation was confirmed in both cases. ROESY spectra showed two binding modes between ZAL and βCD which exist simultaneously in the solution. The first binding mode occurs by the inclusion of the phenyl ring of ZAL into the βCD central cavity via the wider rim of the cyclodextrin cone and is dominant. The second one is formed by the inclusion of pyrazolo[1,5-a]pyrimidine ring of ZAL.(doi: 10.5562/cca1800)
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleCroatica Chemica Acta
Numberingvol. 84, no. 2, pp. 169-178
p-ISSN0011-1643
e-ISSN1334-417X
DOIhttps://doi.org/10.5562/cca1800
URN:NBNurn:nbn:hr:163:767001
Publication2011
Document URLhttps://hrcak.srce.hr/71979
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-04-17 16:36:04