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master's thesis
Dizajn i sinteza novih malih molekula kao inhibitora Chikungunya virusa
Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2018. urn:nbn:hr:163:459130
Pejaković, Tajana Iva
University of Zagreb
Faculty of Pharmacy and Biochemistry
Department of medicinal chemistry

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

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Pejaković, T. I. (2018). Dizajn i sinteza novih malih molekula kao inhibitora Chikungunya virusa (Master's thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:459130

Pejaković, Tajana Iva. "Dizajn i sinteza novih malih molekula kao inhibitora Chikungunya virusa." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2018. https://urn.nsk.hr/urn:nbn:hr:163:459130

Pejaković, Tajana Iva. "Dizajn i sinteza novih malih molekula kao inhibitora Chikungunya virusa." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2018. https://urn.nsk.hr/urn:nbn:hr:163:459130

Pejaković, T. I. (2018). 'Dizajn i sinteza novih malih molekula kao inhibitora Chikungunya virusa', Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 29 December 2024, https://urn.nsk.hr/urn:nbn:hr:163:459130

Pejaković TI. Dizajn i sinteza novih malih molekula kao inhibitora Chikungunya virusa [Master's thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2018 [cited 2024 December 29] Available at: https://urn.nsk.hr/urn:nbn:hr:163:459130

T. I. Pejaković, "Dizajn i sinteza novih malih molekula kao inhibitora Chikungunya virusa", Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:163:459130

Metadata
TitleDizajn i sinteza novih malih molekula kao inhibitora Chikungunya virusa
Title (english)Design and synthesis of new small molecules as Chikungunya virus inhibitors
AuthorTajana Iva Pejaković
MentorMirza Bojić (mentor)
Committee memberMirza Bojić (predsjednik povjerenstva)
Committee memberŽeljan Maleš (član povjerenstva)
Committee memberMirela Matić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of medicinal chemistry)
Zagreb
Defense date and country2018-07-12, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract
The worldwide impact of Chikungunya virus (CHIKV) and the emergence of new transmission strains in Europe and Americas shows that arthritogenic Alphaviruses infections pose a serious public health issue. There are no vaccines or antivirals available for the prevention or treatment of CHIKV infection, and most of the treatment regimens are symptomatic and based on the clinical manifestations. The purpose of this thesis was to synthesize new carbonyl compounds that could act as CHIKV inhibitors. Compound 4 was prepared by nitration with concentrated sulfuric acid using the commercially available 4'-chloroacetophenone. Compound 3 was prepared using Suzuki-Miyaura cross coupling reaction, while compound 2 was prepared using PPh3-mediated reductive cyclization. Both of the compounds 1a and 1b were prepared with base catalyzed aldol reaction, using the previously synthesized compound 2 and commercially available benzaldehyde and 3-bromo-4-methoxybenzaldehyde. The structures of the compounds were confirmed by usual analytical and spectroscopic methods (IR and 1H NMR spectroscopy).
Abstract (croatian)
Utjecaj Chikungunya virusa (CHIKV) širom svijeta te pojavljivanje novih prijenosnih sojeva u Europi i Americi pokazuje koliko ozbiljni javnozdravstveni problem predstavljaju infekcije artritogenim Alphavirus-ima. Ne postoji cjepivo niti antivirotik na tržištu koji bi se koristio u prevenciji ili liječenju CHIKV infekcije, a većina terapije je simptomatska i temelji se na kliničkim manifestacijama. Cilj ovog rada je bio sintetizirati nove derivate karbonila koji bi mogli djelovati kao CHIKV inhibitori. Spoj 4 je pripremljen nitracijom komercijalno dostupnog 4'-kloracetofenona koristeći koncentriranu sumpornu kiselinu. Spoj 3 pripremljen je Suzuki-Miyaura reakcijskim mehanizmom, dok je spoj 2 pripremljen uz PPh3-potpomognutu reduktivnu ciklizaciju. Spojevi 1a i 1b su sintetizirani bazičnom aldolnom kondenzacijom, koristeći prethodno pripremljeni spoj 2 i komercijalno dostupni benzaldehid i 3-bromo-4-metoksibenzaldehid. Strukture svih sintetiziranih spojeva potvrđene su uobičajenim spektroskopskim metodama (IR, 1H NMR).
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:163:459130
Study programmeTitle: Pharmacy
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2021-04-22 11:43:58